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A strategy for identifying putative causes of gene expression variation in human cancers

The majority of microarray studies focus on analysis of gene expression differences between various specimens or conditions. However, the causes of this variability from one cancer to another, from one sample to another and from one gene to another often remain unknown. In this study, we present a systematic procedure for finding genes whose expression levels are altered due to an intrinsic or ext

Nitric oxide is a regulator of mucociliary activity in the upper respiratory tract

The in vitro effects of the nitric oxide (NO) substrate L-arginine on ciliary beat frequency and the in vivo effects of the NO donor sodium nitroprusside (SNP) on mucociliary activity were investigated in the rabbit maxillary sinus mucosa with photoelectric techniques. L-Arginine increased ciliary beat frequency in vitro with a maximum response of 27.1% +/- 6.4% at 10(-3) mol/L, and this effect wa

Self-assessed and directly measured occupational physical activities - influence of musculoskeletal complaints, age and gender

This study compares questionnaire assessed physical activity with direct technical measurements among cleaners and office workers, stratified regarding age, gender and self-reported neck/shoulder complaints. During two full working days number of steps was recorded by a pedometer, sitting/standing positions by a posimeter and heart rate by a Sport-Tester. In addition the subjects kept a work task

Fosterbarns perspektiv på socialtjänstens företrädare

Artikeln gör en åtskillnad mellan omvärldens barnperspektiv och barns eget perspektiv. Med hjälp av ett antal mindre studier belyses barns perspektiv och socialtjänsten och de socialsekreterare, som de mött i samband med samhällsvård. Dessa visar att barn har olika synpunkter och erfarenheter beroende på var i omhändertagandeprocessen de tillfrågats, om de är nöjda eller missnöjda med placeringen

Levator co-activation is a significant confounder of pelvic organ descent on Valsalva maneuver.

Objective A Valsalva maneuver is used clinically and on imaging in order to determine female pelvic organ prolapse. We have examined the Potential confounding effect of levator co-activation at the time of a Valsalva maneuver and the impact of repetition with biofeedback instruction. Methods Fifty nulliparous women at 36-38 weeks' gestation received 3D/4D translabial ultrasound investigation in th

Positioning the Bronze Age in Social Theory and Research Context

Popular Abstract in Swedish Avhandlingen undersöker den teoretiska bakgrund och den forskningskontext inom vilken tolkningar av den Nordiska bronsåldern har formats. Avhandlingens teoretiska analys betonar teorier om social praxis och fenomenologiska perspektiv. Analysens syfte är att undersöka hur teorierna kan användas som verktyg för att förstå den dynamiska relationen mellan bronsålderns materThe thesis investigates the theoretical background and the research context within which interpretations of the Nordic Bronze Age have been formed in Scandinavian archaeology. A theoretical analysis that emphasises theories of social practice and phenomenological perspectives is presented. The purpose of the analysis is to explore theories of social practice as tools for grasping the dynamic relat

Penicillin-resistant pneumococci in Sweden 1997-2003: Increased multiresistance despite stable prevalence and decreased antibiotic use

Antimicrobial resistance patterns and capsular groups of penicillin-resistant Streptococcus pneumoniae (PRP; MIC penicillin G >= 0.5 mg/ml) in Sweden between 1997 and 2003 were described, and trends in resistance and antibiotic sales during the same period were compared. The most common serogroups were in descending order 9, 19, 14, 23, and 6. Despite a low and stable annual PRP rate (proportion o

Purification of protein and recycling of polymers in a new aqueous two-phase system using two thermoseparating polymers

In this study we present a new aqueous two-phase system where both polymers are thermoseparating. In this system it is possible to recycle both polymers by temperature induced phase separation, which is an improvement of the aqueous two-phase system previously reported where one of the polymers was thermoseparating and the other polymer was dextran or a starch derivative. The polymers used in this

Knarr i spånskivegolv på cellplast

Beskrivning av metod att åtgärda redan knarrande golv. Enkät om hittills använda reparationsmetoder. Förslag till läggningsmetod för nybyggnad med mellanlägg mellan plast och spånskiva.

Endothelial relaxing 5-hydroxytryptamine receptors in the rat jugular vein: similarity with the 5-hydroxytryptamine1C receptor

Serotonin (5-HT) at low concentrations induces an endothelium-dependent relaxation in the rat jugular vein mediated via a 5-HT1-like receptor. The receptor mediating this relaxation was characterized in vitro using agonists and antagonists in segments precontracted with prostaglandin F2 alpha in the presence of the 5-HT2 receptor antagonist ketanserin. The following substances acted as agonists, w

Levitated droplet dye laser

We present the first observation, to our knowledge, of lasing from a levitated, dye droplet. The levitated droplets are created by computer controlled pico-liter dispensing into one of the nodes of a standing ultrasonic wave (100 kHz), where the droplet is trapped. The free hanging droplet forms a high quality optical resonator. Our 750 nL lasing droplets consist of Rhodamine 6G dissolved in ethyl

Interpolating monthly precipitation by self-organizing map (SOM) and multilayer perceptron (MLP)

There are needs to find better and more efficient methods to interpolate precipitation data in space and time. Interpolation of precipitation is explored using a self-organizing map (SOM) in a region with large complexity of precipitation mechanisms (northern Iran). The technique is used both for regionalization and for interpolating monthly precipitation for stations with missing data for 1-, 2-,

Simultaneous reduction of SO2 and NOx in an entrained-flow reactor

Simultaneous SO2 and NOx reduction in flue gas by the dry furnace sorbent injection process was simulated with an entrained-flow reactor. Several ammonium salts as well as urea were tested. Urea was found to give the highest NOx removal efficiency. By using urea-limestone sorbent, >90% SO2 removal and >80% NOx removal were obtained at Ca/S and N/NOx ratios both equal to 2. The DeNO(x) process is m

On error rates in normal approximations and simulation schemes for Levy processes

Let X = (X(t) : t greater than or equal to 0) be a Levy process. In simulation, one often wants to know at what size it is possible to truncate the small jumps while retaining enough accuracy. A useful tool here is the Edgeworth expansion. We provide a third order expansion together with a uniform error bound, assuming third Levy moment is 0. We next discuss approximating X in the finite variation

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype fo