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Bland Kurtar och Skymtar : Fundament och subjekt två svenska berättelser
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Bridge management systems : A review on current practice in a digitizing world
Bridges are subject to a plethora of deterioration phenomena, such as corrosion, fatigue, and damaging events (e.g., truck impacts and earthquakes) that can affect their performance and compromise functionality and safety. These challenges, along with the expansion of physical infrastructures and limited economic resources, underscore the need for effective management systems to enhance the effici
Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease
Identifying concomitant Lewy body (LB) pathology through seed amplification assays (SAA) might enhance the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice and trials. This study examined whether LB pathology exacerbates AD-related disease progression in 795 cognitively impaired individuals (Mild Cognitive Impairment and dementia) from the longitudinal multi-cente
Resting-state EEG correlates of sustained attention in healthy ageing : Cross-sectional findings from the LEISURE study
While structural and biochemical brain changes are well-documented in ageing, functional neuronal network differences, as indicated by electrophysiological markers, are less clear. Moreover, age-related changes in sustained attention and their associated electrophysiological correlates are still poorly understood. To address this, we analysed cross-sectional baseline electroencephalography (EEG) a
Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study
Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention perfor
Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study
On the gendering of the early American electric car
The role of gender relations in shaping technological transitions is widely acknowledged but remains understudied. This study uses historical data to analyze the gendering of early 20th century American cars and its impact. Previous research has argued that early electric vehicles were construed as a women's car, contributing to its demise. Other work has questioned to what extent automotive prefe
The contractual protection of authors in Copyright in the Digital Single Market Directive – does the reality live up to the expectations?
Microbial resistance and resilience to drought across a European climate gradient
Drought and rainfall events will become more frequent and intense with climate change. At the same time, soil moisture is one of the major factors controlling soil microbial processes such as carbon cycling. When challenged with drought there are two main growth responses microorganisms can use: (1) they can maintain growth rates during drought (i.e., resistance) and (2) they can recover growth ra
Transcriptome analysis of the aortic coarctation area
Background: Coarctation of the aorta (CoA) is a relatively common congenital heart defect. The underlying causes are not known, but a combination of genetic factors and abnormalities linked to embryonic development is suspected. There are only a few studies of the underlying molecular mechanisms in CoA. The aim of the current study was to expand our understanding of the pathogenesis of CoA by char
Photoinduced charge transfer assisted through external electric field and ternary hydrogen bonding strategies
Understanding the mechanisms governing interfacial charge transfer in photoactive layer is crucial for optimizing photogenerated charge separation efficiency. In this study, the interfacial charge transfer process is regulated by applying external electric field (Fext) and ternary hydrogen bonding strategies. We observe significant changes in the excited state properties and charge transfer parame
Should end-users take their clothes off inside on a cold winter's day? Sustainability pressures on district heating professionals in Denmark
This research explores how district heating (DH) sector professionals /employees experience the low-carbon energy transitions-related change processes in the Danish heat supply sector. Enquiry draws upon mixed data collected among DH employees from 148 utilities. Geels’ triple embeddedness framework conceptualizes the connections between regime-level actor experiences of niche- and landscape-level
Sequence variants influencing the regulation of serum IgG subclass levels
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci
Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
Schisandrin B (Sch B) is a predominant bioactive lignan from the fruit of a Chinese medicine food homology plant, Schisandra chinensis. Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) and enhanced chemotherapy efficacy with fluorouracil (5-FU). However, their bioavailability and reciprocal interactions under CRC conditions are unclear. In this study, we first c
Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions
Hematopoietic stem cells (HSCs) react to various stress conditions. However, it is unclear whether and how HSCs respond to severe anemia. Here, we demonstrate that upon induction of acute anemia, HSCs rapidly proliferate and enhance their erythroid differentiation potential. In severe anemia, lipoprotein profiles largely change and the concentration of ApoE increases. In HSCs, transcription levels
A Resonant Lyapunov Centre Theorem with an Application to Doubly Periodic Travelling Hydroelastic Waves
We present a Lyapunov centre theorem for an antisymplectically reversible Hamiltonian system exhibiting a nondegenerate 1 : 1 or 1:-1 semisimple resonance as a detuning parameter is varied. The system can be finite- or infinite-dimensional (and quasilinear) and have a non-constant symplectic structure. We allow the origin to be a ‘trivial’ eigenvalue arising from a translational symmetry or, in an
Cost-effectiveness of proton beam therapy vs. conventional radiotherapy for patients with brain tumors in Sweden : results from a non-randomized prospective multicenter study
Background: This study assessed the cost-effectiveness of proton beam therapy (PBT) compared to conventional radiotherapy (CRT) for treating patients with brain tumors in Sweden. Methods: Data from a longitudinal non-randomized study performed between 2015 and 2020 was used, and included adult patients with brain tumors, followed during treatment and through a one-year follow-up. Clinical and demo