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PURPOSE: To investigate the correlation of estrogen receptor (ER) gene polymorphism to dry eye syndrome in postmenopausal women. METHODS: Xba I and Pvu II polymorphism of ER gene were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 65 patients with dry eye syndrome and 73 with controls in postmenopausal women. RESULTS: There was a significant difference