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X-linked hyper-IgM syndrome (X-HIM) is an immunodeficiency caused by mutations in the gene encoding the CD40 ligand (CD40L). A database (CD40Lbase) of CD40L mutations has now been established, and the resultant information, together with other mutations reported elsewhere in the literature, is presented here.
Two bitter stigmastane derivatives, vernoguinosterol (1) and vernoguinoside (2), have been isolated from the stem bark of Vernonia guineensis and their structures eludicated using spectroscopic methods. The new compounds exhibit trypanocidal activity.
Popular Abstract in Swedish Kvantdatorer har den unika egenskapen att de kan utföra samma beräkning för många olika startvärden samtidigt. Informationen i en vanlig dator är lagrad i ett minne som består av bitar, som kan ha värdena 1 eller 0. När ett program körs beror slutresultatet av startvärdena hos dessa bitar. Minnet i en kvantdator lagrar istället kvantbitar, som även de kan ha värdena 1 eThe main aim of this work, was to lay the foundations for the experimental realisation of a quantum mechanical controlled NOT gate in rare-earth-metal-ion-doped crystals. Small amounts of rare-earth elements, added during the growth of some inorganic crystals, will become substituted into the crystal lattice as trivalent ions. The trivalent rare-earth-metal ions between cerium, with atomic number
Abstract in French Nous avons étudié une nouvelle technique permettant d’analyser une feuille de papier encochée chargée en mode I, en se basant sur la modélisation cohésive des craquelures. La méthode prévoit la défaillance finale de la feuille, peu importe sa dimension ou la longueur initiale de la craquelure. Le commencement de la craquelure, le développement de la stabilité de la craquelure etA new approach to analyze notched paper sheet loaded in mode I, based on cohesive crack modelling, is investigated. The method predicts final failure of the sheet, regardless of the sheet size and initial crack length. Onset of crack growth, stable crack growth and onset of unstable crack growth are predicted. The simulations of the notched paper sheet reveal that the concept of autonomy, i.e. ind
BACKGROUND: A synthetic oxytocin analogue, barusiban, was shown to potently inhibit oxytocin-induced activity of myometrium from term pregnant women. The responsiveness to vasopressin was not influenced by the compound. OBJECTIVE: To test the effect of barusiban and a reference compound, atosiban, on oxytocin-induced activity of myometrium from women at preterm pregnancy in comparison to myometriu
Lipid rafts are microdomains of the plasma membrane which are enriched in glycosphingolipids and specific proteins. The reported interactions of several raft-associated proteins (such as, e.g., F3) with tenascin C and tenascin R prompted us to consider that these oligomeric multidomain glycoproteins of the extracellular matrix (ECM) could associate with rafts. Here, we show punctate immunocytochem
α-Galactosidase (EC 3.2.1.22) and β-mannosidase (EC 3.2.1.25) participate in the hydrolysis of complex plant saccharides such as galacto(gluco)mannans. Here we report on the cloning and characterization of genes encoding an α-galactosidase (AglC) and a β-mannosidase (MndA) from Aspergillus niger. The aglC and mndA genes code for 747 and 931 amino acids, respectively, including the eukaryotic signa
BACKGROUND: Rotational thromboelastography (ROTEG) has been proposed as a monitoring tool that can be used to monitor treatment of hemophilia with recombinant factor VIIa (rFVIIa). In these studies special non-standard reagents were used as activators of the coagulation. The aim of this study was to evaluate if standard ROTEG analysis could be used for monitoring of effects of recombinant factor V
Antithyroid treatment effectively restores euthyroidism in patients with Graves' hyperthyroidism. After a few months of treatment, patients are clinically euthyroid with normal levels of thyroid hormones, but in many patients TSH levels remain suppressed. We postulated that TSH receptor autoantibodies could directly suppress TSH secretion, independently from thyroid hormone levels, via binding to
Clinical trials involving intrastriatal transplants of human embryonic mesencephalic tissue have provided proof-of-principle that nigral dopamine (DA) neurons can survive and functionally integrate into the host neural circuitry. However, the degree of graft-induced symptomatic relief differs significantly between the patients. This variability has led to investigations aimed at identifying factor
Popular Abstract in Swedish Doften av blommor och mat förnimmer vi med näsan, vilken är en finurlig gassensor som även känner av mindre trevliga lukter från exempelvis rök och avgaser. Våra ögon ser färger och former hos föremål genom att detektera ljus som har reflekterats, brutits, spridits eller delvis absorberats i vår omgivning. Denna avhandling beskriver i någon mening en sorts konstgjorda Laser spectroscopic techniques for gas analysis under various influences of light scattering are explored in a wide spectral range from the ultraviolet to the infrared. The techniques rely on spectrally narrow-band light sources that are used in differential optical absorption measurements. A DIfferential Absorption Light detection and ranging (DIAL)application for the monitoring of atomic gaseou
Rheumatoid arthritis (RA) is a chronic autoimmune disease with a largely unknown aetiology. The risk of developing RA is partly dependent on genetic factors, which has motivated extensive efforts to identify the disease regulating genes as away to understand disease pathogenesis. However, identifying genes controlling complex diseases such as RA has proven extremely difficult and to date only a fe
Syftet med rapporten är att presentera en riskbaserad metod för brandteknisk dimensionering genom beräkning samt att exemplifiera hur denna kan användas. Det finns olika metoder att dimensionera en byggnad så att egenskapskraven angående brandsäkerhet följs. En av dem är att följa de råd som finns i byggreglerna och därigenom dimensionera brandsäkerheten genom så kallad förenklad dimensionering. O
