Filetype
Eutrophication and global warming are key drivers of oxygen loss, also termed deoxygenation, in coastal ecosystems worldwide. Artificial reoxygenation has been suggested as a local or regional solution to increase oxygen concentrations and improve water quality by various parties, including water managers and industry. Three main approaches have been proposed: (1) bubbling with air with the aim to
Background: Primary tumor volume (GTVp) is a key prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC) treated with radiotherapy. We aimed to externally validate this association and assess its relevance in other head and neck sites. Methods: Patients from the RADCURE dataset were analyzed using Cox regression for local failure, progression-free survival (PFS), and overall survival (O
In our study, we identified a general biogeographical pattern within bioregions. This pattern, called ‘core-to-transition’, largely reflects a covarying gradient in four biodiversity aspects from a single biogeographical core, not the geometrical centre, towards its permeable boundaries. Species richness and endemicity decline from the core, whereas biota overlap and species occupancy increase. Ad
This paper presents a pipeline which uses a multiatlas approach for multiorgan segmentation in whole-body CT images. In order to obtain accurate registrations between the target and the atlas images, we develop an adapted feature-based method which uses organ-specific features. These features are learnt during an offline preprocessing step, and thus, the algorithm still benefits from the speed of
Summary: Existing approaches to modelling antibody concentration data are mostly based on finite mixture models that rely on the assumption that individuals can be divided into 2 distinct groups: seronegative and seropositive. Here, we challenge this dichotomous modelling assumption and propose a latent variable modelling framework in which the immune status of each individual is represented along
Virtual Imaging Trials (VITs) provide a reproducible, cost-effective, and ethical approach for testing medical imaging technologies. In breast imaging, realistic phantoms across density levels are crucial, as density affects cancer risk assessment and imaging performance. We have previously demonstrated the use of Perlin noise to simulate breast parenchyma. This study establishes a systematic mapp
Bismuth-based compounds, such as Bi1-xSbx or Bi2Te3, have outstanding electronic properties especially for advanced quantum devices. However, the potential of low-dimensional group V-Bi materials is largely undetermined. Here, we report the experimental realization of a two-dimensional (2D) BiAs layer with giant Rashba spin splitting, grown on an InAs(111)B substrate via molecular beam epitaxy. AR
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may cause stress-induced transient acute cardiac dysfunction through myocardial stunning, in the form of exacerbation-triggered Takotsubo syndrome (referred to as Takotsubo stunning). Although prior studies suggest an association between AECOPD and transient cardiac dysfunction, existing evidence is limited to retro
The rapid adoption of electric vehicles (EVs) with increasingly advanced battery technologies is reshaping electricity demand patterns. Yet existing studies often assume static behaviors, overlooking that real-world charging patterns are transient and evolve in response to technological change. This study applies a scenario-aware generative modeling framework to project weekly EV charging demand i
With growing interest in cobalt-based complexes for electrocatalytic applications, we synthesized four homoleptic facial-octahedral Co(iii) β-oxodithioester complexes (1–4) with the general composition [Co(L)3], where L represents 3-(methylthio)-1-(furan-2-yl)-3-thioxoprop-1-en-1-olate (L1), 3-(methylthio)-1-(thiophen-2-yl)-3-thioxoprop-1-en-1-olate (L2), 3-(methylthio)-1-(pyridin-3-yl)-3-thioxopr
Cross-linguistic research shows that languages differ in how they encode the basic semantic components of motion events (figure, motion, manner, path, and ground) in their grammars and lexicons. While manner and path encoding have received significant attention, one core component has been underestimated: ground, the object or surface relative to which motion occurs. In fact, the possibility of gr
We present MixtureVitae, an open-access pretraining corpus1 built to minimize legal risk while providing strong downstream performance. MixtureVitae follows a permissive-first, risk-mitigated sourcing strategy that combines public-domain and permissively licensed text (e.g., CC-BY/Apache) with carefully justified low-risk additions (e.g., government works and EU TDM-eligible sources). MixtureVitae
Objective: To describe the epidemiology of injuries and illnesses at the Paris 2024 Paralympic Games. Methods: Injuries and illnesses were recorded daily via a web-based injury and illness surveillance system and local organising committee medical facilities. Adjusted incidences (injuries/illnesses per 1000 athlete days; 95% CIs), injury prevalence (IP; %) and injury burden (days lost per 1000 ath
Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promote muscle growth in humans, including to counter the muscle loss seen in obese humans using GLP1R agonists. In this study, we present results from a large multi-cohort genetic association analysis, using data from 1.1 million individuals to examine th
Previous experimental studies of pyrrole pyrolysis reported numerous hydrocarbon and nitrogen-containing products from HCN up to pyridine and dinitriles. To develop a consistent detailed kinetic mechanism for pyrrole, the rate constants of H atom abstraction from C4H5N by NH2, and CH2CN radicals have been calculated at the DLPNO-CCSD(T)-F12/cc-pVDZ-F12//M06–2X/def2-TZVP level of theory while H ato
Background and purpose: Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular endothelium may modulate BBB structural and functional dynamics, thereby affecting neuronal damage and recovery after ischemic stroke. The aim of this study was to investigate temporal and
This working paper examines Sweden’s Covid-19 vaccine procurement and distribution strategy as part of the SCANVAX project on Nordic vaccine diplomacy. Drawing primarily on a review of news media, parliamentary records, government reports and other documentary sources, the study analyses how Sweden worked to procure Covid-19 vaccines to cover the needs of Swedish residents, as well as how Sweden e
This volume explores the poetic and philosophical boundaries between humanity and divinity across the Hebrew Bible, Graeco-Roman literature, and early Christian thought. Inspired by Psalm 8 and the verses of Sappho and Catullus, the title evokes the ancient tension between being human and “almost divine.”Essays by leading scholars examine prophetic transmission, divine legitimization of power, asc
