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Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice

The importance of adequate levels of muscle size and function and physical activity is widely recognized. Myostatin/activin blocking increases skeletal muscle mass but may decrease muscle oxidative capacity and can thus be hypothesized to affect voluntary physical activity. Soluble activin receptor IIB (sActRIIB-Fc) was produced to block myostatin/activins. Modestly dystrophic mdx mice were inject

Lower head temperature does not affect children's self-paced running velocity

To test if the use of a peaked cap protects children against sun radiation, allowing increased exercise performance, nineteen healthy children (10.3 ± 0.8 years old, 146.2 ± 6.9 cm, 36.8 ± 5.5 kg, 1.2 ± 0.1 m2 and 44.1 ± 2.8 mL.kg-1.min-1) took part in 4 experimental situations: 2 initial familiarization runs and 2 self-paced 6km runs (4 × 1.5 km exercise bouts with 3min rest intervals) one of the

Sinoaortic denervation prevents enhanced heat loss induced by central cholinergic stimulation during physical exercise

The present study investigated whether the effects of central cholinergic stimulation on thermoregulation during exercise are modulated by arterial baroreceptors. Wistar rats were submitted to sinoaortic denervation (SAD) or sham denervation (SHAM) and then fitted with a chronic guide cannula into the lateral cerebral ventricle. After 2 weeks, a catheter was implanted into the ascending aorta, and

Borehole logging and slug tests for evaluating the applicability of electrical resistivity tomography for groundwater exploration in Nampula complex, Mozambique

In Nampula province, Mozambique, there is a high number of water wells considered as having failed for having too low a pumping yield. Two Electrical Resistivity Tomography (ERT) measurement campaigns were conducted in the area for evaluating the reasons of failures. However, in some cases it was difficult to verify and interpret the ERT results by only using the inadequate lithological descriptio

Probing insect backscatter cross section and melanization using kHz optical remote detection system

A kHz optical remote sensing system is implemented to determine insect melanization features. This is done by measuring the backscatter signal in the visible and near-infrared (VISNIR) and short-wave infrared (SWIR) in situ. It is shown that backscatter cross section in the SWIR is insensitive to melanization and absolute melanization can be derived from the ratio of backscatter cross section of d

Hydrologic response of climate change in the source region of the Yangtze River, based on water balance analysis

Due to the large amount of water resources stored in glaciers, permafrost, and lakes, the source region of the Yangtze River (SRYR) is of great importance for the overall basin water flow. For this purpose, a state of art review and calculations were made for the period 1957-2013 using observed hydrological and meteorological data with a water balance approach. Actual evapotranspiration was calcul

Systematic review describing the effect of early mobilisation after dysvascular major lower limb amputations

Aims and objectives: To assess the effect of early mobilisation of patients after dysvascular lower limb amputation and to compare the effectiveness of different mobilisation regimens. Background: Patients who have undergone dysvascular major lower limb amputations are at high risk of postoperative complications, which include loss of basic functions, and early mobilisation interventions might pre

Pollinator population size and pollination ecosystem service responses to enhancing floral and nesting resources

Modeling pollination ecosystem services requires a spatially explicit, process-based approach because they depend on both the behavioral responses of pollinators to the amount and spatial arrangement of habitat and on the within- and between-season dynamics of pollinator populations in response to land use. We describe a novel pollinator model predicting flower visitation rates by wild central-pla

Migration strategies and annual space-use in an Afro-Palaearctic aerial insectivore - the European nightjar Caprimulgus europaeus

Obligate insectivorous birds breeding in high latitudes travel thousands of kilometres during annual movements to track the local seasonal peaks of food abundance in a continuously fluctuating resource landscape. Avian migrants use an array of strategies when conducting these movements depending on e.g. morphology, life history traits and environmental factors encountered en route. Here we used ge

Turnover and post-bottleneck genetic structure in a recovering population of Peregrine Falcons Falco peregrinus

Dispersal is a process that increases genetic diversity and genetic connectivity of populations. We studied the turnover rate of breeding adults and genetic population structure to estimate dispersal in Peregrine Falcons in Finland. We used relatedness estimates among Finnish Peregrine Falcons over a 5-year period, genotyping over 500 nestlings with 10 microsatellite loci to reveal the rate of tur

Could changing power relationships lead to better water sharing in Central Asia?

Even though Central Asia is water rich, water disputes have characterized the region after crumbling of the Soviet Union in 1991. The uneven spatial distribution and complex pattern of transboundary water sources with contrasting national water needs have created an intricate water dilemma. Increasing national water needs, water claims by surrounding countries, uncertainties in renewable water vol

A Factor Analytical Approach to Price Discovery

Existing econometric approaches for studying price discovery presume that the number of markets are small, and their properties become suspect when this restriction is not met. They also require making identifying restrictions and are in many cases not suitable for statistical inference. The current paper takes these shortcomings as a starting point to develop a factor analytical approach that mak

Methods to identify the prey of invertebrate predators in terrestrial field studies

Predation is an interaction during which an organism kills and feeds on another organism. Past and current interest in studying predation in terrestrial habitats has yielded a number of methods to assess invertebrate predation events in terrestrial ecosystems. We provide a decision tree to select appropriate methods for individual studies. For each method, we then present a short introduction, key

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds

A new generation of potent hDHODH inhibitors designed by a scaffold-hopping replacement of the quinolinecarboxylate moiety of brequinar, one of the most potent known hDHODH inhibitors, is presented here. Their general structure is characterized by a biphenyl moiety joined through an amide bridge with an acidic hydroxyazole scaffold (hydroxylated thiadiazole, pyrazole and triazole). Molecular model

The complex genetics of gait speed : Genome-wide meta-analysis approach

Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consort