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Background and Purpose: Inhibition of the G-protein gated ACh-activated inward rectifier potassium current, IK,ACh may be an effective atrial selective treatment strategy for atrial fibrillation (AF). Therefore, the anti-arrhythmic and electrophysiological properties of a novel putatively potent and highly specific IK,ACh inhibitor, XAF-1407 (3-methyl-1-[5-phenyl-4-[4-(2-pyrrolidin-1-ylethoxymethy

Background: Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT. Methods and Materials: We reanalyzed samples originally collected as part of a

Radiation therapy is part of the standard of care for gliomas and kills a subset of tumor cells, while also altering the tumor microenvironment. Tumor cells with stem-like properties preferentially survive radiation and give rise to glioma recurrence. Various techniques for enriching and quantifying cells with stem-like properties have been used, including the fluorescence activated cell sorting (

To shed light on the interaction between macroprudential and monetary policies, we study the inward transmission of foreign monetary policy in conjunction with domestic macroprudential and monetary policies in Norway and Sweden. Using detailed bank-level data we show how Norwegian and Swedish banks’ lending reacts to monetary policy surprises arising abroad, controlling for the domestic macroprude

The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implemen

Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages. Patients and methods: The Nordic Anal Cancer

Unequal distribution of wealth is a matter of growing concern in contemporary society, but it is also one with deep roots in the past. Several authors have traced the origins of this inequality by reconstructing historical series and collecting and harmonising data from sources and records with uneven territorial and temporal cover (Milanovic et al. (2011), Alfani (2015) Piketty (2014 and 2020)).

Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urology met on February 21, 2020, in Amsterdam, The Netherlands, to formulate criteri

The pandemic of COVID-19 is a global challenge for health care, and dermatologists are not standing apart from trying to meet this challenge. The European Academy of Dermatology and Venereology (EADV) has collected recommendations from its Task Forces (TFs) related to COVID-19. The Journal of the EADV has established a COVID-19 Special Forum giving free access to related articles. The psychosocial

When Diffusion Tensor Imaging (DTI) is used in clinical studies, statistical hypothesis testing is the standard approach to establish significant differences between groups, such as patients and healthy controls. However, diffusion tensors contain six degrees of freedom, and the most commonly used univariate tests reduce them to a single scalar, such as Fractional Anisotropy. Multivariate tests th

In recent years, quantitative approaches based on mathematical theories and ICT tools, known under the terms of digital, computational, and virtual archaeology, are more and more involved in the traditional archaeological research. In this paper, we apply shape analysis techniques to 3D digital replicas of archaeological findings to support their interpretation. In particular, our study focuses on

This chapter explains the concept of human security at the international policy level, and reflects upon its narrower and broader meanings. It considers the potential ‘added value’ of the human security concept. Prolonged armed conflict jeopardizes the basic elements needed for human survival, including fundamental rights and freedoms. In order to bring an appreciable ‘added value’ to internationa

On the standard view, an agnostic might commit non-doxastically to religion because she wants to receive some goods, which might be either natural or supernatural in kind. I broaden the picture by showing how the agnostic must also take negative factors into account. Negative mundane factors should be avoided as far as possible by the agnostic, and in extreme cases, even at the price of giving up