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It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR) proteins (α1-antitrypsin, α1-antichymotrypsin, ceruloplasmin, complement C3, ferritin, α-fibrinogen, β-fibrinogen, γ-fibrinogen, haptoglobin, hemopexin) in CSF of 1291 subjects along the clinical and biomarker spectrum of AD to investigate the association between infl

Background: Photoallergic contact dermatitis is one of the important parts of photodermatoses. The investigation of choice is photopatch testing. However, reports with photopatch test results from Asian countries are scarce. The objective of this study was to determine the prevalence of positive photopatch test reactions and to ascertain the common photoallergens among Thai patients during 1998-20

Introduction: Exercise-induced bronchoconstriction is due to osmotic stimulus of the airway epithelium and leads to a cascade of biomarker release from several inflammatory cells. Several type 2 (T2) mediators have been linked to exercise-induced bronchoconstriction, but the T2 response per se has not been described during exercise. The aim of this study was therefore to investigate T2 biomarkers

The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H2 exchange. However, there are no strong indications that modern eukaryotic H2 metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin

Just nu finns det en möjlighet för politikerna att lägga om stadsplaneringen så att det blir möjligt att nå FN:s hållbarhetsmål. Det skriver åtta forskare som arbetar med miljö- och hälsofrågor.

Dataharmonisering är en förutsättning för smarta städer, för ett mer effektivt informationsflöde i samhällsbyggnadsprocessen och för många andra tillämpningar i en stadsmiljö. Vid ett bästa tänkbart scenario kommer dataharmonisering att resultera i ett digitalt informationsflöde som inkluderar information från ett objekts hela livscykel, till exempel för byggnader, vägar och tunnlar. Alla aktörer Data harmonisation is a prerequisite for smart cities, for a more efficient information flow in the planning and building process and for many applications in the urban environment. Ideally, data harmonisation will result in a digital information flow that include information from the whole lifecycle of a feature, for example for buildings, roads and tunnels. All actors and applications involved i

Studien fokuserar på sociala- och organisatoriska aspekter av den digitala arbetsmiljön och hargenomförts av en pedagog och en datavetare i samverkan. Införandet av Canvas som lärplattform haranvänts för att studera implementeringen av ett nytt system som en del av lärares arbetsmiljö.Med material från intervjuer och observationer ges en beskrivning av hur universitetslärararbetetunderlättats och

The present study examines in a quantitative manner the relationship between the attitudes toward gender equality and those toward gender-inclusive language. It also studies how a text written with gender-inclusive language is evaluated and observes what factors can act thereupon. Firstly, statistical analyses show that women have more positive attitudes than men, and that residents in a French-sp

In this paper we present the recent improvements for optically stimulated luminescence dosimetry using ordinary salt (NaCl). It is shown that the dosimetric properties of NaCl may be improved by compressing the salt grains to solid pellets. With a linear dose response in, at least, the region <100 mGy, a zero background signal (when pre-bleached) and a minimum measurable dose of 10-20 μGy and high

Photodoping as a nonvolatile and reversible method can be used to modify the carrier distribution at the heterojunction interface. Herein, we explore the 2D/3D van der Waals (vdW) graphene/silicon (G/Si) heterostructure in real time by terahertz (THz) emission spectroscopy. Photoinduced doping is introduced by a continuous wave laser, which leads to a screening effect to the built-in electric fiel

High diagnostic efficiency as well as the optimization of patient and staff doses in positron emission tomography (PET) can be achieved by implementing quality assurance program. This study was focused on the requirements and basic aspects of quality assurance (QA) in PET combined with computed tomography (CT), that include equipment quality control (QC). QA systems include methods of image QC, ex

We present the first spatially resolved study of molecular gas in the vicinity of a gamma-ray burst (GRB), using CO(2-1) emission-line observations with the Atacama Large Millimetre Array at ∼50 pc scales. The host galaxy of GRB 980425 contains a ring of high column density H i gas, which is likely to have formed due to a collision between the GRB host and its companion galaxy, within which the GR

The growing attention to the negative side-effects of our use of plastics has led to numerous calls for changing the current plastics system. However, there is lack of coherent and systematic assessments of how and in what direction the plastics system should change to become more sustainable. This discussion brief explores five potential pathways: Bio-based, Biodegradable, Recycled, Fewer types a

In this work, the load disturbance rejection problem is studied. Specifically, the feedforward compensators are considered to reduce the effect of the disturbance in the process' performance. The authors propose simple tuning rules that can be easily applied to a wide range of processes improving the response against the disturbance. The improvement of the proposed method is measured through diffe

The compound La24Ru11 (tetracosalanthanum undecaruthenium) crystallizes in a Ce24Co11-type structure. The non-centrosymmetric crystal structure (space group P63 mc) contains RuLa6 trigonal prisms, La6 octahedra and LaRu4 tetrahedra and is closely related to that of Ce23Ni7Mg4. This communication highlights the crystal-chemical similarities and points out the differences between the two structures.

When daylight hours are limited, pedestrians are dependent on appropriate outdoor lighting. Although new city lighting applications must consider both energy usage and pedestrian responses, current methods used to capture pedestrian walking behaviour during dark conditions in real settings are limited. This study reports on the development and evaluation of a video-based method that analyses pedes

Plasticity can put evolution on repeat if development causes species to generate similar morphologies in similar environments. Anolis lizards offer the opportunity to put this role of developmental plasticity to the test. Following colonization of the four Greater Antillean islands, Anolis lizards independently and repeatedly evolved six ecomorphs adapted to manoeuvring different microhabitats. By