Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European

Background. The acronym ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) highlights that children seeking clinical treatment are often multiply impaired, thus requiring treatment from several specialties. The aim was to map and relate, on a population level, ESSENCE to two salient predictors of health and adaptation to adversities, namely, Self-Directedness

Popular Abstract in Swedish Dercums sjukdom är ovanlig sjukdom som kännetecknas av uttalad kronisk smärta (>3 månader) i fettväven, kombinerad med övervikt och ett antal mer diffusa associerade symptom, såsom trötthet och allmän sjukdomskänsla. Orsaken till sjukdomen är okänd. Smärtorna är ofta handikappande och de flesta prövade behandlingar, såsom traditionella smärtstillande, ger otillräcklig eDercum’s disease is a rare condition characterised by obesity, chronic pain (>3 months) in the adipose tissue and a number of diffuse associated symptoms, such as fatigue and malaise. The aetiology of the disease is unknown. The experienced pains are often disabling and resistant to most tried treatments, such as analgesics. However, a number of case reports have been published on the promising ef

Background. Patient information in cancer clinical trial is challenging. The value of audio-recording interventions for patients considering participating in clinical trials is unclear. The primary aim of this randomized study was to investigate effects of audio-recorded information on knowledge and understanding in patients considering participation in a clinical trial. Material and methods. Pati

The recent financial crisis starting in 2007-2009 is the longest and the deepest recession since the Great Depression of 1930. The crisis that originated in the US subprime mortgage markets spread and amplified through international financial markets and resulted in severe debt crises in several European countries. Events revealed that the European Union (EU) had insufficient means to halt the spi

Aim To investigate how the chemical composition of native organic matter of two contrasting soils varies with inputs of biochar and fresh material (including plant roots) and how these underlying changes influence microbial community structure. Methods Corn stover (CS) and CS-derived biochars produced at 350 °C and 550 °C were applied at a dose of 7.2 t C ha−1 to two contrasting soils—an Alfis

ColorFull, a C++ package for treating QCD color structure, is presented. ColorFull, which utilizes the trace basis approach, is intended for interfacing with event generators, but can also be used as a stand-alone package for squaring QCD amplitudes, calculating interferences, and describing the effect of gluon emission and gluon exchange.

Background: It has been well documented that apolipoprotein M (apoM) is principally expressed in the liver and kidney. However we found that there was weak apoM expression in other tissues or organs too, which could not be ignored. In the present study, we therefore examined apoM expression in human colorectal tissues including cancer tissues, cancer adjacent normal tissues, polyp tissues and norm

A thermomechanically coupled constitutive model for finite strain elasto-plasticity is formulated and numerically implemented. The model gives a physically sound description of an initially austenitic material influenced by martensitic phase transformation. The heat dissipated by plastic slip deformation and by phase transformation is allowed to influence the material behavior and appears as a key

Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were ide

The maximum light use efficiency (LUE = gross primary production (GPP)/absorbed photosynthetic photon flux density (aPPFD)) of plant canopies has been reported to vary spatially and some of this variation has previously been attributed to plant species differences. The canopy nitrogen concentration [N] can potentially explain some of this spatial variation. However, the current paradigm of the N-e

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Using exome sequencing and a variant prioritization strategy that focuses on loss-of-function variants, we identified biallelic, loss-of-function CEP57 mutations as a cause of constitutional mosaic aneuploidies. CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining

microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the brain. It has also been shown that alterations in levels of specific miRNAs have implications in var

MicroRNAs (miRNA) are small, non-coding RNAs mediating post-transcriptional regulation of gene expression. miRNAs have recently been implicated in hippocampus-dependent functions such as learning and memory, although the roles of individual miRNAs in these processes remain largely unknown. Here, we achieved stable inhibition using AAV-delivered miRNA sponges of individual, highly expressed and bra