Background: Polymorphisms in and around the CTLA-4 gene have previously been associated to TiD and AITD in several populations. One such single nucleotide polymorphism ( SNP), CT60, has been reported to affect the expression level ratio of the soluble ( sCTLA- 4) to full length CTLA- 4 ( flCTLA- 4) isoforms. The aims of our study were to replicate the association previously published by Ueda et al

This study applies Closed-Loop Combustion Control (CLCC) using Fast Thermal Management (FTM) on a multi-cylinder Variable Compression Ratio (VCR) engine together with load control, to achieve a favorable combustion phasing and load at all times. Step changes of set points for combustion phasing, Compression Ratio (CR), and load together with ramps of engine speed with either constant load, i.e., l

Human cystatin C, a protein with amyloidogenic properties and a potent inhibitor of papain-like mammalian proteases, has been produced in its full-length form by recombinant techniques and crystallized in two polymorphic forms: cubic and tetragonal. A selenomethionyl derivative of the protein, obtained by Escherichia coli expression and with complete Met→Se-Met substitution confirmed by mass spect

Seed bank is a plant life history strategy against the unpredictability of the biotic and the abiotic environment. We simulated competition between a seed banking and a non-banking morph of an annual plant. A constant fraction of the banker morph seeds was allocated to the seed bank, where they had a constant mortality and germination rate. All surviving seeds of the non-banker morph germinated in

The paper is based on an inventory of crofts and cottages that was made in the parish of Länghem in the southern part of the province of Västergötland, Sweden at the end of the 1950ies and the beginning of the 1960ies. The parish of Länghem has both manors (the medieval Torpa and Hofsnäs and the 17th century Sällerås) and independent villages. The inventory was made quite traditionally. We tried t

Effects of A-322312 (alpha(1B)-adrenoceptor (AR) antagonist), A-119637 (alpha(1D)-AR antagonist), prazosin (non-selective alpha(1)-AR antagonist), and yohimbine (alpha(2)-AR antagonist) were studied in rat corpus cavernosum (CC) and cavernous artery (Acc) preparations. Effects of intracavernous (i.c.) or intraperitoneal (i.p.) administration of alpha(1)-AR antagonists on apomorphine-induced erecti

Purpose: We compared ProstaLund Feedback Treatment(R) (PLFT(R)) to transurethral prostate resection (TURP) in terms of efficacy and safety in a pooled analysis of 3 clinical studies with 1-year followup. Materials and Methods: Overall raw data on 183 patients with PLFT(R) and 65 with TURP were pooled. All studies had identical inclusion criteria, and the efficacy and safety of the method were eval

Popular Abstract in Swedish Denna avhandling sammanfattar arbete där tidsupplöst röntgendiffraktion har använts för att undersöka kristallina material och studera dynamiken hos fononer och fasövergångar. Röntgendiffraktion är standardverktyget för stukturbestämning på en atomär skala. Det har använts länge och har framgångsrikt hjälp vetenskapsmän att bestämma strukturen hos en stor mängd materiaThis thesis summarizes work in which time-resolved X-ray diffraction has been used to probe crystalline materials, thereby revealing the dynamics of phonons and phase transitions. X-ray diffraction is the standard tool in investigations of structure on the atomic scale. It has been used for a long time, and has successfully helped scientists to find the structure of a wide range of materials. The

Huntington's disease is an autosomal dominant neurodegenerative disorder caused by an expanded CAG repeat. It is characterized by motor and cognitive disturbances, as well as cellular dysfunction and loss in the basal ganglia and the cerebral cortex. The mutant protein huntingtin aggregates in cells. The toxicity of mutant huntingtin, or the loss of its normal function, causes disruption of cellul

The "European Guidelines on Quality Criteria for Diagnostic Radiographic Images" do not address the choice of the film characteristic (H&D) curve, which is an important parameter for the description of a radiographic screen–film system. The image contrast of clinical lumbar spine and chest radiographs was altered by digital image processing techniques, simulating images with different H&D

Aim: To identify maternal prenatal and postnatal smoking as risk factors for psychosocial behaviour problems in Swedish preschool children. Methods: This prospective, longitudinal population study compared mothers' self-reported smoking during pregnancy and when the child was 3 mo old with behaviour problems according to Achenbach's Child Behavior Checklist at 3 y ( 1428 children) and 5.5 y of age

Aims and objectives. This study aimed at investigating life satisfaction and its relation to living conditions, overall health, self-care capacity, feeling lonely, physical activities and financial resources among people (65+) with reduced self-care capacity. Background. Knowledge about factors related to low life satisfaction among older people with reduced self-care capacity is sparse, although

In dilute astrophysical plasmas, such as planetary nebulae and H II regions, strong lines appear that only have weak, if any, correspondence to the spectrum of laboratory light sources. Some of these are parity forbidden lines, i.e. emission from long-lived metastable states that cannot decay via normal electric dipole (E1) routes but only via the slower M1 and E2 transitions. The long lifetime of