AZD5423 is a selective glucocorticosteroid receptor modulator developed for the inhaled use in asthma and COPD. This study reports the initial, first-in-man, single and repeat dose-escalating studies in healthy male individuals, including one cohort of male Japanese individuals. Inhaled, nebulized AZD5423 was safe and well tolerated up to and including the highest doses tested for up to 2 weeks of

Current research investigates automation feedback design compared with a potential design solution that may increase pilot’s situation awareness of the Flight Mode Annunciators (FMAs) to reduce pilot workload and improve human-automation coordination. The research tools include an Eye Tracker and B747 flight simulator. This research evaluated two types of FMAs; a proposed glareshield mounted FMAs

The new compounds and potential ligands 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethyldiphenlyphosphinite (L1), 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethyldiethylphosphite (L2), 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethyl-diethylphosphite (L3) and 2-(3,5-diphenyl-1H-pyrazol-1-yl)ethyldiethylphosphite (L4) were prepared from the reaction of (3,5-(disubstituted)pyrazol-1H-yl)ethanol and the appropriate ph

Objectives To examine predictors of work ability gain and loss after anti-tumour necrosis factor (TNF) start, respectively, in working-age patients with rheumatoid arthritis (RA) with a special focus on disease duration. Methods Patients with RA, aged 19-62 years, starting their first TNF inhibitor 2006-2009 with full work ability (0 sick leave/disability pension days during 3 months before bio-st

TO-DCF, a new backoff scheme for 802.11, has the potential to significantly increase throughput in dense wireless LANs while also opportunistically favouring nodes with heavier traffic loads and/or better channel conditions. In this paper we present an analytical model to investigate the behaviour and performance of the TO-DCF protocol with regards to operating parameters such as the number of nod

The novel double-working-electrode electrochemical system with air diffusion cathode (ADC) and Ti/SnO2-Sb anode (TSSA) has shown higher efficiency and lower energy consumption for the degradation of organic pollutant from high-salinity wastewater, compared to the traditional single anode system. To further investigate and improve this system, in this work, firstly the effect of vital factors of th

In this article, in the light of the important epistemological changes in human sciences since the 80’s, which had the merit of clarifying the foundations of modern scientific nature, we focus on the difficulties in classifying the orally transmitted material. We show, that the question is not so much what we talk about, when we talk about genres, but how we talk about it. We demonstrate that the

This study reviews literature on the aspects of material selection within the field of industrial design education, specifically focusing on existing material selection tools and guidelines used in industrial design education. The growing number of materials available today has created a large variety of options for industrial designers, which they are ill-equipped to handle. A key reason behind t

In the works of Can Xue, houses and buildings act as the outer shell of the fragile self. Her depiction of these uncanny places of inhabitance questions the rationalist notion of an objective border between self and surroundings, paving the way for a subjective and phenomenological approach to reality.

Conditional random fields were trained to detect marker words for negation and speculation in two corpora belonging to two very different domains: clinical text and consumer review text. For the corpus of clinical text, marker words for speculation and negation were detected with results in line with previously reported interannotator agreement scores. This was also the case for speculation marker

This article demonstrates that typical restrictions which are imposed in dialogical logic in order to recover first-order logical consequence from a fragment of natural language argumentation are also forthcoming from preference profiles of boundedly rational players, provided that these players instantiate a specific player type and compute partial strategies. We present two structural rules, whi

The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Here we report on the serendipitous discovery of 20 Li-rich giants observed during the Gaia-ESO Survey, which includes the first nine Li-rich giant stars known towards the CoRoT fields. Most of our Li-rich giants have near-solar metallicities and stellar parameters consistent with being before the lumin

Climate change could pose a major challenge to efforts towards strongly increase food production over the coming decades. However, model simulations of future climate-impacts on crop yields differ substantially in the magnitude and even direction of the projected change. Combining observations of current maximum-attainable yield with climate analogues, we provide a complementary method of assessin