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Objective: To quantify opioid use in knee and hip osteoarthritis (OA) patients, and to estimate the proportion of opioids in the population attributable to OA patients. Design: Population-based cohort study. Methods: We included 751,579 residents in southern Sweden, aged ≥35 years in 2015. Doctor-diagnosed knee or hip OA between 1998 and 2015 was the exposure. Dispensed weak and strong opioids wer

Systemic lupus erythematosus (SLE, OMIM 152700) is a systemic autoimmune disease with a complex etiology. The mode of inheritance of the genetic risk beyond familial SLE cases is currently unknown. Additionally, the contribution of heterozygous variants in genes known to cause monogenic SLE is not fully understood. Whole-genome sequencing of DNA samples from 71 Swedish patients with SLE and their

Ur ett strukturcykliskt perspektiv sker en omvandling av ekonomi, institutioner och politik under omvandlingsperioderna. Då välfärd kan betraktas som en funktion av dessa borde det vara möjligt att analysera välfärd och de institutionella arrangemang som är nödvändiga för en välfärdsproduktion med hjälp av en strukturcyklisk ansats. Lennart Schön har i ett flertal studier diskuterat detta samband,

Introduction: Infiltration of T and B/plasma cells has been linked to NSCLC prognosis, but this has not been thoroughly investigated in relation to the expression of programmed death ligand 1 (PD-L1). Here, we determine the association of lymphocytes and PD-L1 with overall survival (OS) in two retrospective cohorts of operated NSCLC patients who were not treated with checkpoint inhibitors targetin

Bullshit is a ubiquitous communication practice that permeates many dimensions of organizational life. This essay outlines different understandings of bullshit and discusses their significance in the context of organization studies. While it is tempting to reject bullshit as corrosive to rational organizational practice, we argue that it is necessary to understand its organizational significance a

e summarize our successful efforts to support in-tuitive programming of industrial robotic assemblytasks with a knowledge based approach to the rep-resentation of skills. These skills can be specified,re-used, refined and transferred between robotswith the help of a multimodal interface combinedwith kinesthetic teaching. We argue that while itis certainly possible and suitable to have robotsacquir

A γ-decaying isomeric state (τ1/2=197+19−17 ns) has been identified in 96Cd, which is one α particle away from the last known bound N=Z nucleus, 100Sn. Comparison of the results with shell-model calculations has allowed a tentative experimental level scheme to be deduced and the isomer to be interpreted as a medium-spin negative-parity spin trap based on the coupling of isoscalar (T=0) and isovect

Background & Aims: Evidence on the association between physical activity and risk of hepatobiliary cancers is inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cance

There is widespread consensus that teamwork constitutes one of the key requirements in today’s multidisciplinary and highly complex system of delivering care. In recent years, increasing attention has been given to questions of how to define, teach, measure, and improve teamwork in healthcare. However, one cannot help but feel a certain disconnect between this ongoing trend in healthcare with an a

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy — dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) — have overlapping clinical and pathologica

Objective: To investigate health-related quality of life (HrQoL) and adaptive behavior in young people with narcolepsy and stress among their parents. Methods: In a cross-sectional exploratory quantitative study design, 37 young people with narcolepsy (8–20 years of age) and their parents were recruited. Thirty-one had post-H1N1 vaccination-related narcolepsy (PHV) and six had narcolepsy not relat

Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognosis of many cancers, few studies examined DNA methylation in EGLNs and its relationship to prognosis