Filetype
INTRODUCTION: Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS: We analyzed amyloid-positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dementia Cohort (ADC, N = 1036) and Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 685). Cognitive resilience was conceptualized from a canonical correlation
In Singapore, children’s education is typically presented as “an overriding and all-consuming concern,” fueled by extreme competition for grades and school admissions (Waters 2015: 290). However, parents' desire for academic excellence as a route to better lives is not as straightforward as it may seem. Drawing on ethnographic fieldwork with Singaporean families, this paper explores parents' gende
Mental health assessments increasingly rely on remote formats that produce rich but complex multimodal data in the form of text, audio, and video, processed through multiple machine learning models. While these environments offer new opportunities for insight, they also pose significant challenges for effective clinical sensemaking. This study introduces a dashboard designed to address these chall
Background: Lung cancer screening excludes individuals not considered at an increased risk for lung cancer, as predicted by risk models like the Liverpool Lung Project version 3 (LLPv3). In this study, we sought to validate whether plasma glycosaminoglycan profiles (GAGomes) could predict lung cancer independent of LLPv3 and other prespecified comorbidities. Methods: In this retrospective cohort-b
Background Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. Methods In t
Aim: Clinical trial data have demonstrated that direct oral anticoagulants (DOACs) are both noninferior to and safer than conventional therapy for the treatment of venous thromboembolism (VTE). This study aimed to compare the effectiveness and safety of DOACs versus warfarin using Nordic population-based registries. Materials & methods: This observational cohort study used Swedish, Norwegian a
Particulate methane monooxygenase (pMMO) is an enzyme that converts methane into methanol at ambient temperature and pressure. Over the past three decades, the metal content and location of the active site have been highly controversial. Recent single-particle cryogenic electron-microscopy (cryo-EM) structures have furthered this debate. In this study, three cryo-EM structures (PDB entries 7s4h, 7
Plasma phosphorylated tau (p-tau) biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network d
Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results:
Public health can be immediately and substantially improved by policies that also mitigate climate change over the longer term. However, implementation of these policies has been slowed at least in part by doubts and lack of awareness of these health co-benefits. To address this barrier to progress, we demonstrate how an illustrative set of interventions led to environmental, health, and economic
Background In several countries, whole-body imaging has been introduced in the routine follow-up of individuals with high-risk cutaneous malignant melanoma after surgery. However, there is scarce evidence that earlier detection of recurrent disease by regular scanning improves survival. In this interim analysis, we investigated whether imaging in the follow-up programme for high-risk cutaneous mal
Background: The aim was to explore patients’ reflections related to their choice of participating or not in a multimodal prehabilitation randomised controlled trial (RCT) in relation to minor surgery. Methods: A qualitative study with 22 semi-structured in-depth interviews on patients awaiting ventral hernia repair was conducted between March and May 2024 and reported according to the COREQ guidel
This paper aims to enhance our understanding of how strategic communication mobilise democratic values and ideals, which civil society is expected to support. Drawing on discourse theory, the paper conceptualises strategic communication as a process that unites various publics. This paper argues that these publics are largely imagined and constructed through communication. It also asserts that the
BACKGROUND: The cross-sectional association between cerebral tissue oxygen saturation (SctO 2) and heart failure (HF) has been previously studied, but the prognostic significance of SctO 2 in HF remains uncertain. This study aimed to assess the role of SctO 2 as a risk factor for all-cause mortality and rehospitalisation, as well as to explore the cross-sectional association between physical activ
The distribution of betony (Betonica officinalis L.) is mapped using 390 herbarium specimens from 31 countries (28 European, 2 African and 1 Asian), representing ca 200 localities. Populations from 19 of these localities were used in seed cultivation experiments. Characters that correlate with their biogeography were searched for both in the herbarium material and in the cultivated material. Three
Objectives Sustained activity of the upper trapezius muscle during work has been linked to the development of neck pain. Women have higher occurrences of neck pain than men, even in the same occupations. This study aimed to investigate sex-specific associations between upper trapezius muscle activity time-related variables and neck pain using a meta-analysis of pooled data. Methods Seven Scandinav
Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in
The perivascular space (PVS) is integral to glymphatic function, facilitating fluid exchange and waste clearance in the brain. Diffusion tensor imaging along the perivascular space (DTI-ALPS) has been proposed as a noninvasive marker of perivascular diffusion, yet its specificity remains unclear. ALPS measures assume radial symmetry in white matter (characterized by equal transverse diffusion eige
Gut microbial communities can facilitate traits that are essential for invasive species survival in novel environments. Despite the global plethora of invasive social insect species, the role of the gut microbiome in colonisation success under novel dietary and environmental conditions is little known. The introduction of the European buff-tailed bumblebee, Bombus terrestris, to the island of Tasm
