Type 2 diabetes mellitus (DM2) is characterized metabolically by defects in both insulin secretion and insulin action, resulting in hyperglycemia. Histopathologically, DM2 is characterized by depositions of protein in the pancreatic islets. This 'islet amyloid' is present in > 90% of patients with DM2, as well as in monkeys and cats with DM2. The pathogenesis of DM2 is heterogeneous and multifacto

Popular Abstract in Swedish Små, trådlösa och portabla apparater utgör idag en stor del av vår uppkopplade värld. Under det senaste decenniet har dock flera teknologiska framsteg lett mot en utveckling där allt från maskiner till kläder kommunicerar med varandra. Detta brukar kallas för "sakernas internet" och uppskattas involvera 50 miljarder enheter år 2020. Genom att förse dessa enheter med småThe modern small devices of today require cheap low power radio frequency (RF) transceivers that can provide reliable connectivity at all times. In an RF transceiver, the analog-to-digital converter (ADC) is one of the most important parts and it is also one of the main power consumers. There are several architectures for implementing an ADC, but in the last decade, continuous-time Delta-Sigma mod

Objective IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies. Design We conducted a GWA study (GWAS) of IBS in a general population sample of 11 326 Swedish twins. IBS cases (N=534) and asymptomatic controls (N=4932) w

Experimental work in turbid media has shown that transillumination images can be significantly improved by limiting light collection to a subset of photons which are minimally distorted by scattering. The literature details numerous schemes (commonly termed ballistic imaging), most often based on time-gating and/or spatially filtering the detected light. However, due to the complex nature of the d

This study presents how a TiO2(B) film exposing the (001) face can be grown on Au(111) by chemical vapor deposition. Identification and characterization of the TiO2(B)(001) layer are carried out with low-energy electron diffraction (LEED), synchrotron radiation photoelectron spectroscopy (PES), scanning tunneling microscopy (STM) and X-ray absorption spectroscopy (XAS). Formation of the TiO2(B) fi

Making use of 36 pb(-1) of proton-proton collision data at root s = 7 TeV, the ATLAS Collaboration has performed a search for diphoton events with large missing transverse energy. Observing no excess of events above the Standard Model prediction, a 95% Confidence Level ( CL) upper limit is set on the cross section for new physics of sigma < 0.38-0.65 pb in the context of a generalised model of gau

Objective The aim of this study was to describe the frequency, attribution, outcome and predictors of seizures in systemic lupus erythematosus (SLE). Methods The Systemic Lupus International Collaborating Clinics, or SLICC, performed a prospective inception cohort study. Demographic variables, global SLE disease activity (SLE Disease Activity Index 2000), cumulative organ damage (SLICC/American Co

Introduction A study was undertaken to test the hypothesis that musculoskeletal pain is associated with low vitamin D levels but the relationship is explained by physical inactivity and/or other putative confounding factors. Methods Men aged 40-79 years completed a postal questionnaire including a pain assessment and attended a clinical assessment (lifestyle questionnaire, physical performance tes

Popular Abstract in Swedish Offentlig upphandling blir alltmer intressant och relevant som ämnesområde då dess sanna ekonomiska värde och potentiella inverkan på marknader - genom köpkraft – uppdagas. Det har dessutom blivit ett relevant område för hållbarhetsdiskursen då man har kommit att inse möjligheten att ställa miljökrav inom ramen för den offentliga upphandlingen, samt miljöanpassa upphandIn Sociology of Law the discussions about regulation have been extensive and the issue of public procurement is gaining momentum as its true financial value and potential to impact markets are realised. This thesis aims to look at the regulation of green public procurement (GPP) by analysing findings from an in-depth case study in a Swedish context, using interviews with procurement officers as we

The objectives and methodology of the EU-funded research project HYVOLUTION devoted to hydrogen production from biomass are reviewed. The main scientific objective of this project is the development of a novel two-stage bioprocess employing thermophilic and phototrophic bacteria, for the cost-effective production of pure hydrogen from multiple biomass feedstocks in small-scale, cost-effective indu

Large (>1 m) deformable mirrors are attractive for adaptive optics on ground-based telescopes; the mirrors typically have hundreds or thousands of actuators. The use of force actuators instead of position actuators has the potential to significantly reduce total system cost. However; the use of force actuators results in many lightly-damped structural resonances within the desired bandwidth of the

BACKGROUND: Systolic blood pressure (SBP) decline has been reported in octogenarians. The aim was to study if it could be observed while measuring SBP with two methods: Korotkoff (K-BP) and Strain-Gauge-Finger-Pletysmography (SG-BP), and which of them were more reliable in expressing vascular burden. METHODS: A cohort of 703 men from a population of Malmö, Sweden, were included in "Men born in 19

We compared eelgrass Zostera marina communities in 3 regions in Sweden believed to be affected by eutrophication and overfishing, to determine whether bottom-up or top-down processes control the biomass of epiphytic macroalgae and grazers. Nitrogen and carbon isotope signatures were analyzed to explore the food webs and to identify the grazing species feeding on filamentous algae and/or eelgrass.

Background: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Pr

In this study, we compare two evolving techniques for obtaining high-resolution 3D anatomical data of a mouse specimen. On the one hand, we investigate cryotome-based planar epi-illumination imaging (cryo-imaging). On the other hand, we examine X-ray phase-contrast micro-computed tomography (micro-CT) using synchrotron radiation. Cryo-imaging is a technique in which an electron multiplying charge

Context Agile software development has become popular in the past decade without being sufficiently defined. The Agile principles can be instantiated differently which creates different perceptions of Agility. This has resulted in several frameworks being presented in the research literature to evaluate the level of Agility. However, the evidence of their actual use in practice is limited. Objec

Popular Abstract in Swedish Södra Regionvårdsnämnden har önskat att få belyst om vi har en rättvis och jämlik cancervård i Södra sjukvårdsregionen. Därför har en populationsbaserad registerstudie med många olika etapper genomförts. Basinformationen har hämtats från Tumörregistret i Södra sjukvårdsregionen. Första diagnosdatum noterades och hemort (kommun, distrikt, län) samt sjukhus definierades eThe overall aim was to study different aspect of health care use and health care costs on a population based level for persons with cancer and their partners, and from an individual level to explore the impact of comorbidities in incidence and survival. In the beginning of the study all persons in the Southern Health Care Region in Sweden diagnosed with colon, rectal, breast, prostate and lung can

Objective: No method has yet been established to summarise different objective indicators of social outcomes into one score. The study aimed to develop and test a simple, brief and meaningful index of social outcomes that can be used across a broad range of mental health studies and is potentially obtainable from routine documentation. Method: An index capturing employment, accommodation and livin