Reduction of Nystagmus as a Predictor of Efficacy of Motion Sickness Remedies
The effects of transdermally administered scopolamine (TTS-scopolamine, release rate 5 g/h) and dimenhydrinate (100 pmg) were examined on caloriC., angular acceleration induced and optokinetic nystagmus in 16 volunteers in a randomized doubleblind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus. In the rotatory test, two TTS-scopolamine and di