The proton has a substructure in terms of parton cascades, which in a high energy collision fills the whole rapidity range between projectile and target. In the Good–Walker formalism the fluctuations in the cascades will give rise to diffractive excitation. Within the Lund Dipole Cascade model, it is in this way possible to reproduce diffractive excitation in pp collisions and DIS. In central pp c

This is the report of the work for project Dagsljuskrav i miljöcertifierade byggnader" of the Swedish Energy Agency, project number: 39682-1. The study was focused on the energy use and daylight conditions in the multi-family building Greenhouse located in Malmö, Sweden. The aim of the study was first to analyze and develop innovative design solutions for multi-family dwellings with good daylighti

This is the report of the work carried out for project "Dagsljusanvändning i byggnader" of the Swedish Energy Agency, project number 41816-1. This research provides background scientific information on the daylight performance of multi family apartment blocks located in Stockholm, and Örebro, Sweden. A sample of 54 buildings that consist of 10 888 individual rooms was evaluated using advanced dayl

What can we learn from embryogenesis to increase our understanding of how regeneration of damaged adult lung tissue could be induced in serious lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and asthma? The local tissue niche determines events in both embryogenesis and repair of the adult lung. Important constituents of the niche are extrace

The glycosaminoglycan dermatan sulfate (DS) is a well-known activator of heparin cofactor II-dependent inactivation of thrombin. In contrast to heparin, dermatan sulfate has never been prepared recombinantly from material of non-animal origin. Here we report on the enzymatic synthesis of structurally well-defined DS with high anticoagulant activity. Using a microbial K4 polysaccharide and the reco

Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human commensal commonly residing in the nasopharynx of preschool children. It occasionally causes upper respiratory tract infection such as acute otitis media, but can also spread to the lower respiratory tract causing bronchitis and pneumonia. There is increasing recognition that NTHi has an important role in chronic lower respiratory

myo-Inositol hexaphosphate, the salt of myo-inositol hexaphosphoric acid (IP6), is a common constituent of many plant foods, such as cereals and legumes. IP6 interacts with mineral elements, influencing their bioavailability. Processed foods contain a mixture of different inositol phosphates, i.e., IP6 and its degradation products with five or less phosphate groups (IP5-IP1). The interaction of th

PURPOSE: Disruption of splicing motifs by genetic variants can affect the correct generation of mature mRNA molecules leading to aberrant transcripts. In some cases, variants may alter the physiological transcription profile composed of several transcripts, and an accurate in vitro evaluation is crucial to establish their pathogenicity. In this study, we have characterized a novel PALB2 variant c.

PURPOSE: Few and small studies have been reported about multigene testing usage by massively parallel sequencing in European cancer families. There is an open debate about what genes should be tested, and the actionability of some included genes is under research.METHODS: We investigated a panel of 34 known high/moderate-risk cancer genes, including 16 related to breast or ovarian cancer (BC/OC) g

In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome.

Lebanon has a highly fragmented health care system. The Lebanese population receives its health care services through a system dominated by the private sector that is dependent to a large extent on public sector financing. Lebanon spends about 83% of its Gross Domestic Product (GDP) on health. This study consists of observations on the utilization of the Ministry of Public Health (MOH) program of