The existing information supports the use of this material as described in this safety assessment. Methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that methyl-2,2-dimethyl-6-methylene-1-cyclohex

Liberal minority of the Georgian population views the Georgian Orthodox Church (GOC) as an obstacle to country’s progress. Overwhelming majority of GOC’s influential clerics are (fairly) seen as resistant to the idea(l)s of equality between sexes and gender, individual liberties and generally to critical thinking. The majority of Georgians considers GOC as the most trusted institution, making patr

In the 20 years since Vladimir Putin came to power, Russia has developed a soft power strategy for dealing with Western politics – where Switzerland is not immune. Sociologist Tornike Metreveli looks at some of the evidence.

AbstractBreast cancer incidence is increasing, and despite major progress in the treatment, breast cancer is still the leading cause of death from cancer among women. Thus, there is a constant need for new treatment options. Statins are peroral drugs that have been widely used since the early 1990s, due to their well-documented effect of lowering plasma cholesterol levels and preventing cardiovasc

Background: Patients diagnosed with metastatic breast cancer have poor outcome with a median survival of approximately 2 years. While novel therapeutic options are urgently needed, the great majority of breast cancer research has focused on the primary tumor and less is known about metastatic breast cancer and the prognostic impact of the metastatic tumor microenvironment. Here we investigate the

Enlargements of distal airspaces can indicate pathological changes in the lung, but accessible and precise techniques able to measure these regions are lacking. Airspace Dimension Assessment with inhaled nanoparticles (AiDA) is a new method developed for in vivo measurement of distal airspace dimensions. The aim of this study was to benchmark the AiDA method against quantitative measurements of di

This article is the outcome of two research trips to the Jain caves at Ellora, the purpose of which was to photograph the best preserved murals found there, works of art that were largely undocumented in any available literature. The article documents and portrays the best preserved paintings in detail found on the walls and ceiling of one of the smaller caves belonging to the largest Jain cave coThis article is the outcome of two research trips to the Jain caves at Ellora, the purpose of which was to photograph the best preserved murals found there, works of art that were largely undocumented in any available literature. The article documents and portrays the best preserved paintings in detail found on the walls and ceiling of one of the smaller caves belonging to the largest Jain cave co

Desire for life and protecting lives has come to the fore during the pandemic. Borders have been closed to stop the spread of Covid-19. The virus does not respect borders, yet physical distance is crucial. Three things have become clear. One is the level of uncertainty about which measures are most efficient. The other is that the neo-liberal philosophy with “just in time” deliveries on a global m

The generality problem is commonly considered to be a critical difficulty for reliabilism. In this paper, we present a dynamical perspective on the problem in the spirit of naturalized epistemology. According to this outlook, it is worth investigating how token belief-forming processes instantiate specific types in the biological agent’s cognitive architecture (including other relevant embodied fe

One of the benefits of cooperative hunting may be that predators can subdue larger prey. In spiders, cooperative, social species can capture prey many times larger than an individual predator. However, we propose that cooperative prey capture does not have to be associated with larger caught prey per se, but with an increase in the ratio of prey to predator body size. This can be achieved either b

På senare tid har betydelsen av språk kommit att debatteras med stor iver i offentligheten, inte minst frågan om svenskans ställning i förskola, grundskola och gymnasium. Vikten av en välfungerande språkundervisning gäller hela utbildningskedjan och inte minst för högskolan, skriver bland andra Isak Hammar, fil. dr i historia och verksamhetsledare för tankesmedjan Humtank.

This paper introduces the new ForestValue research project CLICKdesign – delivering fingertip knowledge to enable service life performance specification of wood. This European consortium is working on the primary innovation to move from the complex, fragmented and general to the easy-to-use, consolidated and specific by provision of an accessible digital tool for specifiers. Competing materials ta

The width of a resolution proof is the maximal number of literals in any clause of the proof. The space of a proof is the maximal number of clauses kept in memory simultaneously if the proof is only allowed to infer new clauses from clauses currently in memory. Both of these measures have previously been studied and related to the resolution refutation size of unsatisfiable CNF formulas. Also, the

Objective In this study we aimed to estimate the effect of diabetes, educational level and income on the risk of mortality and cardiovascular events in primary care patients with hypertension. Methods We followed 62,557 individuals with hypertension diagnosed 2001-2008, in the Swedish Primary Care Cardiovascular Database. Study outcomes were death, myocardial infarction, and ischemic stroke, asses

Alzheimer's disease is the most common cause of dementia. As many as 250,000 people in Sweden will have a dementia disease in 2050. The »amyloid cascade hypothesis« is a common model which explains how β-amyloid affects the function of the nerve cells. Alzheimer's disease has a long-lasting course and can present in typical and atypical forms. CSF analyses for »core AD CSF biomarkers« and synaptic