Treatment of tumour cell with 5-aza-2-deoxycytidine (DAC) for immune tumour therapy of Glioma in Fischer-344 rats
Fisher 344 rats with implanted N29 glioma tumours were treated with Pulsed Electric Fields (PEF) in combination with immunization using either IFN-gamma-gene-transfected syngeneic tumour cells or IFN-gamma transfected N29 cells treated with 10 micro-M 5-aza-2-deoxycytidine (DAC). Tumours (N29) were inoculated subcutaneously on both thighs of female F- 344 syngeneic rats. The left tumour was treate