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The early form of Integrated Water Resources Management (IWRM) emerged in the USA in the 1900s in order to manage interactions between water, land, eco- and social systems. By the end of the last century, IWRM has become a globally prominent policy concept. We concern ourselves with three questions, namely, a) “why did IWRM become a globally popular concept”?; b) “how did IWRM become a globally po
Background Care of old people with multimorbidity living at home is often fragmented with lack of coordination and information exchange between health care professionals, the elderly and their relatives. This paper describes the protocol of a randomised, controlled study, which aims to compare the efficacy of caring for older people with multimorbidity and three or more hospital admissions in the
Background: The International Consortium for Health Outcomes Measurement (ICHOM) was founded in 2012 to propose consensus-based measurement tools and documentation for different conditions and populations.This article describes how the ICHOM Older Person Working Group followed a consensus-driven modified Delphi technique to develop multiple global outcome measures in older persons. The standard se
The costs and consequences of donepezil versus placebo treatment in patients with mild to moderate Alzheimer's disease (AD) were evaluated as part of a 1-year prospective, double-blind, randomized, multinational clinical trial. Patients received either donepezil (n = 142; 5 mg/day for 28 days followed by 10 mg/day according to the clinician's judgement) or placebo (n = 144). Unit costs were assess
INTRODUCTION: Despite favourable results from structured face-to-face treatment of osteoarthritis (OA) in Sweden through the Better management of patients with OsteoArthritis (BOA) initiative, only around 20% of people with knee or hip OA receive the primary treatment recommended by international guidelines (ie, information, exercise, weight management). In 2014, a digital treatment programme name
For an open set V subset of C-n, denote by M-alpha(V) the family of a-analytic functions that obey a boundary maximum modulus principle. We prove that, on a bounded "harmonically fat" domain Omega subset of C-n, a function f is an element of M-alpha (Omega\f(-1)(0)) automatically satisfies f is an element of M-alpha(Omega), if it is C alpha j-1-smooth in the z(j) variable, alpha is an element of Z
I ”En allians av något slag” ger Mikael Hermansson ny kunskap om den sällan skildrade relationen mellan Svenska kyrkan och Church of England, och erbjuder nya perspektiv på det stora, svenska skiftet under 1900-talet – från en tysk kultursfär till en anglosaxisk.Redan vid slutet av 1800-talet visade Church of England ett gryende intresse för Svenska kyrkan. De ville upprätta ”en allians av något sWith a certain definition of ”networks”, “trust” and “change” this thesis makes new inroads into the historiography of bilateral church relations. Applied to the ambitions of establishing a deeper connection between the Church of Sweden and the Church of England, it’s aim is to show how a social network of leaders – mostly bishops and priests – from both churches came to be the formative centre of
The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product. Forced expression of SCL/tal-1 strongly induces blood formation in embryos, indicating that this gene has a dominant role in commitment to haematopoiesis. In
The 100 000 Genome Project aims to develop a diagnostics platform by introducing whole genome sequencing (WGS) into clinical practice. Samples from patients with chronic lymphocytic leukaemia were subjected to WGS. WGS detection of single nucleotide variants and insertion/deletions were validated by targeted next generation sequencing showing high concordance (96·3%), also for detection of sub-clo
Alla ryggradsdjur har ett immunförsvar vars funktion är att skydda oss mot mikroorganismer som kan orsaka sjukdom, såsom bakterier och virus. Dessa sjukdomsframkallande ämnen kallas patogener. Immunförsvaret behöver kunna skilja mellan proteiner som kommer från den egna kroppen och från patogener. Molekylerna som kodas av gener i major histocompatibility complex (MHC) har en viktig del i denna igeThe function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. There are two main types of MHC molecules, class-I (MHC-I) and class-II (MHC-II) and the focus of my thesis has been MH
In the study presented in this paper, a vehicle driving cycle simulation of the pneumatic hybrid has been conducted. The pneumatic hybrid powertrain has been modeled in GT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been converted to wor
