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Laser spectroscopy to meet some challenges in medicine

Laser based spectroscopic techniques can be used in the detection and therapy of many human diseases. Examples will be given from a variety of clinical areas, such as oncology, orthopedics and pediatrics, and also from the field of food safety and antibiotic control.

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming

Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine. However, generation of desired cell types using this approach is often plagued by inefficiency, slow conversion, and an inability to produce mature functional cells. Here, we show that expression of constit

The extreme biology of meteorites : Their role in understanding the origin and distribution of life on earth and in the universe

Meteorites have captured our fascination since our early history-they have evoked awe, fear, an irresistible curiosity, and numerous lively debates. Former historians have indicated that many of the ancient cultures and civilizations in Europe, Africa, Asia, the Inuit, and the native Indians in America regarded both the meteorite and the location of their fall as sacred. Thus, they used the meteor

Assessment of early response biomarkers in relation to long-term survival in patients with HER2-negative breast cancer receiving neoadjuvant chemotherapy plus bevacizumab : Results from the Phase II PROMIX trial

Pathologic complete response (pCR) is a predictor for favorable outcome after neoadjuvant treatment in early breast cancer. Modulation of gene expression may also provide early readouts of biological activity and prognosis, offering the possibility for timely response-guided treatment adjustment. The role of early transcriptional changes in predicting response to neoadjuvant chemotherapy plus beva

VSC-HVDC application to improve the long-term voltage stability

This paper concerns the VSC-HVDC application to improve the long-term voltage stability. For this purpose the NORDIC32 test system is considered. All necessary dynamics to study the long-term voltage stability are included in the test system. An appropriate control strategy for VSC-HVDC is proposed in the paper. The goal is to reach the best condition from long-term voltage stability perspective w

Shaken baby syndrome and the risk of losing scientific scrutiny

A systematic review of shaken baby syndrome by the Swedish Agency for Health Technology Assessment and Assessment of Social Services generated numerous reactions from professional organisations, even before the review was published. There was also a lively debate after a paper summarising its findings were published in Acta Paediatrica The various responses are worth debating further, as they rais

Unexpected Sensitivity of Nitrogen Ions Superradiant Emission on Pump Laser Wavelength and Duration

Nitrogen molecules in ambient air exposed to an intense near-infrared femtosecond laser pulse give rise to cavity-free superradiant emission at 391.4 and 427.8 nm. An unexpected pulse duration-dependent cyclic variation of the superradiance intensity is observed when the central wavelength of the femtosecond pump laser pulse is finely tuned between 780 and 820 nm, and no signal occurs at the reson

A novel method to increase the accuracy of material characterization using free space transmission measurements

This paper describes a method to accurately determine the electromagnetic material properties of thin dielectric sheets. For non-magnetic materials, free space transmission measurements relative to an empty setup are sufficient to determine the complex permittivity of the sheet material. Measurements have been performed on a thin resistive sheet and a transformation procedure has been applied wher

Development and application of high-speed laser visualization techniques in combustion research

In order to fulfil the requirements of available energy resources, there is a great need to obtain a sustainable and environmentally friendly energy utilization using combustion processes. In order to do this, it is of utmost importance to utilize non-intrusive diagnostic techniques with high spatial and temporal resolution which can characterize the combustion process and also validate combustion

Health behavior in the Nordic countries

This paper provides a descriptive analysis of the level of and change in cigarette smoking, excessive alcohol consumption and body weight in Nordic countries and compares them with non-Nordic OECD countries. Our results show that the average prevalence of daily smokers is significantly lower for Nordic countries compared to non-Nordic countries. Four out of five Nordic countries are below the non-

Do kidney transplantations save money? – A study using a before–after design and multiple register-based data from Sweden

Background: The health care costs of kidney transplantation and dialysis are generally unknown. This study estimates the Swedish health care costs of kidney transplantation and dialysis over 10 years from a health care perspective.Method: A before–after design was used, in which the patients served as their own controls. Health care costs the year before transplantation were assumed to continue in

Combined Low and High Pressure EGR for Higher Brake Efficiency with Partially Premixed Combustion

The concept of Partially Premixed Combustion (PPC) in internal combustion engines has shown to yield high gross indicated efficiencies, but at the expense of gas exchange efficiencies. Most of the experimental research on partially premixed combustion has been conducted on compression ignition engines designed to operate on diesel fuel and relatively high exhaust temperatures. The partially premix

Comparison of Gasoline and Primary Reference Fuel in the Transition from HCCI to PPC

Our previous research investigated the sensitivity of combustion phasing to intake temperature and injection timing during the transition from homogeneous charge compression ignition (HCCI) to partially premixed combustion (PPC) fuelled with generic gasoline. The results directed particular attention to the relationship between intake temperature and combustion phasing which reflected the changing

Local and trans-Atlantic chemostratigraphic significance of new δ13Ccarb data from the Sandbian and Katian Stages (Middle–Upper Ordovician) of the Oslo region, Norway

Late Sandbian to early Katian δ13Ccarb chemostratigraphy has in Norway been described in only two previous reports that dealt with two geographically rather widely separated areas, namely the Oslo-Asker district and the Nes-Hamar district. No data have been available from the Ordovician outcrop areas between these districts that could help clarify the partly unclear regional stratigraphic relation

Reduced kidney function is associated with BMD, bone loss and markers of mineral homeostasis in older women : a 10-year longitudinal study

Summary: Kidney function decreases with age; however, the long-term influence on bone density (BMD) in older women already at risk of osteoporosis is unknown. We followed kidney function and bone loss for 10 years. Declining kidney function was adversely associated with bone loss and mineral homeostasis in old women, though it attenuated with advanced aging. Introduction: Existing studies do not f