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All patients in a randomized study comparing chemotherapy with chemotherapy plus radiotherapy for patients with astrocytomas grade 3 and 4, were considered for reoperation when tumour progression was established. Fifty-eight patients were reoperated and 85 were not. Different prognostic factors, such as age, sex, Karnofsky performance status and reoperation were evaluated univariately and simultan
An important part of an electrocardiogram (ECG) interpretation is the comparison between the present ECG and earlier recordings. The purpose of the present study was to evaluate a combination of two computer-based methods, synthesized vectorcardiogram (VCG) and CAVIAR, in this comparison. The methods were applied to a group of 38 normal subjects and to a group of 36 patients treated with anthracyc
In this paper we seek to reflect on the way in which 'digital cities' later re-emerge as 'smart cities' (both in terms of the approaches and also the actual cities) and what lessons can be learned about the role of ICTs in how they shape urban space. We will focus on looking at how the lack of understanding of the city as a 'place' is often a common factor in the lack of longevity in 'digital city
Floral scent is an important mediator of plant–pollinator interactions. Multiple recent studies report ample intraspecific scent variation among populations and individuals. Yet, few studies have eastimated effects of phenotypic plasticity on floral scent in response to differing environmental factors. In this study, we investigated the effects of nutrient and water availability on floral scent in
For Kristeva (1982) the abject not only caused visceral disgust but posed a threat to the established order of society. The abject is a product of particular times and places but limited attention has been given to understanding the process of transitioning away from abject status. We address this gap here through an examination of the planning profession in post-apartheid South Africa. The paper
Evolutionary ecology aims to better understand how ecologically important traits respond to environmental heterogeneity. Environments vary both naturally and as a result of human activities, and investigations that simultaneously consider how natural and human-induced environmental variation affect diverse trait types grow increasingly important as human activities drive species endangerment. Here
Pollinators experience large spatiotemporal fluctuations in resource availability when mass-flowering crops are rotated with resource-poor cereal crops. Yet, few studies have considered the effect this has on pollinator population stability, nor how this might be mitigated to maintain consistent crop pollination services. We assess the potential of boundary features (standard narrow 1 m grassy mar
Background and Aims: Alcohol use disorder (AUD) is associated with increased risk of non-fatal suicide attempt. We aimed to measure the strength and mechanistic nature of the association between AUD and increased suicide attempt and determine any causal pathways and/or shared risk factors. Design: We used Cox proportional hazards models in population-level and co-relative analyses to evaluate the
Sixty-nine patients with locally advanced breast cancer were given induction chemotherapy with doxorubicin and cyclophosphamide (day 1) followed by methotrexate and 5-Fu (day 8). Thirty-two of these patients were also given tamoxifen (days 2-6) in an attempt to induce a G1 arrest in cancer cells, and oestrogen (days 7-8) to stimulate proliferation and thus induce a synchronized wave of proliferati
Objectives: To estimate resource use and costs, including direct and indirect costs, in relation to levels of severity in individuals with Parkinson's disease (PD) in a Swedish setting. Materials and methods: Patients with idiopathic PD registered in the National Parkinson's Disease Patient Registry (PARKreg), with registrations of Hoehn and Yahr (H&Y) and “off time” in the Skåne Region, were
Drawing on interviews with selected UK planning academics and survey results from current planning practitioners, this article provides valuable and timely perspectives on how internationalisation is experienced by those within and beyond the immediate institutional context. Although internationally focused planning education helps planners tackle the manifold urban challenges in the global South,
BACKGROUND: Conventional dosages of cytostatics in mg/m2 will cause marked variations in systemic exposure, resulting in over- and under-treatment, at least with respect to side effects.PATIENTS AND METHODS: We are conducting a randomized adjuvant study for breast cancer patients younger than 60 years of age with > or = 70% risk of recurrence within five years. The first 89 consecutive patients wh
The goal of the HIBEAM/NNBAR program is to search for baryon number violation via the conversion or oscillation of neutrons into sterile neutrons and/or antineutrons at the European Spallation Source. A key experimental component of the program is the construction of an annihilation detector to directly observe the production of an antineutron following the oscillation. Design studies for the anni
The Member States’ external action, including the conclusion of mixed agreements, is constrained not only by an obligation to conform to EU law as it is but also by an obligation to foresee or anticipate its future developments. The latter may concern either changes in legislation or policy, or the case law of the Court of Justice. Foreseeability demands anticipation or awareness of a future event
It is unclear whether neuromuscular electrical stimulation (NMES) has meaningful metabolic effects when users have the opportunity to self-select the intensity to one that can be comfortably tolerated. Nine healthy men aged 28 6 9y (mean 6 SD) with a body mass index 22.3 6 2.3 kg/m2 completed 3 trials involving a 2-h oral glucose tolerance test whilst, in a randomised counterbalanced order, (1) si
Technology has become a vital part of people’s lives. Mobile phones, smart phones, social media platforms, apps and other internet-connected devices and software have changed our way of interacting with each other, as well as managing everyday tasks. In this article, the use of such technology is discussed in relation to its integration in the lives of women who are victims of domestic violence. TTechnology has become a vital part of people’s lives. Mobile phones, smart phones, social media platforms, apps and other internet-connected devices and software have changed our way of interacting with each other, as well as managing everyday tasks. In this article, the use of such technology is discussed in relation to its integration in the lives of women who are victims of domestic violence. T
