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BACKGROUND: CFTR modulators, including Elexacaftor/Tezacaftor/Ivacaftor (ETI), have markedly improved clinical outcomes for people with cystic fibrosis (pwCF), but the molecular impact on airway inflammation remains incompletely understood. This study aimed to characterise longitudinal changes in airway inflammation and sputum proteomes following ETI treatment.METHODS: Sputum from pwCF (n = 30) wa
Real catalysts consisting of nanoparticles host many nanofacets. Each nanofacet changes its structure and function in response to its local environment but is also affected by neighboring nanofacets. Time-resolved operando experiments close to realistic conditions at polycrystals mimicking real catalyst particles are unfortunately challenging but could be highly rewarding. Here, we demonstrate how
Context: Life satisfaction (LS) is associated with health and longevity but decreases after spinal cord injury (SCI). Yet, little is known about changes in LS over time, many years after SCI. Objectives: To assess changes in LS over six years among older adults aging with long-term SCI, determine how changes in LS are associated with sex, age, injury characteristics, and with changes in secondary
Artikeln analyserar hur Århuskonventionens tredje pelare om allmänhetens tillgång till rättslig prövning har implementerats i svensk rätt och därefter utvecklats genom EU‑domstolens praxis och svenska domstolsavgöranden. Analysen exemplifierar genom att ta sin utgångspunkt i miljöorganisationers talerätt i skogsbruksfrågor. Lagstiftarens ursprungliga intentioner vid införlivandet (särskilt Ds 200
Straw addition is a widely used agricultural practice to maintain soil fertility. However, its effects on soil organic carbon (SOC) and nutrient cycling are complex, with outcomes ranging from inhibition to stimulation of SOC mineralization via the priming effect. Freeze-thaw cycles are common disturbances in agroecosystems of high-altitude regions that are predicted to increase in frequency and s
The Anthropocene thesis, in its rejection of both the modernist separation between ‘humans’ and ‘nonhumans’ as well as in its treatment of ‘humans’ as a singular global geophysical force, presents fundamental challenges to constitutional theory and practice. First, in terms of conceptual and foundational transformations, the Anthropocene provokes the reconceptualisation of legal relations as never
Steeds vaker kiezen landen ervoor om rechtspersoonlijkheid te verlenen aan onderdelen van de natuur. Deze korte bijdrage bespreekt die ontwikkeling tegen de achtergrond van het Antropoceen, het tijdperk waarin menselijke invloeden op de aarde voor mens en natuur bepalender en bedreigender zijn dan de grote natuurkrachten. In zoverre het verlenen van rechten aan de natuur bijdraagt aan het opheffen
The pervasive influence of human agency on biodiversity in the Anthropocene gives rise to several new challenges for national and international wildlife law, including questions regarding what is natural and what is alien. Ultimately, a new vision and new rules are called for but in the meantime wildlife lawyers and other conservation professionals must work with conventional legal frameworks. Str
Free-ranging domestic cats (Felis catus) impact biodiversity through predation, disturbance, competition, disease and hybridisation. Scientific knowledge regarding these impacts has recently increased. This article interprets the European Union (EU) Birds and Habitats Directives (Nature Directives) in light of this knowledge. The outcome indicates that various obligations in the Directives, partic
Neuroenhancement involves the use of neurotechnologies to improve cognitive, affective or behavioural functioning, where these are not judged to be clinically impaired. Questions about enhancement have become one of the key topics of neuroethics over the past decade. The current study draws on in-depth public engagement activities in ten European countries giving a bottom-up perspective on the eth
