The differential signalling of the succinate receptor SUCNR1/GPR91, through Gi versus Gq
G protein-coupled receptors are the biggest family of membrane bound receptor in the human genome, they are also target for many drugs due to their accessible location in the cell membrane. We have characterized the G protein recruitment of the succinate receptor 1 (SUCNR1/GPR91). GPR91 was deorphanized in 2004 and already then it was suggested that GPR91 could couple to the Gi-family and the Gq-f