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Radioimmunotherapy (RIT) is a therapeutic strategy in which radionuclides are conjugated to monoclonal antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to investigate the effects of RIT (utilizing the radioconjugated antibody 177Lu-BR96) on an inoculated tumor and
OBJECTIVE: To assess the outcome of vacuum-assisted wound closure (VAC(®)) therapy for infected bypass grafts. METHODS: A retrospective 7-year review of patient records from 2004 to 2011 of all patients receiving VAC(®) therapy for infected bypass grafts. RESULTS: Thirty-seven patients with 42 wounds and 45 infected bypass (28 synthetic) grafts received VAC(®) treatment. Two serious bleeding e
In a rabbit model, we have previously reported evidence for a pathogenic role of streptococcal IgG Fc-binding proteins (IgGFcBP) in poststreptococcal glomerulonephritis (PSGN). These proteins, of the M protein family, were shown to trigger anti-IgG production and enhance renal deposition of IgG and/or immune complexes (ICs), with resulting activation of complement and cytokine cascades. In the pre
During the last 35 years almost 5000 ceramic thin-sections have been analysed at the Laboratory for Ceramic Research, Lund University and of those have 1650 analyses been performed on material from the Iron Age in Northern Europe (here c. 500 BC-1100 AD). Currently there is a project to register these analyses in a database and evaluate the results. We can for the first time get an overall picture
While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for
Historically, organizations developed their information systems in-house. Today, a large portion of information systems development is based on the acquisition of pre-made information systems, so-called commercially off-the-shelf (COTS) systems. This approach for developing information systems requires new skills and methods supporting the process of evaluating and selecting information systems. T
Over the last years an expanding family of small non-coding RNAs (sRNA) has been identified in eukaryotic genomes which behave as sequence-specific triggers for mRNA degradation, translation repression, heterochromatin formation and genome stability. To achieve their effectors functions, sRNAs associate with members of the Argonaute protein family. Argonaute proteins are segregated into three para
Kulturpristagare 1992 Kerstin Wallin journalist Erland Forsberg ikonmålare + Kulturpristagare 1993 Henrik Cervin domkyrkoorganist Gunnar Kampe kyrkoherde + Kulturpristagare 1994 Lars Hernqvist kyrkomusiker Jerker Leijon kyrkomusiker Ann-Marie Rydberg kyrkomusiker + Kulturpristagare 1995 Ingvar Rohr kyrkklocksexpert + Kulturpristagare 1996 Christina Löwestam bön- och sångdiktare Thomas Simson sport
Background: Airborne particles are associated with increased morbidity and mortality due to respiratory and cardiovascular diseases in polluted areas. There is a growing interest in nano-sized particles with diameter < 100 nm and their potential health effects. Heart rate variability (HRV) is a noninvasive method for cardiovascular risk prediction in high prevalent groups. Aim of study: The aim wa
Brottsoffer är ett ord med många konnotationer som har kritiserats för att antyda hjälplöshet och passivitet. Att kategoriseras som brottsoffer är inte alltid välkommet, men medför likväl fördelar, som till exempel möjligheten att driva en rättsprocess och tillgång till stöd och empati. I Sverige är Riksorganisationen Brottsofferjouren Sverige (BOJ) en viktig aktör när det gäller att ge brottsoffeCrime victim is a term with many connotations, which has been criticized for implying passivity and helplessness. To be categorized as a crime victim is not always welcomed. Still, being able to claim status as a victim is also connected to gains, in terms of both financial compensation and emotional support and compassion. In Sweden, Victim Support Sweden is an important actor in supplying help a
Recent experimental progress in coupling nanoscale conductors to superconducting microwave cavities has opened up for transport investigations of the deep quantum limit of light-matter interactions, with tunneling electrons strongly coupled to individual cavity photons. We have investigated theoretically the most basic cavity-conductor system with strong, single photon induced nonlocal transport e
Calmodulin (CaM) is the central mediator of intracellular Ca2+ signalling in cardiomyocytes, where it conveys the intricate Ca2+ transients to the proteins controlling cardiac contraction. We recently linked two separate mutations in CaM (N53I and N97S) to dominantly inherited catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmic disorder in which exercise or acute emotion ca
A Summary In a large cohort of elderly women followed for 10 years, we found that balance, gait speed, and self-reported history of fall independently predicted fracture. These clinical risk factors are easily evaluated and therefore advantageous in a clinical setting. They would improve fracture risk assessment and thereby also fracture prevention. Introduction The aim of this study was to identi
Objectives: To study: (I) work-loss seen as sick leave and disability pension before and after the start of first anti-TNF therapy in Swedish regional and national RA cohorts; (II) baseline predictors of a good future work prognosis at diagnosis and after anti-TNF start with a special focus on the impact of the disease activity level and the disease duration at treatment start. Methods: RA patien
