Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of aggregation involves primary and secondary nucleation steps. We show how a noncanonical member of the DNAJ-chaperone family, DNAJB6, inhibits the conversion of soluble polyQ peptides into amyloid fibrils, in particular by suppre

Arrangements to cooperate on innovation facilitate access to external sources of knowledge. By using panel data derived from the five waves of Community Innovation Survey in the Czech Republic, we examine whether firms engage in these arrangements persistently or rather revert to other behaviour. Econometric estimates of dynamic random effects and multivariate probit models provide strong support

Much has been written about innovation cooperation, but little research has been done to explain the national differences thereof. Using macro and micro evidence from the fourth Community Innovation Survey, we econometrically investigate the extent to which national framework conditions account for the propensity of firms to cooperate on innovation at home and abroad. The results indicate strong d

The recent economic crisis caught many by surprise. Yet some firms were better prepared to weather the downturn than others. Using a unique micro dataset of shareholding companies from emerging countries in Eastern and Southern Europe derived from the World Bank's Enterprise Surveys, we econometrically test the hypothesis that pre-crisis innovation affected their survival odds and performance ther

Using panel micro data fro\m Community Innovation Survey in the Czech Republic, Norway and the UK, we estimate dynamic random effects models, in which the innovation output of firms is the function of their cooperative behaviour and other observed characteristics, while accounting for unobserved heterogeneity. The results indicate that the capacity of firms to build on external domestic linkages i

Innovation is often seen as carried out by highly educated labor in R&D intensive companies with strong ties to leading centers of excellence in the scientific world. Seen from this angle innovation is a typical "first world" activity. There is, however, another way to look at innovation that goes significantly beyond this high-tech picture. In this broader perspective, innovation-the attempt

SRHOLEC M. A multilevel approach to geography of innovation, Regional Studies. The aim of this paper is to demonstrate how research on geography of innovation can benefit from multilevel modelling. Using micro-data from the third Community Innovation Survey in the Czech Republic, the hypothesis that regional framework conditions determine the innovative performance of firms and that this effect di

The paper presents alternative analytical approaches to evaluation of structural changes in selected transition economies (Czech Republic, Poland, Hungary, Slovakia, Slovenia). The analysis starts from the comparison of intensity of structural changes, as an introductory (quantitative) concept measuring structural adjustment capacity. Besides the intensity of structural changes, the need for devel

Wikipedia has become one of the most popular resources in natural language processing and it is used in quantities of applications. However, Wikipedia requires a substantial pre-processing step before it can be used. For instance, its set of nonstandardized annotations, referred to as the wiki markup, is language-dependent and needs specific parsers from language to language, for English, French,

BACKGROUND AND AIM: Many multilevel logistic regression analyses of "neighbourhood and health" focus on interpreting measures of associations (e.g., odds ratio, OR). In contrast, multilevel analysis of variance is rarely considered. We propose an original stepwise analytical approach that distinguishes between "specific" (measures of association) and "general" (measures of variance) contextual eff