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Frequency dispersed transient absorption spectra of dissolved perylene: A case study using the density matrix version of the MCTDH method

A theoretical scheme is presented to calculate non-linear optical spectra of molecules in solution. Starting with electronic structure calculations of the ground and excited state, a subset of vibrational coordinates exhibiting the largest Huang-Rhys factors is assigned. It is used to set up a model Hamiltonian for density matrix multi configurational time-dependent Hartree (MCTDH) calculations. T

A two-week monitoring of self-reported arousal, worry and attribution among persons with annoyance attributed to electrical equipment and smells.

Non-patients attributing annoyance to either smells (smell annoyed; SA, n= 29) or electrical equipment (electrically annoyed; EA, n= 17), or both (generally annoyed; GA, n= 38), were monitored for 2 weeks through daily self-ratings of arousal (stress), sleep disturbances, health complaints, worry about hypersensitivity reactions, avoidance behaviors, and attributions of health complaints to electr

Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer.

Alterations in cellular pathways related to both endocrine and vascular endothelial growth factors (VEGF) may contribute to breast cancer progression. Inhibition of the elevated levels of these pathways is associated with clinical benefits. However, molecular mechanisms by which endocrine-related pathways and VEGF signalling cooperatively promote breast cancer progression remain poorly understood.

Combined optical porosimetry and gas absorption spectroscopy in gas-filled porous media using diode-laser-based frequency domain photon migration

A combination method of frequency domain photon migration (FDPM) and gas in scattering media absorption spectroscopy (GASMAS) is used for assessment of the mean optical path length (MOPL) and the gas absorption in gas-filled porous media, respectively. Polystyrene (PS) foams, with extremely high physical porosity, are utilized as sample materials for proof-of-principle demonstration. The optical p

Topology optimization utilizing inverse motion based form finding

Topology optimization at finite strain setting using the concept of inverse motion based form finding is introduced. This novel procedure allows boundary conditions and shape of the structure in the operating, deformed, state to be prescribed. The outcome of the optimization algorithm will be the shape of the undeformed structure, i.e. the state in which the structure should be manufactured. The o

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

OBJECTIVE-Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as

Evaluating the accuracy and precision of a two-compartment Kärger model using Monte Carlo simulations.

Specific parameters of the neuronal tissue microstructure, such as axonal diameters, membrane permeability and intracellular water fractions are assessable using diffusion MRI. These parameters are commonly estimated using analytical models, which may introduce bias in the estimated parameters due to the approximations made when deriving the models. As an alternative to using analytical models, a

The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children

Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one inc

Improving student success in difficult engineering education courses through Supplemental Instruction (SI) – what is the impact of the degree of SI attendance?

The customary way to determine whether an adopted Supplemental Instruction (SI) program has been successful or not is by comparing course results for two groups, SI attendees and non-attendees. The division of SI attendees and non-attendees is generally done rather arbitrarily by prescribing a minimum number of SI sessions a student has to attend to be considered an SI attendee. Although the SI at

Quantification of mRNA in single cells and modelling of RT-qPCR induced noise

Background: Gene expression has a strong stochastic element resulting in highly variable mRNA levels between individual cells, even in a seemingly homogeneous cell population. Access to fundamental information about cellular mechanisms, such as correlated gene expression, motivates measurements of multiple genes in individual cells. Quantitative reverse transcription PCR ( RT-qPCR) is the most acc

Interactions between Predation and Resources Shape Zooplankton Population Dynamics.

Identifying the relative importance of predation and resources in population dynamics has a long tradition in ecology, while interactions between them have been studied less intensively. In order to disentangle the effects of predation by juvenile fish, algal resource availability and their interactive effects on zooplankton population dynamics, we conducted an enclosure experiment where zooplankt

Follow-up of Adolescents Born Extremely Preterm Cognitive Function and Health at 18 Years of Age.

Abstract Aim: To compare cognitive ability, school achievement and self-perceived health aspects in adolescents born extremely preterm and term born controls. Method: Fifty-two, out of 61, extremely preterm born adolescents (mean age 18.4 years) and 54 matched controls (mean age 18.3 years) born at full term were investigated; intelligence quotient was measured with the Wechsler Adult Intelligence

Iso-luminance counterillumination drove bioluminescent shark radiation.

Counterilluminating animals use ventral photogenic organs (photophores) to mimic the residual downwelling light and cloak their silhouette from upward-looking predators. To cope with variable conditions of pelagic light environments they typically adjust their luminescence intensity. Here, we found evidence that bioluminescent sharks instead emit a constant light output and move up and down in the

Jets in QCD media: From color coherence to decoherence

We investigate soft gluon radiation off a quark-antiquark antenna in both color singlet and octet configurations traversing a dense medium. We demonstrate that, in both cases, multiple scatterings lead to a gradual decoherence of the antenna radiation as a function of the medium density. In particular, in the limit of a completely opaque medium, total decoherence is obtained, i.e., the quark and t

Gender, Buddhism and Social Resilience in the Aftermath of the Tsunami in Thailand.

Abstract in UndeterminedThis paper addresses the recovery in Thailand after the 2004 Indian Ocean tsunami. The country worst affected by the tsunami was Indonesia, while in Thailand about 8,000 people were assumed dead. In all the countries affected more females were killed than males. Disasters test the strength of a society's structures and relationships, and this paper focuses on the interplay

Local environmental governance: Assessing proactive initiatives in building energy efficiency

Popular Abstract in Swedish Städer har kommit att framstå som alltmer drivande i arbetet med att ställa om till ett ekologiskt hållbart samhälle. Utöver att genomföra statliga direktiv eller fokusera på klassiskt kommunala uppgifter som fysisk planering eller renhållning, har kommunala politiker och tjänstemän alltmer kommit att driva en egen miljöpolitik på lokal nivå. Ett exempel är energi- och Local governments are increasingly taking the initiative in environmental governance. But can they make any difference in addressing current environmental challenges, which are becoming more and more global in scope? This PhD thesis explores and analyses the outcomes of proactive initiatives in the field of building energy efficiency, and the governance approaches taken. It addresses outcomes both

Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway

Background: Subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. It is suggested that the associated inflammation is mediated through activation of the mitogen-activated protein kinase (MAPK) pathway which plays a crucial role in the pathogenesis of delayed cerebral ischemia after SAH. The aim of this study was first to investigate the timecourse of altered expression of

Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study

The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs with Pgp activity and exposure to different immunosuppressive drugs in renal transp