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BackgroundWe introduce and apply an elegant, contrastive genetic-epidemiological design - Maternal Half-Sibling Families with Discordant Fathers - to clarify cross-generational transmission of genetic risk to alcohol use disorder (AUD), drug abuse (DA) and major depression (MD).MethodUsing Swedish national registries, we identified 73 108 eligible pairs of reared together maternal half-siblings an
A total of 462 coprolites from three localities exposing Upper Cretaceous deposits in the Münster Basin, northwestern Germany, have been subjected to an array of analytical techniques, with the aim of elucidating ancient trophic structures and predator–prey interactions. The phosphatic composition, frequent bone inclusions, size and morphology collectively suggest that most, if not all, coprolites
We introduce a comprehensive framework for the efficient implementation of finite deformation gradient-regularised damage formulations in existing finite element codes. The numerical implementation is established within a thermo-mechanically fully coupled finite element formulation, where the heat equation solution capabilities are utilised for the damage regularisation. The variationally consiste
A composite Higgs boson is likely to be accompanied by additional light states generated by the same dynamics. This expectation is substantiated when realizing the composite Higgs mechanism by an underlying gauge theory. We review the dynamics of such objects, which may well be the first sign of compositeness at colliders. We also update our previous analysis of the bounds from LHC searches to the
Background: The aim of this study was to identify predictors of outcome after septoplasty in 888 patients from the Swedish National Septoplasty Register. Methodology: This is an observational register study analysing data from patients undergoing septoplasty in Sweden between 2015 and 2016. The patients reported severity of nasal obstruction (mild, moderate, severe) pre- and again 12 months postop
Objective: In patients with myocardial infarction (MI), risk factors for bleeding and ischaemic events tend to overlap, but the combined effects of these factors have scarcely been studied in contemporary real-world settings. We aimed to assess the combined associations of established risk factors using nationwide registries. Methods: Using the Swedish Web-system for Enhancement and Development of
Following Emily Wardill's exhibition "Matt Black and Rat" at Bergen Kunsthall, January 20th to March 26th 2017, the publication Things Keep Their Secrets, is an extensive and multi-faceted work which includes both images and stills from the artist's latest works, the unique fumages, manually inserted into each of the 750 copies – as well as two newly commissioned texts by philosopher Michael Marde
- Field data on breeding phenology of Ranaarvalis and R.temporaria for the period 1990- 2017 in Scania, Sweden are presented and analysed. There was no temporal trend for R.temporaria. ForR.arvalisthe results were mixed, one out of two approaches found a trend to earlier breeding. The lack of a consistent trend in breeding phenology is unsurprising considering that local mean air temperatures in F
Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Swe
Lakes are a key feature of arctic landscapes and can be an important component of regional organic carbon (OC) budgets, but C burial rates are not well estimated. 210 Pb-dated sediment cores and carbon and organic matter (as lo
One of the central assumptions of modernity is that the problems faced by society are best resolved through the use of scientific knowledge. Indeed, during the past century, the professions have both become certified and expected to base their work on this form of knowledge. In contemporary social work, this assumption is embedded in the notion of evidence-based practice, which has become the leadOne of the central assumptions of modernity is that the problems faced by society are best resolved through the use of scientific knowledge. Indeed, during the past century, the professions have both become certified and expected to base their work on this form of knowledge. In contemporary social work, this assumption is embedded in the notion of evidence-based practice, which has become the lead
Objective: A liquid mepolizumab formulation in a single-use prefilled syringe (PFS) is under development. We evaluated the usability of mepolizumab self-injected via PFS by patients with severe eosinophilic asthma (SEA), or their caregivers, in clinic and at home. Methods: This open-label, single-arm, Phase IIIa study included patients with SEA, aged ≥12 years, and receiving mepolizumab (100 mg su
The lipolysis of rat chylomicron polyenoic fatty acid esters with bovine milk lipoprotein lipase and human hepatic lipase was examined in vitro. Chylomicrons obtained after feeding fish oil or soy bean oil emulsions were used as substrates. The lipolysis was followed by gas chromatography or by using chylomicrons containing radioactive fatty acids. Lipoprotein lipase hydrolyzed eicosapentaenoic (2
[3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wa[3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wa
Although intimate partner violence is far from a new problem in society, it has lately gained increased attention both by governments and by the research community. In 2007, the Swedish government issued an action plan for “combating men’s violence against women, violence and oppression in the name of honour and violence in same-sex relationships” (2007/08:39), which included a call for increased
The mechanism by which an apparently uniform population of cells can generate a heterogeneous population of differentiated derivatives is a fundamental aspect of pluripotent and multipotent stem cell behaviour. One possibility is that the environment and the differentiation cues to which the cells are exposed are not uniform. An alternative, but not mutually exclusive possibility is that the obser
