Filetype
Accumulation of the tumour-suppressor protein p53 in breast cancer is associated with several prognostic factors that indicate an aggressive, rapidly proliferating tumour with an unstable genome. To assess p53 accumulation in stage I breast cancer and to evaluate the prognostic value of both nuclear and cytoplasmic p53, 205 patients with node-negative breast cancer and tumour size less than or equ
Functional p53 protein is essential for the cellular response to drug-induced DNA damage. We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. Of the tumours from 139 patients, 20 showed abnormal accumulation as judged with immunohistochemistry (> 10% positive tumour cells).
To examine longitudinal trajectories of pain occurrence in children with cerebral palsy (CP) aged 1 year to 17 years.A longitudinal register-based study was conducted using data from the Swedish Cerebral Palsy Follow-up Program (2007-2023). Individuals (n = 4887) with confirmed CP, a minimum of three pain assessments, and any Gross Motor Function Classification System (GMFCS) levels were included
PurposeTo explore the cultural embeddedness of (un)welcome experiences among ethnically marginalized consumers in retail spaces.Design/methodology/approachDrawing on Arjun Appadurai's notion of the ethnoscape, the study is empirically grounded in critical-incident interviews with consumers from multiethnic backgrounds in Sweden.FindingsThree dimensions through which (un)welcome is negotiated are i
Indolent lymphomas pose a challenge in diagnostics through fine needle aspirations due to their similarities to benign growths on a microscopic level. For a proper diagnosis, the patient has to endure a more invasive surgery for extraction of lymphatic tissue through which indolence can be determined. The hypothesis was that diagnostics of indolent lymphomas using only the less invasive fine needl
This thesis examines how outnovation is enacted within design entrepreneurship, with fashion design entrepreneurship as the empirical context. It analyses how value formed through design practice may contribute to sustainable competitive advantage. Understood as an alternative innovation logic centred on authenticity, nostalgia, simplicity, and sustainability, outnovation offers a counterpoint to
Food intake induces metabolic and hemodynamic changes, but its impact on many circulating protein biomarkers remains unclear. This study assessed the effect of a standardised meal on 85 plasma biomarkers measured by the Proseek Multiplex Metabolism panel. Twenty-two healthy adults (11 men, 11 women; mean age 25.9 ± 4.2 years) were examined after an overnight fast and at 30 and 120 min following a
BACKGROUND: Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor in adults. While immune evasion is a well-recognized driver of GBM progression and a major obstacle for efficient immunotherapy, the role of the complement system remains underexplored. C1-inhibitor (C1-INH), a regulator of complement activation, was recently found overexpressed in GBM. We therefore hypothesized
Studying the full universe of nearly 390,000 French patents filed between 1791 and 1900, I show that the nineteenth-century gender patenting gap arose less at the patent office than through unequal access to practical knowledge, collaborators, and time across the life course. I identify 4,165 women inventors using gender-specific honorifics, classify patents with machine learning, reconstruct the
Structured Abstract Background Sexual health and functioning are significant, yet often overlooked, components of psychosocial well-being of adults with congenital heart disease (ACHD). Prior research reports inconsistent findings, limited data on older adults with CHD, and few studies have compared patients with controls from the general population. This study investigated sexual functioning in m
We consider two optimization problems in which a planner aims to influence the average transient opinion in the Friedkin-Johnsen dynamics on a network by intervening on the agents' innate opinions. Solving these problems requires full network knowledge, which is often not available because of the cost involved in collecting this information or due to privacy considerations. For this reason, we foc
This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reportin
Children undergoing surgery for posterior fossa tumours (PFT) may experience postoperative language and communication difficulties, regardless of whether they develop cerebellar mutism syndrome (CMS) or not. While these language difficulties are increasingly recognised in current research, children’s own experiences of everyday communication remain limited. In this presentation, we share findings
This chapter reviews the imaging findings of different non-infectious inflammatory diseases that affect the central nervous system, with special emphasis on demyelinating disorders, such as multiple sclerosis, neuromyelitis optica and acute disseminated encephalomyelitis. Special sections are also dedicated to inflammatory vascular disorders and to metabolic and toxic conditions that affect the ad
Förtätning av städer med en hög andel hårdgjorda ytor i kombination med klimatförändringarna gör urbana miljöer särskilt sårbara. Hållbar dagvattenhantering kan bidra till att öka klimatresiliensen i städerna, samtidigt som de genererar flera mervärden. Vilket gör de särskilt lämpliga i städerna där tillgången till mark är en begränsad resurs. Syftet med detta examensarbete är att tillvarata på inUrban densification with a high proportion of impervious surfaces, in combination with climate change, makes urban environments particularly vulnerable. Sustainable stormwater management can contribute to increasing climate resilience in cities, while also generating multiple added values. This makes such solutions particularly suitable in cities where access to land is a limited resource. The pur
In this thesis we study extensions of the classical Sylow theory from finite groups to the class of locally finite groups. To this end we present theorems from P. Hall as an introduction to π-groups in finite groups and theorems from A. O. Asar and B. Hartley to introduce Sylow theory in locally finite groups. We then conclude the thesis with touching on more well-behaved groups (for example solub
