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The TLR2 Antagonist Staphylococcal Superantigen-Like Protein 3 Acts as a Virulence Factor to Promote Bacterial Pathogenicity in vivo

Toll-like receptor (TLR) signaling is important in the initiation of immune responses and subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus. Many studies have demonstrated the importance of TLR2 in murine S. aureus infection. S. aureus evades

Quantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry

Mesenchymal stromal cells (MSC) are ideal candidates for cell therapies, due to their immune-regulatory and regenerative properties. We have previously reported that lung-derived MSC are tissue-resident cells with lung-specific properties compared to bone marrow-derived MSC. Assessing relevant molecular differences between lung-MSC and bone marrow-MSC is important, given that such differences may

Visual proteomics of the human pathogen Leptospira interrogans

Systems biology conceptualizes biological systems as dynamic networks of interacting elements, whereby functionally important properties are thought to emerge from the structure of such networks. Owing to the ubiquitous role of complexes of interacting proteins in biological systems, their subunit composition and temporal and spatial arrangement within the cell are of particular interest. 'Visual

Norms in Action: The Individual Student in the School Climate

The importance of school climate in schooling has been demonstrated consistently over the last 50 years. In this study, we investigate how individual student norms and opinions shape and affect school climate. Through the use of secondary survey data collected within two research projects at eight schools throughout Sweden in two different years, we demonstrate how individual student norms develop

Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study

Background: Nephrolithiasis (NL) is known to be associated with gout, although there are few comparative studies on risk and risk factors for NL in gout compared to population cohorts. In this cohort study we investigated: (1) overall incidence of NL in gout (cases) and general population controls; (2) risk and risk factors (common comorbidities and medications) for first-time NL in cases and cont

Major histocompatibility complex genes partly explain early survival in house sparrows

Environmental factors and genetic incompatibilities between parents have been suggested as important determinants for embryonic mortality and survival. The genetic set-up of the immune system, specifically the highly polymorphic major histocompatibility complex (MHC) may also influence individual resistance to infections. MHC proteins are important for an appropriate adaptive immune response and e

Reality TV Crime Programs

Crime reality television is a significant origin story in understanding reality entertainment. In the 1980s, crime reality television captured the public’s imagination with cold cases, ongoing criminal investigations, surveillance feeds, and live appeals to the public for information to catch criminals. Early crime reality television borrowed from other factual genres, including news reportage, cr

Brand new images? Implications of Instagram photography for place branding

The aim of this article is to develop an understanding of what happens when Instagram photography is used for branding a place. Questions raised are which photographs are taken and published, does the practice result in novel ways of representing a place, and, in turn the image of a place. A practice approach to photography is used where focus is directed to the performative aspect of photography.

Mode i sju akter

Galleri 5 på Kulturhuset Stadsteatern. "Mode i sju akter presenterar arbeten av studenter från ett antal tongivande stockholmsbaserade utbildningar med fokus på mode, hantverk och textil. Funderar kring ekonomi, stil och modets förgänglighet gör Modedoktorn." http://kulturhusetstadsteatern.se/KonstDesign/Evenemang/2016/Mode-i-sju-akter/

Den kvantifierade konsumenten: Om behovet av tillit och transparens på datadrivna marknader

I kärnan av den digitala ekonomin finns idag användning av individrelaterad information, ofta reglerad i termer av personuppgifter. Som konsument är det dessvärre allt svårare att bedöma när den samlas in, hur den används och vilka aktörer som hanterar den över tid, vilket riskerar att undergräva den tillit som ofta är en förutsättning för en fungerade digital marknad. Denna policy brief använder