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Glucuronidation is the major phase II biotransformation reaction that facilitates the clearance of exogenous compounds from the human body. Glucuronidated metabolites have been investigated in urine samples at a broad scale; however, their characterization in other human biospecimens is underexplored. Our study has now performed a comprehensive profiling of glucuronides in plasma, fecal, and cereb

Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an

We report the fabrication of three-dimensional topological insulator heterostructures using a single-step bottom-up approach based on directional solidification. These materials exhibit atomically smooth interfaces, preserving topological surface states and enabling hetero-junction formation. This scalable approach paves the way for advancements in spintronics, quantum computing, and novel optoele

Meta-analyses are vital for synthesizing evidence in medical research, but conflicts of interest can introduce research bias, undermining the reliability of the synthesized findings. This paper proposes a new robust Bayesian meta-analysis model. The model inflates uncertainty of low-quality studies and incorporates a bias term for studies subject to conflicts of interest. Using a random-effects mo

The Canary Islands are an island chain created by volcanic activity, despite extensive studies of the region there is not a clear consensus of their process of creation, primarily there is a question concerning the origin of the magmas which has built up this chain of islands. The largest contributor to these uncertainties is the continued volcanic activity on older islands, something which does n

Aims: Spontaneous coronary artery dissection (SCAD), causing acute coronary syndrome (ACS), primarily in middle-aged women, is diagnosed with invasive coronary angiography (ICA). Due to the risk of dissection propagation with ICA, a non-invasive diagnostic tool is needed. We investigated coronary computed tomography angiography (CCTA) findings in acute SCAD, as well as the inter-modality agreement

Al-Hoorie, Hiver, and In'nami (2024) offer compelling arguments for why L2 motivational self-system research is currently in a state of validation crisis. Seeking a constructive resolution to the crisis, in this response we argue that two fundamental conditions are needed for the field to emerge stronger: psychological readiness and methodological maturity. For psychological readiness, we call for

Understanding 3D human interactions is fundamental for fine-grained scene analysis and behavioural modeling. However, most of the existing models predict incorrect, lifeless 3D estimates, that miss the subtle human contact aspects–the essence of the event–and are of little use for detailed behavioral understanding. This paper addresses such issues with several contributions: (1) we introduce model

Introduction: Myocarditis is a complex cardiac disorder with multifactorial etiology, characterized by myocardial inflammation, cardiomyocyte damage, and fibrosis. Left untreated, myocarditis may lead to acute and chronic heart failure and life-threatening arrhythmias. Reliable experimental models of myocarditis are required to study the underlying pathological mechanisms of the disease and to dev

How may changes in musicians’ experience of time influence their impressions of hav- ing conscious intentions during musical activity? In this essay I will present and discuss an autoethnographic account of how an exceptionally heightened awareness of time during musical improvisation may be connected to a heightened awareness of one’s own mental activity, particularly of speedy internal deliberat

We consider the averaging process on an infinite connected graph with bounded degree and independent, identically distributed starting values or initial opinions. Assuming that the law of the initial opinion of a vertex has a finite second moment, we show that the opinions of all vertices converge in L2 to the first moment of the law of the initial opinions. A key tool in the proof is the Sharing

We study mixed-integer optimal control problem using indirect approaches. The proposed method relies on splitting algorithms which separate the mixed problem into two solvable pieces and then iteratively alternating between the two. The algorithm gives approximated local solutions, and provides lower and upper bounds estimations of the global optimum. Simulations are provided to validate our appro

Purpose: Cardiac diffusion tensor imaging (cDTI) can investigate the microstructure of heart tissue. At sufficiently high b-values, additional information on microstructure can be observed, but the data require a representation such as diffusion kurtosis imaging (DKI). cDTI is prone to image corruption, which is usually treated with shot rejection but which can be handled more generally with robus

Integrating in-situ (wild) and ex-situ (captive) conservation efforts can mitigate genetic diversity loss and help prevent extinction of endangered wild populations. The whooping crane (Grus americana) experienced severe population declines in the 18th century, culminating in a collapse to ~20 individuals by 1944. Legal protections and conservation actions have since increased the census populatio

Purpose: We aimed to investigate the association between overlapping threat to fixation (TTF) and vision-related quality of life (VRQoL) in patients with manifest open-angle glaucoma (OAG). Methods: Overall, 316 patients with manifest OAG were recruited from the glaucoma outpatient department of Skåne University Hospital, Malmö, Sweden, between April and December 2018. VRQoL was assessed using the

The Swedish province of Västergötland is home to around 180 churches from the Middle Ages and played an important role in the processes of Christianisation and subsequent state-building of Sweden. The roof structures of these churches act as a window to our past where we can learn information on construction dates and techniques as well as the use of local resources, such as timber. In this joint