In this work, asymmetrical flow field-flow fractionation (AF4) coupled with UV/Vis, multi-angle light scattering (MALS), and differential refractive index (dRI) detectors (AF4-UV-MALS-dRI) was employed for analysis of glutamate decarboxylase (LbGadB) from Lactobacillus brevis (L. brevis). AF4 provided molecular weight (MW) (or size)-based separation of dimer, hexamer, and aggregates of LbGadB. The

OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-di

Objective: To determine recent trends in the rate and management of new cases of OA presenting to primary healthcare using UK nationally representative data.Methods: Using the Clinical Practice Research Datalink we identified new cases of diagnosed OA and clinical OA (including OA-relevant peripheral joint pain in those aged over 45 years) using established code lists. For both definitions we esti

About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. The aim of this thesis was to evaluate new potential prognostic biomarkers in breast cancer, and with special focu

Considerable progress in the investigation of the electronic and vibrational properties of atoms, molecules, materials, surfaces and interfaces has been achieved by combining different photon sources of complementary characteristics. In this paper some experimental results obtained recently at LURE by using two synchronized sources, such as the IR free-electron laser (FEL) CLIO, the VUV storage ri

Graphical user interface (GUI) development is generally complicated, time-consuming, and requires programming knowledge. In the context of the internet of things, this work focuses on producing an efficient development approach that also supports non-experts. We introduce a novel "inverted" development approach that does not require program code to be written - a step towards supporting end-user d

Background Previous trials of interferon in multiple sclerosis (MS) have shown efficacy, but the degree of clinical benefit remains uncertain, and the optimum dose is not known. We undertook a double-blind, placebo-controlled study in relapsing/remitting MS to investigate the effects of subcutaneous interferon -1a. Methods 560 patients with Kurtzke expanded disability status scale (EDSS) scores of

Aluminium-based adjuvants (ABAs) have been used in human and veterinary vaccines for decades, and for a long time, the adjuvant properties were believed to be mediated by an antigen depot at the injection site, prolonging antigen exposure to the immune system. The depot hypothesis is today more or less abandoned, and instead replaced by the assumption that ABAs induce an inflammation at the inject

Do you know silica, the tetrahedra of silicon and oxygen constituting the crystals of New Agers and the desiccant in a box of new shoes? It’s no mere mundane mineral. As chemically reacting silicate rocks, silica set off the chain of events known as the origin of life. As biomineralized opal, it is the cell wall, skeleton, spicules, and scales of organisms ornamenting numerous lobes of the tree of

Antenna current optimization is often used to analyze the optimal performance of antennas. Antenna performance can be quantified in <i>e.g.</i>, minimum Q-factor and radiation efficiency. The performance of MIMO antennas is more involved and, in general, a single parameter is not sufficient to quantify it. Here, the capacity of an idealized channel is used as th

Laser based spectroscopic techniques can be used in the detection and therapy of many human diseases. Examples will be given from a variety of clinical areas, such as oncology, orthopedics and pediatrics, and also from the field of food safety and antibiotic control.

Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine. However, generation of desired cell types using this approach is often plagued by inefficiency, slow conversion, and an inability to produce mature functional cells. Here, we show that expression of constit

Meteorites have captured our fascination since our early history-they have evoked awe, fear, an irresistible curiosity, and numerous lively debates. Former historians have indicated that many of the ancient cultures and civilizations in Europe, Africa, Asia, the Inuit, and the native Indians in America regarded both the meteorite and the location of their fall as sacred. Thus, they used the meteor

Pathologic complete response (pCR) is a predictor for favorable outcome after neoadjuvant treatment in early breast cancer. Modulation of gene expression may also provide early readouts of biological activity and prognosis, offering the possibility for timely response-guided treatment adjustment. The role of early transcriptional changes in predicting response to neoadjuvant chemotherapy plus beva

This paper concerns the VSC-HVDC application to improve the long-term voltage stability. For this purpose the NORDIC32 test system is considered. All necessary dynamics to study the long-term voltage stability are included in the test system. An appropriate control strategy for VSC-HVDC is proposed in the paper. The goal is to reach the best condition from long-term voltage stability perspective w