The effects of meniscal substitution with a Dacron® or Teflon® prosthesis on rabbit knee-joint cartilage were studied by indentation tests, gross and histological inspection, analysis of proteoglycan fragments in joint fluid and an evaluation of synovial changes. Cartilage mechanics and cartilage morphology were similarly abnormal after meniscectomy and meniscal substitution. The elevated concentr

Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal

We reviewed reports that describe development of osteoarthrosis of the knee after anterior cruciate ligament or meniscus injury. the occurrence of posttraumatic osteoarthrosis varied considerably from one report to another. the literature does not lend support to the efficacy of cruciate ligament repair or reconstruction in retarding the progression of osteoarthrosis after knee injury. We encourag

Stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1), and proteoglycan fragments were quantified in knee synovial fluid samples in a cross-sectional study of patients who had injury to the anterior cruciate ligament or the meniscus. The average concentrations of stromelysin-1 and TIMP-1 increased 25-fold and 10-fold within the first day after the trauma, respectively, and the concentra

The degree of cartilage changes by arthroscopic and radiologic examination was evaluated in a retrospective, cross-sectional study of 1012 patients with knee complaints at different times after knee injury. Patients were classified by age, sex, trauma date and type of injury. The condition of the cartilage was graded on a 1-10 scale based on findings at arthroscopy and on weight-bearing radiograph

Objective - To assess the effects of intraarticular injections of hyaluronan on symptoms of knee osteoarthritis (OA). Methods - Two hundred and forty patients with symptomatic, radiological knee OA were randomly assigned to treatment with weekly injections for five weeks with either 25 mg of high molecular weight hyaluronan or vehicle. Results were evaluated at weeks 1, 2, 3, 4, 5, 13, and 20 by v

Deep flexor tendons of 30 rabbits were divided at the ankle level. The effects of unloading on the synthesis and content of matrix components, the synthesis of DNA, and dry weight were investigated. The reaction of the fibrocartilaginous and non-fibrocartilaginous segments were separately analyzed. The ability of the tendons to synthesize collagen during short-term culture and the contents of matr

There is broad consensus that good outcome measures are needed to distinguish interventions that are effective from those that are not. This task requires standardized, patient-centered measures that can be administered at a low cost. We developed a questionnaire to assess short- and long-term patient-relevant outcomes following knee injury, based on the WOMAC Osteoarthritis Index, a literature re

While the term public diplomacy (PD) has undergone a major revival in the early 21st century, the evaluation of PD programs has not been given anywhere near the same level of attention. The number of studies which consider either the methods used for the evaluation of PD campaigns or the theoretical grounds of PD evaluation methodologies remain few compared to the number which discuss PD policy or

The book looks at corporate voluntarism from a socio-legal perspective and places CSR in a regulatory context. The responsible practices of leading businesses have a role in the rule-making process by clarifying general, flexible concepts such as ‘due diligence’, ‘reasonability’, ‘foreseeability’ which all have a bearing on findings of corporate ‘negligence’. Procedural regulations seeking to enco

The book looks at corporate voluntarism from a socio-legal perspective and places CSR in a regulatory context. The responsible practices of leading businesses have a role in the rule-making process by clarifying general, flexible concepts such as ‘due diligence’, ‘reasonability’, ‘foreseeability’ which all have a bearing on findings of corporate ‘negligence’. Procedural regulations seeking to enco

Prof. Ruggie’s work, with the ‘Protect, Respect and Remedy’ Framework (2008) and Guiding Principles (2011) as its peak, is multilayered and comprehensive. Instead of a dry, tedious description this introductory chapter will give the floor often to the SRSG: readers will find numerous quotations and references that will allow him or her to follow Ruggie’s reasoning. Ruggie should be commended for t

This chapter discusses the treatment that Professor Ruggie’s Guiding Principles offer for the responsibility to respect human rights (RtR) as applied to core companies whose affiliates’ operations infringe human rights. The issue is about a core company’s responsibility to act to address abuses that occur towards the periphery of its group or network. The fairness of globalisation is often questio