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The role of CTCF and cohesin in high hyperdiploid childhood acute lymphoblastic leukemia
Chromosome defects in high hyperdiploid childhood acute lymphoblastic leukemia Acute lymphoblastic leukemia (ALL) is a type of blood cancer that affects both adults and children. While human cells normally harbor 46 chromosomes, the leukemic cells of the high hyperdiploid subgroup (HeH) of childhood ALL presents 51-67 chromosomes, where the extra chromosomes are generally X, 4, 6, 10, 14, 17, 18
Transient Plasma Photonic Crystals - A Route Towards Slow Ultra-intense Light?
Långsamma pulser är intressanta för acceleration av till exempel protoner. Protoner som accelereras till höga hastigheter kan i förlängningen användas till mer skonsam behandling av cancer, där en större del av energin dödar cancercellerna istället för friska celler runt om. Det är emellertid mycket svårt att få protoner att färdas i de hastigheter som krävs. Konventionella partikelacceleratorer äPeriodic electron and ion density modulations in near critical density plasmas induced by counterpropagating femtosecond pulses of intensities on the order of 10¹⁵ to 10¹⁶ Wcm⁻² are described in a linear and stationary regime and investigated using particle-in-cell simulations in one and two dimensions. The periodic gratings produce transient plasma photonic crystals lasting up to several picoseco
Home ranges and temporal land tenure of Sunda clouded leopards (Neofelis diardi subsp.borneensis) in Indonesian Borneo
Little is known about the spatial ecology of the Sunda clouded leopard (Neofelis diardi). Being rare and elusive rainforest dwellers, studying them is difficult. Basic knowledge on their home ranges and social organization is lacking, yet is crucial for maintaining viable populations in protected areas, in the scope of this Vulnerable species’ conservation. This study uses 10 years’ worth of came
Erfarenhetsåterföring i projekteringsfasen - En fallstudie av vanligt återkommande projekteringsfrågor
Problemställning: - Vilka är de vanligast återkommande projekteringsfrågorna inom visuell projektering? - Vilka utmaningar står ett byggentreprenörföretag inför gällande erfarenhetsåterföring i projekteringsfasen? - Hur kan återkommande projekteringsfrågor i den visuella projekteringen bidra till erfarenhetsåterföring? Syfte: Syftet med den här studien var att undersöka om det förekom frågor
Spatio -Temporal Modelling of Air Pollution in Malta
Air pollution has become a major worldwide concern due to the high levels of air pollutants emitted from industrial and traffic related activities. Exposure to air pollution has been linked to various negative health effects, ranging from asthma to chronic illnesses. Consequently, analyzing air pollution data has become an essential tool for giving insight about the potential health effects. Spati
Multi-scale modelling of fire in accelerator tunnels: a CERN case study
Multi-scale modelling is a novel approach to fire modelling in situations where the size of the domain prevents it from being modelled completely in 3D. By splitting the domain in a 1D and 3D portion multi-scale modelling allows for much faster simulations which still adhere to the correct boundary conditions. In this thesis the multi-scale methodology is applied to the LHC accelerator in use at C
A Case Study to Investigate how Beta Product Marketing can Test the Validity of a Product’s Market Potential
Många entreprenörer och startup kommer till en punkt när de har slutfört utvecklingen av en produkt men flyttar sedan till den fas som är avgörande för en produkts framgång, marknadsföringsbiten. Stora investeringskostnader i kombination med osäkerheten om den utvecklade produktens marknadsvärde är orsaken till många produkters misslyckanden. Detta leder till att många nya produkter aldrig når marMany entrepreneurs and start-ups come to the point when they have finished the development of a product but then moves to the phase which is crucial for a products success, the marketing effort. Large investment costs combined with the uncertainty of the developed product's market value is the reason for many products failure. Thus, many new products never reach the market because of the lack
Determining splicing of probably, possibly and high-risk human papillomavirus and identification of regions controlling splicing of HPV16 E6/E7 and E2
De cancerorsakande generna skiljer mellan olika humanpapillomvirus Humant papillomvirus (HPV) är en grupp små, välkända virus som har funnits på denna jord sedan Homo sapiens satte sin fot på jorden. Totalt finns det idag över 200 typer men framförallt 20 är av stort intresse, eftersom de kan orsaka cancer hos människor, framförallt livmoderhalscancer. Årligen diagnostiseras runt 500 000 människoHuman papillomaviruses (HPVs) are DNA viruses which have existed on earth since the emergence of mankind. In total there are over 200 different types and twenty of these show a correlation with the development of cancer. These twenty HPVs are divided into high-risk and probable/possible high-risk HPVs depending on the occurrence in carcinoma in situ. Five biomarkers have been set for these twenty
Adopting additional product-life extension strategies - A study of reuse and remanufacturing in the maritime industry
The purpose of this paper is to investigate the potential barriers of adopting additional product-life extension strategies and therefore increase the understanding of this phenomenon. Just as the name implies, product-life extension entails keeping resources in use for as long as possible in order to extract maximum value from them. Specifically, the strategies investigated in this research are r
Habitat Suitability of the Round Goby (Neogobius melanostomus) and the Effect of Marine Protected Areas on its Distribution in the Baltic Sea
Invasive species are one of the leading causes of biodiversity loss worldwide, and effective management of protected areas is one of the primary ways in which conservationists try to limit their impacts and dispersal. The round goby (Neogobius melanostomus) is a problematic invasive species in the Baltic Sea, along with other brackish waters, lakes, and rivers in Europe and North America, having b
Turbinmodellering – En jämförelse av polygonmodellering och komponentmodellering
Abstract In order to be able to calculate how an energy system should be controlled to achieve minimal overall cost in advance,energyproducers often use software for economic operational optimization. In order for the software to make good optimizations, the model of the energy system needs to be realistic. It is also important for the user that optimizations do not take too long and that it is e
Insider Threat detection using Isolation Forest
In contrast to the need for companies to get real time information about insider threats, there is a privacy and integrity based limitation of what the individual accepts as acceptable surveillance. This creates a problem since performing online surveillance would pose an infringement on the employees privacy and integrity. Therefore we present a model using Isolation Forest to solve this problem.
Remittances developmental potential in Mexico
The U.S-Mexico migration corridor has the largest flows of migrants in the world. Mexican migrants send home approximately USD 25 billion annually, making Mexico the fourth biggest remittance receiver in the world. Personal remittances are Mexico’s largest single source of foreign income, as it surpassed oil income in 2014. Some scholars argue that due to the large size of remittances, it holds a
Strategic Planning and Succession in SMEs: A Multiple Case Study on Italian Family Firms
This paper’s goal was to investigate the influence of the degree of formal strategic planning on the pre-and post-succession period within family firms of small and medium size. With a qualitative approach, a multiple-case study was utilized to obtain empirical data from 5 family firms in Italy, in which semi-structured interviews with founders, other family members and non-family managers were co
Modelling News Sentiment Flow Using Spatial Hawkes Processes: Dependencies Between Topics and Countries
This Master Thesis proposes to use a Spatial Hawkes Process to model the news flow in the world. The spatial part is divided in both geographical areas as well as different topics. Therefore, in the Hawkes model every news article corresponds to a point in space and time. In a certain region and topic the intensity of the released articles will be modelled with the Hawkes Process. This can be of i
Interpretation of geophysical and geochemical data in a 3D geological model construction of a contaminated site
The Alingsås dry-cleaning facility is one of the heavily halogenated hydrocarbon contaminated sites in Sweden. The source of contamination dates back to the 1970s when a large scale tetrachloroethylene leakage outbroke inside the dry-cleaning building. After years of propagation and dissemination, the tetrachloroethylene together with its degradation products was widely found in soil and groundwat
Relationen till ett universitets varumärke
Syfte: Syftet med denna studie har varit att studera universitetsstudenters relation till utbildning och lärosäte vid Lunds universitet utifrån ett varumärkesperspektiv Metod: Studien har en kvalitativ inriktning, utgår från ett hermeneutiskt fenomenologiskt synsätt och har huvudsakligen en induktiv karaktär med deduktiva drag. Teoretiska perspektiv: Studien tar sin utgångspunkt i en kombinatiPurpose: The purpose of this thesis has been to examine university students relationship to a university and higher education at Lunds University from a brand perspective. Methodology: The thesis is based on a qualitative approach with a hermeneutic phenomenological orientation. It is characterised by a inductive approach with some deductive elements. Theoretical perspectives: The theoretical
Driverless Cars and Merciless Robots – a comparison between the legal frameworks of autonomous driving and weapon systems.
Artificial Intelligence (AI) technology advances quickly through society, with driverless cars presented as a revolutionary technological advance that can make roads safer and transport more efficient, whereas automated weapons are either viewed as undesirable, or as an unavoidable development. The objective of the present work is to, through the comparison between automated driving and automated
Developing Strategic Thinking Ability: A Study of the Master's in Management and a Metacognition Course
The purpose of this study is to improve the understanding of the ability of educational interventions to improve strategic thinking. It does this both by contributing to the available empirical data on the development of strategic thinking ability and by exploring potential; avenues of research, intervention designs, study designs, sampling issues and analysis problems, for future studies as part