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Rapid and Green Separation of Mono- and Diesters of Monochloropropanediols by Ultrahigh Performance Supercritical Fluid Chromatography-Mass Spectrometry Using Neat Carbon Dioxide as a Mobile Phase

This study demonstrates the effect of column selectivity and density of supercritical carbon dioxide (SC-CO2) on the separation of monochloropropanediol (MCPD) esters, known as food toxicants, using SC-CO2 without addition of cosolvent in ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). This study shows that over 20 2-monochloropropanediol (2-MCPD) and 3-mono

Hyperparameter Selection for Group-Sparse Regression: A Probabilistic Approach

This work analyzes the effects on support recovery for different choices of the hyper- or regularization parameter in LASSO-like sparse and group-sparse regression problems. The hyperparameter implicitly selects the model order of the solution, and is typically set using cross-validation (CV). This may be computationally prohibitive for large-scale problems, and also often overestimates the model

Combined coagulation and ultrafiltration process to counteract increasing NOM in brown surface water

Membrane hybrid processes-coagulation coupled with ultrafiltration (UF)-have become a common method to comply with the legal, chemical, and microbiological requirements for drinking water. The main advantages of integrating coagulation with membrane filtration are the enhanced removal of natural organic matter (NOM) and reduced membrane fouling. With in-line coagulation, coagulants are patched int

Sparse Multi-Pitch and Panning Estimation of Stereophonic Signals

In this paper, we propose a novel multi-pitch estimator for stereophonic mixtures, allowing for pitch estimation on multi-channel audio even if the amplitude and delay panning parameters are unknown. The presented method does not require prior knowledge of the number of sources present in the mixture, nor on the number of harmonics in each source. The estimator is formulated using a sparse signal

Self-assessed remission rates after electroconvulsive therapy of depressive disorders

Background Electroconvulsive therapy (ECT) effectively treats severe depression, but not all patients remit. The aim of the study was to identify clinical factors that associate with ECT-induced remission in a community setting. Methods Depressed patients who underwent ECT in 2011–2014 were identified from the Swedish National Quality Register for ECT. Remission was defined as self-rated Montgomer

Anomalous Evolution of the Near-Side Jet Peak Shape in Pb-Pb Collisions at sNN =2.76 TeV

The measurement of two-particle angular correlations is a powerful tool to study jet quenching in a pT region inaccessible by direct jet identification. In these measurements pseudorapidity (Δη) and azimuthal (Δφ) differences are used to extract the shape of the near-side peak formed by particles associated with a higher pT trigger particle (1

Braided Convolutional Codes with Sliding Window Decoding

In this paper, we present a novel sliding window decoding scheme based on iterative Bahl-Cocke-Jelinek-Raviv decoding for braided convolutional codes, a class of turbo-like codes with short constraint length component convolutional codes. The tradeoff between performance and decoding latency is examined and, to reduce decoding complexity, both uniform and nonuniform message passing schedules withi

Blocking CGRP in migraine patients – a review of pros and cons

Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than migraine such as hypertension, depression and epilepsy. During the last decade, however, blocking calcitonin gene-related peptide (CGRP) has emerged as a possible mechanism for prevention of mi

Use of automated chest compression devices after out-of-hospital cardiac arrest in Sweden

Objective To evaluate the implementation of automated chest compression cardiopulmonary resuscitation (ACC-CPR) after out-of-hospital cardiac arrest (OHCA) in Sweden during the years 2011 through 2015. The association between ACC-CPR and 30-day survival was studied as a secondary objective. Methods The Swedish cardiopulmonary resuscitation registry is a prospectively recorded nationwide registry o

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes

Aims/hypothesis: There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data integration to determine the validity of published evidence. Methods: We (1) buil

Term amniotic fluid : An unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications

Background: Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease modelling, pharmaceutical screening, and regenerative medicine by applying reprogramming technologies. However, the limited availability of MSCs from various

The role of fermentable carbohydrates and beverages in the symptomatology of functional gastrointestinal disease

Objectives: The pathophysiology behind functional gastrointestinal disease (FGID) has not been defined, but an intestinal accumulation of fermentable short-chain carbohydrates (FODMAPs) is thought to be involved. A restricted coffee intake is recommended. The aim was to investigate if symptoms of FGID were associated with intake of certain foods (including FODMAPs), as well as beverages (including

Societal challenges of precision medicine : Bringing order to chaos

The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome-wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective personalised treatment based on the often complex genomic signature of their tumour. For such approaches to work in routine practice, the

Remote ischemic preconditioning protects human neural stem cells from oxidative stress

In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits

Scaling up solar photovoltaic use : A system-oriented assessment of experiences gained in deployment

The transition towards low-carbon energy systems undeniably requires a strong scale-up in the diffusion of renewable energy technologies globally. Given its theoretical and techno-economic potential, solar photovoltaics (PV) is considered an important option. The envisioned scale-up of the use of solar PV, however, requires an in-depth and system-oriented perspective on structures and processes re

Patients' views on early sensory relearning following nerve repair-a Q-methodology study

Study Design: Descriptive study. Introduction: Early sensory relearning where the dynamic capacity of the brain is used has been shown to improve sensory outcome after nerve repair. However, no previous studies have examined how patients experience early sensory relearning. Purpose of the Study: To describe patient's views on early sensory relearning. Methods: Statements' scores were analyzed by f

A tunable electron beam source using trapping of electrons in a density down-ramp in laser wakefield acceleration

One challenge in the development of laser wakefield accelerators is to demonstrate sufficient control and reproducibility of the parameters of the generated bunches of accelerated electrons. Here we report on a numerical study, where we demonstrate that trapping using density down-ramps allows for tuning of several electron bunch parameters by varying the properties of the density down-ramp. We sh

Source deghosting by depth apparition

Marine seismic data are distorted by ghosts as waves propagating upward reflect downward from the sea surface. Ghosts appear on the source side and the receiver side. However, whereas the receiver-side ghost problem has been studied in detail, and many different solutions have been proposed and implemented commercially, the source-side ghost problem has remained largely unsolved with few satisfact