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Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy

Billions of animals are adapted to a travelling life, making regular return migrations between more or less distant living stations on Earth by swimming, flying, running or walking (Figure 1). Extremely long migrations are completed annually by whales between calving areas in warmer waters and feeding areas at higher latitudes in either hemisphere. The longest oceanic migrations among sea turtles

The resilience of nationalism in contemporary Europe may seem paradoxical at a time when the nation state is widely seen as being 'in decline'. The contributors of this book see the resurgence of nationalism as symptomatic of the quest for identity and meaning in the complex modern world. Challenged from above by the supranational imperatives of globalism and from below by the complex pluralism of

One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. An increasing number of cities have become significant tourism destinations. Cities also attract an increasingly diverse set of visitors, some of which could be called alternative tourists. The development of alternative tourism is related to decreasing relative costs One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. An increasing number of cities have become significant tourism destinations. Cities also attract an increasingly diverse set of visitors, some of which could be called alternative tourists. The development of alternative tourism is related to decreasing relative costs

Continuously monitoring its position in space relative to a goal is one of the most essential tasks for an animal that moves through its environment. Species as diverse as rats, bees, and crabs achieve this by integrating all changes of direction with the distance covered during their foraging trips, a process called path integration. They generate an estimate of their current position relative to

What do a burly rower, a backstroke swimmer and a hard-working South African dung beetle all have in common? The answer is: they all benefit from moving along a straight path, and do so moving backwards. This, however, is where the similarity ends. While the rower has solved this navigational challenge by handing the task of steering to the coxswain, who faces the direction of travel, and the swim

A new method to improve the accuracy and efficiency of characteristic mode (CM) decomposition for perfectly conducting bodies is presented. The method uses the expansion of the Green dyadic in spherical vector waves. This expansion is utilized in the method of moments (MoM) solution of the electric field integral equation (EFIE) to factorize the real part of the impedance matrix. The factorization

This article accounts for and problematizes the process and development with the research tool and method, “the Life-Line”, which we used in our project Gaming Moms. Juggling Time, Play and Everyday Life (Enevold & Hagström 2008a) to involve our informants in the production, outcome and consumption of research beyond merely being respondents to interview-questions. We propose to call the colla

Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all patients aged above 18 years who were diagnosed with gambling disorder (correspon

With growing urbanisation the sustainability of cities has become increasingly important. Although cities have been using indicators for a long time it is only in the last decades that attempts have been made to collate indicators into sets that reflect the many different aspects required to assess the sustainability of a city. The aim of this paper is to review the evolution of indicators for mon

This paper contributes to literature on bank distress using the Swedish experience of the in- ternational crisis of 1907, often paralleled with 2008. By employing previously unanalyzed bank-level data, we use logit regressions and principal component analysis to measure the im- pact of pre-crisis bank characteristics on the probability of their subsequent distress. The crisis was characterized by

Wage restraint plays an important role in the conventional economic history explanation of the post-war golden growth experience of industrialized economies. Conversely, wage increases harming investment and increasing unemployment have been proffered as explanations for some of the high unemployment during the interwar period. This article argues that the conventional account implicitly only cons