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An Unusual Presentation of Lupus Vulgaris and the Practical Usefulness of Dermatoscopy

We report a case report of lupus vulgaris (LV) presented on the extremities of an 80-year-old man. He was misdiagnosed as having psoriasis and referred to our department for a second-opinion evaluation. The discrepancy between the clinical manifestation which was misleading and the dermatoscopic findings raised the suspicion of an underlying granulomatous disease and we proceeded to skin biopsy. T

Secukinumab efficacy on resolution of enthesitis in psoriatic arthritis : pooled analysis of two phase 3 studies

BACKGROUND: Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD: Assessments of enthesitis through week 104 used the Leeds Enthesitis Index. These post

Introduction: The Circulation of Knowledge and the History of Humanities

The term “history of knowledge” has gained traction in recent years. This forum section seeks to explore a prominent concept in this new field—circulation—as well as to demonstrate the value of studying knowledge circulation for the history of humanities. While the study of the transmission of knowledge has been pursued in adjacent fields, such as the history of science or media studies, it is arg

Gaze position regulates memory accessibility during competitive memory retrieval

While previous research has demonstrated that gaze position can increase the accessibility of previous memories when reconstructing the past (Johansson & Johansson, 2014), the present study tested whether such gaze behavior can assist in selecting target memories in the face of competing memories. An adapted retrieval practice paradigm was used, where participants were engaged in selective ret

Hydrologic evaluation of TRMM and GPM IMERG satellite-based precipitation in a humid basin of China

Tropical Rainfall Measurement Mission (TRMM) is one of the most popular global high resolution satellite-based precipitation products with a goal of measuring precipitation over the oceans and tropics. However, in recent years, the TRMM mission has come to an end. Its successor, Global Precipitation Measurement (GPM) mission was launched to measure the earth's precipitation structure, with an aim

The environmental sustainability of nations : Benchmarking the carbon, water and land footprints against allocated planetary boundaries

Growing scientific evidence for the indispensable role of environmental sustainability in sustainable development calls for appropriate frameworks and indicators for environmental sustainability assessment (ESA). In this paper, we operationalize and update the footprint-boundary ESA framework, with a particular focus on its methodological and application extensions to the national level. By using

Self-assembly in ganglioside-phospholipid systems : The co-existence of vesicles, micelles, and discs

Ganglioside lipids have been associated with several physiological processes, including cell signaling. They have also been associated with amyloid aggregation in Parkinson’s and Alzheimer’s disease. In biological systems, gangliosides are present in a mix with other lipid species, and the structure and properties of these mixtures strongly depend on the proportions of the different components. He

The catalytic acid-base in GH109 resides in a conserved GGHGG loop and allows for comparable α-retaining and β-inverting activity in an N-acetylgalactosaminidase from Akkermansia muciniphila

The study describes the first glycoside hydrolase that exhibits comparable levels of activity on α- and β-linked saccharide substrates. This enzyme, assigned into GH109, is encoded by the genome of the human gut symbiont Akkermansia muciniphila that is a model primary degrader of the heavily O-glycosylated mucin glycoprotein that coats the epithelial enterocytes.The elusive catalytic acid/base cat

Diffusion length of photo-generated charge carriers in layers and powders of CH3NH3PbI3 perovskite

The diffusion or transport lengths of photo-generated charge carriers in CH3NH3PbI3 layers (thickness up to 1 μm) and powders have been directly measured with high accuracy by modulated surface photovoltage after Goodman. The values of the diffusion lengths of photo-generated charge carriers ranged from 200 nm to tenths of μm. In thin CH3NH3PbI3 layers, the transport lengths corresponded to the la