Search results

Filter

Filetype

Your search for "*" yielded 528606 hits

Overweight and vitamin D deficiency are common in patients with irritable bowel syndrome - a cross-sectional study

Background: Irritable bowel syndrome (IBS) is a common disease with unknown etiology. Poor dietary intake with nutritional deficiency and overweight have been described to increase the risk of IBS. The aim of the present study was to compare weight and circulating levels of micronutrients in IBS compared with healthy controls. Design: Cross-sectional study. Methods: Patients diagnosed with IBS and

Bi-allelic NRXN1α deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on neuronal networking

Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental conditions, with a highly diverse genetic hereditary component, including altered neuronal circuits, that has an impact on communication skills and behaviours of the affected individuals. Beside the recognised role of neuronal alterations, perturbations of microglia and the associated neuroinflammatory processes have emerg

Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes : Rationale and design of a two-armed double blind randomized controlled trial

Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot x

Will the EU deforestation-free products regulation (EUDR) reduce tropical forest loss? Insights from three producer countries

The European Union regulation on deforestation-free products (EUDR) represents a policy innovation with important implications for the governance of global commodity chains. We discuss the risks and limitations of this policy derived from an ex-ante assessment of the robustness of its theory of change. For doing so, we use insights from the literature on zero-deforestation commitments and other pr

Monoclinic distortion and magnetic transitions in FeO under pressure and temperature

Fe1-xO, although chemically simple, possesses a complex structural and magnetic phase diagram. The crystal structures of Fe1-xO and its magnetic properties at extreme conditions are still a matter of debate. Here, we performed a systematic investigation on Fe0.94O up to 94 GPa and 1700 K using synchrotron X-ray diffraction and synchrotron Mössbauer source spectroscopy. We observe a transition of F

Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration

The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data. Here, we summarize the existing GEMRIC cognitive data and provide recommendati

Thermodynamic and kinetic study of palladium(II) complexation with 1-methyl-2-mercaptoimidazole (methimazole) and their importance for structural design of metallodrugs

The acidobasic and complexing properties of 1-methyl-2-mercaptoimidazole (Methimazole, an anti-thyroid drug) were investigated. The pKa 11.49 ± 0.03 was estimated by molecular absorption spectroscopy (I = 0.10 M NaCl, t = 25.0 ± 0.1 °C). This value is in good agreement with the value 11.58 ± 0.05, obtained using the solvent-extraction technique. Theoretical (LFER and quantum chemical calculations)

Analytical study of a generalised Dirichlet–Neumann operator and application to three-dimensional water waves on Beltrami flows

We consider three-dimensional doubly periodic steady water waves with vorticity, under the action of gravity and surface tension; in particular we consider so-called Beltrami flows, for which the velocity field and the vorticity are collinear. We adapt a recent formulation of the corresponding problem for localised waves which involves a generalisation of the classical Dirichlet–Neumann operator.

Genomic variation in Plasmodium relictum (lineage SGS1) and its implications for avian malaria infection outcomes : insights from experimental infections and genome-wide analysis

Background: The globally transmitted avian malaria parasite Plasmodium relictum (lineage SGS1) has been found to infect hundreds of different bird species with differences in infection outcomes ranging from more or less latent to potentially mortal. However, to date basic knowledge about the links between genetic differentiation and variation in infection outcome within this single malaria parasit

Impact of the energy crisis on indoor temperatures and thermal comfort in UK houses during winter 2023

Geopolitical, health and economic events have led to an accumulated surge in energy prices in the UK at the beginning of the 2020s. In response, studies and media reports show that households have had to reduce the running of their heating systems to cut their energy bills. However, there is limited research on the impact of this context on indoor thermal conditions and occupants’ ability to meet

Accurate quantification of soil organic matter content using VNIR-SWIR spectra : The role of straw and spectrally active materials

Soil organic matter (SOM) is crucial for carbon sequestration and sustainable agriculture, yet traditional quantification methods are challenging to apply at large scales. Hyperspectral technology combined with machine-learning offers promising prospects for rapid quantification. This study explores the impact of using VNIR-SWIR spectra on SOM quantification in regions characterized by distinctive

Perioperative blood transfusions associated with reduced survival in gastroesophageal cancers – A Swedish population-based study

Background: Blood transfusion has been associated with decreased long-term survival in cancer patients, possibly due to various immunological factors. We aimed to evaluate if perioperative transfusions decrease survival in patients who undergo resection for esophageal or gastric cancer and to identify factors associated with such events. Methods: A population-based cohort study was conducted based

Total mercury and methylmercury in lake water in years before and after removal of mercury-polluted pulp fiber sediment

There is an elevated presence of mercury (Hg) in the biosphere because of anthropogenic activities. The resulting damage to ecosystems and human health increases dramatically when microorganisms produce highly toxic methylmercury (MeHg). Total Hg (THg), MeHg and ancillary water chemistry were measured in two connected lakes, separated by a short stream stretch, before (1996, 1998 and 2003) and aft

The association between hip adductor and extensor strength, and hip-related patient-reported outcomes in patients with longstanding hip and groin pain : An exploratory cross-sectional study

Objective: The objective of this study was to assess the association between hip muscle strength and hip-related patient-reported outcome measures (PROMs) in patients with longstanding hip and groin pain (LHGP). Design: Cross-sectional design. Setting: Orthopedic care. Participants: Eighty-one patients with LHGP were consecutively recruited. Main outcome measures: Hip muscle strength was measured

Relative K-homology of higher-order differential operators

We extend the notion of a spectral triple to that of a higher-order relative spectral triple, which accommodates several types of hypoelliptic differential operators on manifolds with boundary. The bounded transform of a higher-order relative spectral triple gives rise to a relative K-homology cycle. In the case of an elliptic differential operator on a compact smooth manifold with boundary, we ca

A “poor-man's” deformation plasticity based approach to topology optimization of elastoplastic structures

This paper presents a topology optimization framework utilizing a deformation plasticity model to approximate the isotropic hardening von-Mises incremental elastoplasticity model under monotone proportional loading. One advantage of the model is that it is based on a yield surface allowing for precise matching to uniaxial elastoplastic isotropic hardening response. The deformation plasticity model

“The Song of the Shirt” Replanted : Thomas Hood’s Poem in a Nordic Context

Thomas Hood’s poem “The Song of the Shirt” was an immediate success when first published in Punch in 1843. Previous research has shown how the poem responded to the mid-nineteenth-century debate concerning the working situation of needlewomen. The ways in which this hugely popular poem was recontextualised in translation have, however, received surprisingly little attention. Arguing that British nThomas Hood’s poem “The Song of the Shirt” was an immediate success when first published in Punch in 1843. Previous research has shown how the poem responded to the mid-nineteenth-century debate concerning the working situation of needlewomen. The ways in which this hugely popular poem was recontextualised in translation have, however, received surprisingly little attention. Arguing that British n

Balancing risk and reward : exploring women’s transactional sexual relationships with Blessers in South Africa

Transactional sexual relationships (TSRs) take varied forms, with research emphasizing TSRs’ inherent risks, primarily to women. In South Africa, Blessed relationships have emerged as a prominent type of TSR. Blessers have become coveted male partners due to their relative wealth and willingness to ‘bless’ female partners with financial and material gifts, as well as the improved social status tha

Wolbachia strain diversity in a complex group of sympatric cryptic parasitoid wasp species

Background: Maternally-inherited symbionts can induce pre-mating and/or post-mating reproductive isolation between sympatric host lineages, and speciation, by modifying host reproductive phenotypes. The large parasitoid wasp genus Cotesia (Braconidae) includes a diversity of cryptic species, each specialized in parasitizing one to few related Lepidoptera host species. Here, we characterized the in