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OBJECTIVE: 5-azacytidine (azacytidine), a DNA hypomethylating agent, was recently approved as the first therapeutic agent for the treatment of myelodysplastic syndromes. The present subcutaneous dosing schedule, 75 mg/m(2) for 7/28 days, is based on early clinical studies and may constitute a practical problem for patients. The present in vitro study aimed at evaluating the pharmacodynamics of aza
Popular Abstract in Swedish Den pågående ökningen av växthusgaser i atmosfären orsakar en ökning av den globala medeltemperaturen. En viktig påverkande faktor för koncentrationen koldioxid (CO2) i atmosfären är utbytet mellan atmosfären och biosfären; fotosyntesen tar upp CO2 och respirationen släpper ut CO2, vilket resulterar i ett nettoutbyte. För att öka vår förståelse av den spatiala och tempoThe ongoing increase in atmospheric greenhouse gas concentrations causes an increase in the global mean air temperature. One important moderator of the atmospheric carbon dioxide (CO2) concentration is the gas exchange between the atmosphere and the biosphere; photosynthesis extracts and respiration releases CO2, resulting in a net exchange. A variety of methods are used to improve our understandi
Households base their choices of heating systems on subjectively dependent conceptions of heating sources, rather than on an understanding of a complex reality. Similar to other agents in society, households need to construct simplified frames to be able to make their choices possible to manage. Using in-depth interviews with households in Småland (in Sweden) with a few comparisons from Massachuse
Human postural dynamics was investigated in twelve normal subjects by means of a force platform recording body sway induced by bipolar transmastoid galvanic stimulation of the vestibular nerve and labyrinth. We modeled the stabilizing forces actuated by the feet as resulting from complex muscular activity subject to feedback of body velocity and position. Time series analysis demonstrated that a t
Specific molecular recognition materials are important in analytical applications. It has been a longstanding dream for scientific explorers to realise a versatile method to generate materials that can recognize biological and chemical substance of interests. Toward this goal, developing synthetic polymer materials, molecularly imprinted polymers (MIPs) is one of the most promising approaches. Esp
Correlations in the azimuthal angle between dijets produced in deep inelastic e(+)p scattering events have been investigated. Cross sections are presented as a function of the azimuthal separation between the two jets in the hadronic center of mass frame, Delta phi*, in different regions of the photon virtuality Q(2) and in different regions of the Bjorken scaling variable x(Bj). The results are c
Scania has performed well above average in the heavy truck industry during a considerable time span. Scania's sources of competitive advantage are presented and their interrelations and significance for the business strategy analysed in order to explain the success of Scania. Strategic issues are traditionally analysed in a top-down procedure starting with the corporate strategy and proceeding by
