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Insertions and deletions of nucleotides in the genes encoding the variable domains of antibodies are natural components of the hypermutation process, which may expand the available repertoire of hypervariable loop lengths and conformations. Although insertion of amino acids has also been utilized in antibody engineering, little is known about the functional consequences of such modifications. To i

Background: The time course of infarct evolution, i.e. how fast myocardial infarction (MI) develops during coronary artery occlusion, is well known for several species, whereas no direct evidence exists on the evolution of MI size normalized to myocardium at risk (MaR) in man. Despite the lack of direct evidence, current literature often refers to the "golden hour" as the time during which myocard

With its focus on gender, the aim of this study was to investigate the role of work locus of control (WLC) for job satisfaction and health in the context of occupational stress. Data were collected from 281 women and men at both managerial and non-managerial level in a Swedish telecom company. As hypothesized, external WLC was positively related to stressors and symptoms of ill-health, whereas it

Objective. To explore risk factors for acute myocardial infarction (AMI) mortality in hypertensive patients treated in primary care. Design. Community-based cohort study. Setting. Hypertension outpatient clinic in primary health care. Subjects. Patients who consecutively underwent an annual follow-up during 1992-1993 (n =894; 377 men and 517 women). Methods. All events of fatal AMI were ascertaine

We prove a blow-up result for a nonlinear shallow water equation by showing that certain initial profiles evolve into breaking waves.

This study addressed the effects of apnea in air and apnea with face immersion in cold water (10 degrees C) on the diving response and arterial oxygen saturation during dynamic exercise. Eight trained breath-hold divers performed steady-state exercise on a cycle ergometer at 100 W. During exercise, each subject performed 30-s apneas in air and 30-s apneas with face immersion. The heart rate and ar

The posterior medial parietal cortex and the left prefrontal cortex have both been implicated in the recollection of past episodes. In order to clarify their functional significance, we performed this functional magnetic resonance imaging study, which employed event-related source memory and item recognition retrieval of words paired with corresponding imagined or viewed pictures. Our results sugg

Rotational Coherent anti-Stokes Raman spectroscopy (CARS) has the last decades been developed into a useful tool for thermometry and concentration measurements in combustion. In this paper, we present a novel polarization approach of the technique, which will enhance its potential and widen the range of conditions at which it can be utilized. The theory of the polarization approach is described in

A system modeling two phase flow in porous medium is discussed. The model consists of a weakly hyperbolic part describing the convection and a stiff rate equation modeling the adsorption. Well-posedness of the equilibrium system is reviewed and stiff well-posedness of a linearized version of the full system with relaxation is analyzed in detail.

This paper discusses the impact of flexibility when designing a Viterbi decoder for both convolutional and TCM codes. Different trade-offs have to be considered in choosing the right architecture for the processing blocks and the resulting hardware penalty is evaluated. We study the impact of symbol quantization that degrades performance and affects the wordlength of the rate-flexible trellis data

A model describing the performance of a fuel cell based on 10 mol% gadolinia-doped ceria, Ce0.9Gd0.1O1.95−x (CG10), was formulated. The total electrical conductivity of CG10 was measured under very reducing conditions in the temperature range of 753 K to 948 K. Oxygen permeation experiments were carried out to measure the leak current through a ceria electrolyte. The results of the measurements ar

Calmodulin is an essential Ca2+-binding protein that binds to a variety of targets that carry out critical signaling functions. We describe the proteomic characterization of mouse brain Ca2+-calmodulin-binding proteins that were purified using calmodulin affinity chromatography. Proteins in the eluates from four different affinity chromatography experiments were identified by 1-DE and in-gel diges

The aim of the present study was to identify water channel(s) which are expressed specifically in the growth zone of grass leaves and may facilitate growth-associated water uptake into cells. Previously, a gene had been described (HvEmip) which encodes a membrane intrinsic protein (MIP) and which is particularly expressed in the base I cm of barley primary leaves. The functionality of the encoding

The expanding capacity and the stabilizing function of an alpha-crystalline emulsifier on the bubble surfaces during and after expansion of a sugar foam were examined by volume measurements, confocal laser scanning microscopy (CLSM), freeze-etching and transmission electron microscopy (TEM) and oscillatory theological measurements. 0.2-10% (w/w) emulsifier, either a polyglycerol ester mixed with m

The utility of R-2(2)(9) biimidazole-carboxylate, R-2(2)(10) biimidazole-oxalate/squarate and R-2(2) (9) biimidazole-(tris-oxalate) synthons is considered for crystal engineering of hydrogen-bonded networks based on [Co-III(H(2)biim)(3)](3+) cations (H(2)biim = 2,2-biimidazole) and oxalate, squarate or [M-III(C2O4)(3-) anions. Syntheses and crystal structures are described for [Co-III(H(2)biim)(3)

Objective: The aim of this study was to determine the effects a course of instruction about irritable bowel syndrome (IBS) might have on symptoms, psychological well-being, and medical care requirements in these patients. Methods: Twenty-nine women with IBS participated in a programme of instruction on medical care, physical activity, stress-management, diet and health insurance. The women complet

Co-ordination of breathing and swallowing is essential for normal pharyngeal function and to protect the airway. To allow for safe passage of a bolus through the pharynx, respiration is interrupted (swallowing apnoea); however, the control of airflow and diaphragmatic activity during swallowing and swallowing apnoea are not fully understood. Here, we validated a new airflow discriminator for detec

OBJECTIVES: To compare the prognostic significance of chromosome aberrations, DNA ploidy, and S-phase fraction (SPF) in prostate adenocarcinomas and to compare the sensitivity of metaphase cytogenetics with flow cytometry (FCM) in detecting abnormal tumor clones. METHODS: Prostate adenocarcinomas from 57 men were previously successfully analyzed with metaphase cytogenetics. Archival material from