Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis

The influence on the short-range packing in dipolar fluids by molecular shape and by additional higher order electrostatic moments has been investigated by molecular dynamic simulations. The dipole polarization was found to decrease as the particles were elongated parallel to the dipole and to increase for elongation perpendicular to the dipole, eventually forming a nematic order. The addition of

The aim of the study was to estimate the prevalence of prediabetes and type 2 diabetes (T2D) among overweight/obese children and adolescents using different diagnostic/screening methods in comparison.

This paper focuses on the nexus between nascent entrepreneurship (NE) and inventive activity. It questions how NE affects inventive activity (including innovation and patenting) while analyzing the views and predictions that have used patenting as an indicator of entrepreneurial behavior. Using data on German researchers and controlling for their personal, professional and institutional attributes

Software failures in medical devices can lead to catastrophic situations. Therefore, it is crucial to handle software-related risks when developing medical devices, and there is a need for further analysis of how this type of risk management should be conducted. The objective of this paper is to collect and summarise experiences from conducting risk management with an organisation developing medic

Background: Osteoporosis is increasingly recognised as one of the major public health problems throughout the world and has massive socioeconomic implications. It has previously been shown that patients with severe haemophilia and not receiving any prophylactic treatment render a high risk of reduced bone density. Aims: To evaluate Bone Mineral Density (BMD) in patients with haemophilia of differ

The article takes issue with how theology should and could investigate religious doctrines and praxis. It argues that traditional metaphysical accounts often found in theology are scientifically inept to explain the human cause and function of religious dogma. Arguing from pragmatism the article tries to delineate a framework within which theology could circumvent the troublesome metaphysics that

Requirements communication plays a vital role in development projects in coordinating the customers, the business roles and the software engineers. Communication gaps represent a significant source of project failures and overruns. For example, misunderstood or uncommunicated requirements can lead to software that does not meet the customers’ requirements, and subsequent low number of sales or add

The structures of two polymorphs, one triclinic and one monoclinic, of cis-dichlorobis(dibenzyl sulfido-kS)platinum(II), cis-PtCl2(Bz2S)2 have been determined at 295, 250, 200, 150 and 100 K. In both polymorphs the complex has a structure where platinum(II) coordinates two dibenzyl sulfide molecules and two chloro ligands, forming a complex with pseudo-sqare-planar coordination geometry. The tricl

Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in the general population. It is defined as a serum IgA level below or equal to 0.07 g/l with normal IgM and IgG levels in children over the age of 4. However, a few cases of reversal of IgAD at later ages have been observed previously, especially in pediatric patients. This study aimed at investigating the frequency of

Popular Abstract in Swedish Kardiovaskulär sjukdom är ett samlingsnamn för sjukdomar som involverar hjärtat och/eller kärlen. De är orsaken till 41 % av alla dödsfall i Sverige, och 12 % av alla svenskar lider av följderna av dessa sjukdomar. Ateroskleros, som är en kardiovaskulär sjukdom, kan upptäckas redan hos barn. Då ser man ateroskleros som en förändring i kärlväggen (plack) och i detta stadAtherosclerosis is triggered by LDL entrapment in the vessel wall. Oxidation and enzymatic processing of LDL give rise to inflammatory mediators such as lyso-PC. These inflammatory mediators attract monocytes into the vessel wall where they differentiate into macrophages. The macrophages adopt different phenotypes depending on the environment. In vitro, ex vivo, and in vivo studies were combined

A common application of nanometer-sized gold particles is as seed particles for growth of semiconductor nanowires, which are believed to act as highly promising building blocks in future electronic devices. In a majority of the reports of successful nanowire growth, gold has been the seed particle material of choice. In this review article we identify the different types of gold particles used to

The major histocompatibility class I (MHC-I) genes are highly polymorphic and the proteins that they encode play a crucial role in both the innate and the adaptive immune response. A MHC-I molecule consists of three parts, one polymorphic heavy chain, one invariant light chain, β2-microglobulin and a peptide of usually between 8-11 amino acids in length. The maturation and quality control of MHC-I

This article is concerned with the linkages between events occurring at the macro-level and psychological phenomena. In particular it seeks to elaborate on the possible effects of globalization, migration, and multiculturalism on groups' and individuals' subjective experiences of security. Special attention is given to the concept of dialogicality in the light of the challenges posed by an increas

There is a paucity of studies assessing changes in measures of human neurotransmission during stressful events, such as surgery. Thirty-five patients without any neurological disorders undergoing knee replacements with spinal bupivacaine anaesthesia and propofol sedation had cerebrospinal fluid (CSF) drawn from a spinal catheter before, three hours after and the morning after surgery. The CSF conc

ALICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LH

Objectives: To describe the contribution of highly processed foods to total diet, nutrient intakes and patterns among 27 redefined centres in the 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Single 24-hour dietary recalls were collected from 36 034 individuals (aged 35-74 years) using a standardized computerized interview programme