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Abdominal adhesions - clinical impact and experimental prevention

Popular Abstract in Swedish Sammanväxningar i buken är en normal reaktion efter skador i bukhinnan och utvecklas efter ett inflammatoriskt svar och det efterföljande läkningsförloppet. Många sammanväxningar bildas inom 24-48 timmar efter skadan och tillbakabildas normalt efter 5-7 dagar. Många av de sammanväxningar som kvarstår kan ses som en obalans i de system som bildar ärr (fibros) och löser dIntraabdominal adhesions are formed after most operations and a limited number of studies have to examine the long-term spectrum of adhesion-related disorders and the cost associated with this. Only a few numbers of antiadhesive agents are available which, however, do not decrease the actual morbidity that follows intraabdominal adhesions, such as small bowel obstruction, infertility and pain. Fut

DNA based classification of food associated Enterobacteriaceae previously identified by biolog GN microplates

Enterobacteriaceae are frequently isolated from food products and it is essential to have methods for correct identification for both food hygiene and epidemiology reasons. Phenotypic methods are not always sufficient and have to be supplemented by DNA based methods. In the present study, 70 strains of Enterobacteriaceae derived from milk, fish and meat that had previously been identified by Biolo

Compact medical fluorosensor for minimally invasive tissue characterization

A compact fiber-optic point-measuring fluorosensor fully adapted to clinical studies is described. The system can use two excitation wavelengths, 337 and 405 nm, obtained from a nitrogen laser directly, or after dye laser conversion, respectively. The image intensifier used in the spectrometer can be gated with a variable time delay, allowing also time-resolved spectra to be extracted, with a time

Obesity and cardiovascular disease. Aspects of methods and susceptibility.

Popular Abstract in Swedish Fetma räknas som ett av världens tio viktigaste hälsoproblem enligt WHO och ökar i snabb takt. Man beräknar att över 1 miljard av världens vuxna befolkning är överviktig, d.v.s. har ett kroppsmasseindex (BMI) ?25.0 kg/m², varav 300 miljoner är feta, d.v.s. har ett BMI ?30.0 kg/m². I Sverige är 38% av kvinnor och 58% av män mellan 25 och 64 år överviktiga, och 11% respekThe aim of this thesis was to study the morbidity and mortality of cardiovascular disease (CVD) in obese individuals, as measured by different obesity measurements, and to explore how the CVD risk related to obesity was modified by other biologic and socio-demographic circumstances. Data from two population-based cohort studies was used. The Malmö Preventive Project included 22 444 middle-aged me

A Case Study Investigating the Characteristics of Verification and Validation Activities in the Software Development Process

System verification and validation are important activitiesin the software development process aiming at testing thesoftware system in various quality aspects.The purpose of this study is to investigate theimportant characteristics of the verification andvalidation activities in the software development processin an organization. A qualitative research method isemployed in order to facilitate the

Full oscillation cycle phase noise analysis of differential CMOS LC oscillators

This paper analyzes the phase noise of the widely used differential LC oscillator topology and presents brief equations describing phase noise over the entire oscillation period. The findings show that if a capacitance is present at the source node of the differential pair, two phenomena occur that increase the phase noise: the switch time increases, lengthening the interval spent in a noisy balan

Deconvolution under monotonicity assumptions

We state limit distribution results for the isotonic inverse estimator of a distribution function when the data are disturbed by a random variable with a decreasing density. Three different dependence structures are considered: independent, weak dependent and suboordinated gaussian long range dependent data.

Natural history of patients with unoperated atherosclerotic carotid artery disease--results from a retrospective study

The natural history of carotid artery disease was studied in a retrospective study of 609 angiograms performed during 1969-1979 on patients who had subsequently not been operated on. The indication for angiography differed, but was aimed at clarifying suspected cerebrovascular events. 578 patients could be followed-up after a median time of 10.4 years (0-22). The median survival time after angiogr

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.

Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation of platelet-derived growth factor-B gen

SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening

We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contrala

Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists

Background: Existing studies of solid cancers in rheumatoid arthritis ( RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s. Objective: To depict the cancer pattern of contemporary patients with RA, from updated risk data from prevalent and incident RA populations. To understand the risk of solid cancer after tumour necrosis factor (TNF)

Achalasia: A vagal disease

Background: Achalasia is considered to be a primary motor disorder of the oesophagus. However, there is increasing evidence to suggest extra- oesophageal involvement in this disease. Vagal disturbances at different levels and extra- oesophageal dysmotility have been reported in several studies. The aim of this study was to examine cardiovascular reflexes in patients with achalasia further to evalu

Hip fractures in Hungary and Sweden - differences in treatment and rehabilitation

Data of 1,337 consecutive hip fracture patients were registered during I year within a prospective comparative multicenter study comparing osteosynthesis techniques and rehabilitation results in Budapest, Hungary, in Sundsvall, northern Sweden, and in Lund, southern Sweden. In Budapest the mean age was 4-5 years lower than in Sweden, and more patients lived in their own home (91% versus 70% and 62

Vesicle formation from temperature jumps in a nonionic surfactant system

When heating a dilute sample of the binary system of tetraethyleneglycol dodecyl ether (C12E4) and water from the micellar phase (L-1) into the two-phase region of a lamellar phase (L-alpha) and excess water (W) vesicles are formed. During heating, one passes a region of phase separation in the micellar phase (L-1' + L-1") where the initial micelles rapidly fuse into larger aggregates forming the

Inhibitory properties of cystatin F and its localization in U937 promonocyte cells

Cystatin F is a recently discovered type II cystatin expressed almost exclusively in immune cells. It is present intracellularly in lysosome-like vesicles, which suggests a potential role in regulating papain-like cathepsins involved in antigen presentation. Therefore, interactions of cystatin F with several of its potential targets, cathepsins F, K, V, S, H, X and C, were studied in vitro. Cystat