Evaluating the role of DNAJ chaperones on PolyQ aggregation in PolyQ expressing HEK293 cell lines using CRISPR-dCas9 knock-down
Guardian proteins help or hinder clumpy proteins? Proteins are products encoded by DNA in cells. They need to be folded in a certain structure to perform their function in the cell. Because of this, the proteins need a quality control system to ensure that they are folded correctly. A large group of proteins called as chaperones are important in this regard. The main role of chaperones is to fold
