In KEYNOTE-564, adjuvant pembrolizumab, a PD-1 antibody, significantly improved disease-free survival (DFS) in localised clear-cell renal cell carcinoma (ccRCC) with a high risk of relapse. In 2021, the European Association of Urology RCC Guidelines Panel issued a weak recommendation for adjuvant pembrolizumab for high-risk ccRCC as defined by the trial until final overall survival data and result

Acute myeloid leukemias (AMLs) are overlapping hematological neoplasms associated with rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification and risk stratification are critical for treatment decisions. A group with expertise in the clinical, pathologic, and genetic aspects of these disorders developed the International Consensus Classification (ICC) of acu

The Cherenkov Telescope Array (CTA) observatory is the next generation of ground-based imaging atmospheric Cherenkov telescopes (IACTs). Building on the strengths of current IACTs, CTA is designed to achieve an order of magnitude improvement in sensitivity, with unprecedented angular and energy resolution. CTA will also increase the energy reach of IACTs, observing photons in the energy range from

AIMS: This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors. METHODS AND RESULTS: EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nut

Patient-reported outcome measures (PROMs) are the only systematic approach through which the patient's perspective can be considered by surgeons (in determining a procedure's efficacy or appropriateness) or healthcare systems (in the context of value-based healthcare). PROMs in registries enable international comparison of patient-centered outcomes after total joint arthroplasty, but the extent to

Giant cell arteritis (GCA) that affects older patients is an independent risk factor for thromboembolic events. The objective of this study was to identify predictive factors for thromboembolic events in patients with GCA and develop quantitative predictive tools (prognostic nomograms) for pulmonary embolism (PE) and deep venous thrombosis (DVT). A total of 13,029 patients with a GCA diagnosis wer

Let R be a commutative artinian ring. We extend higher Auslander correspondence from Artin R-algebras of finite representation type to dualizing R-varieties. More precisely, for a positive integer d, we show that a dualizing R-variety is d-abelian if and only if it is a d-Auslander dualizing R-variety if and only if it is equivalent to a d-cluster-tilting subcategory of the category of finitely pr

BACKGROUND: KRAS mutation can alter the treatment plan after resection of colorectal cancer. Despite its importance, the KRAS status of several patients remains unchecked because of the high cost and limited resources. This study developed a deep neural network (DNN) to predict the KRAS genotype using hematoxylin and eosin (H&E)-stained histopathological images. STUDY DESIGN: Three DNNs were c

Sense of Coherence (SOC), comprising comprehensibility, manageability and meaningful-ness, is important for the sense of living a good life with Late Effects of Polio (LEoP). However, there is a lack of knowledge about the meaning of these three components. The aim of this study was to explore in-depth the meaning of SOC among persons living with LEoP, in terms of comprehensibility, manageability

Traumatic brain injury (TBI) is a major global health issue, with outcomes spanning from intracranial bleeding, debilitating sequelae, and invalidity with consequences for individuals, families, and healthcare systems. Early diagnosis of TBI by testing peripheral fluids such as blood or saliva has been the focus of many research efforts, leading to FDA approval for a bench-top assay for blood GFAP

This article draws on theories of normative control and critical management studies to investigate caseworkers’ strategies in correspondence to a new leadership philosophy in the Swedish Public Employment Service called self-leadership. Based on 43 interviews and observations at two local offices, we find that managerial models are arbitrary and cause uncertainty at the local level as caseworkers

The rewriting of hagiographical texts was a common activity in Byzantium. From at least the ninth century until the end of the Byzantine era, ecclesiastical and non-ecclesiastical writers turned repeatedly to this form of writing, in some cases evidencing an astonishingly prolific textual output. Metaphrasis is the only word found in Byzantine titles to indicate a rewritten text but never used to

Deuterium quartet (Bruno Andersen - vevlira, Lisa Gerholm - Nyckelharpa, Fredric Bergström - vevlira, Katt Hernandez - F# violin) playing a composition/improvisation structure in Mimerlaven, at the Norberg festival. Tis work was made collaboratively.

OBJECTIVE: To investigate feasibility and target engagement of high-dose, add-on pramipexole treatment in anhedonic depression.METHOD: In this open-label pilot study, we included 12 patients with unipolar or bipolar, moderate-to-severe depression and with significant anhedonia symptoms. All patients were on a stable dose of one or a combination of antidepressants and/or mood stabilizers and receiv

This chapter sets the scene for the Handbook by examining definitions of sustainable transport and explaining the rationale and structure of the book. The four parts of the book are outlined, including the brief that authors were given for their contributions to the book.