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Newborns discriminate novel from harmonic sounds: A study using magnetoencephalography

Objective: We investigated whether newborns respond differently to novel and deviant sounds during quiet sleep. Methods: Twelve healthy neonates were presented with a three-stimulus oddball paradigm, consisting of frequent standard (76%), infrequent deviant (12%), and infrequent novel stimuli (12%). The standards and deviants were counterbalanced between the newborns and consisted of 500 and 750 H

Dithiolate complexes of manganese and rhenium: X-ray structure and properties of an unusual mixed valence cluster Mn-3(CO)(6)(mu-eta(2)-SCH2CH2CH2S)(3)

Treatment of Mn-2(CO)(10) with 3,4-toluenedithiol and 1,2-ethanedithiol in the presence of Me(3)NO(.)2H(2)O in CH2CI2 at room temperature afforded the dinuclear complexes Mn-2(CO)(6)(mu-eta(4)-SC6H3(CH3)S-SC6H3(CH3)S) (1), and Mn-2(CO)(6)(mu-eta(4)-SCH2CH2S-SCH2CH2S) (2), respectively. Similar reactions of Re-2(CO)(10) with 3,4-toluenedithiol, 1,2benzenedithiol, and 1,2-ethanedithiol yielded the d

Prevention of alcohol-related deaths in middle-aged heavy drinkers

BACKGROUND: Alcohol as a cause of death in middle-aged patients is well-known from clinical studies. A similarly important correlation in the general population of urban middle-aged men is highly underestimated. Health screening investigations have shown that mortality related to alcohol is five times more common in nonparticipants than in participants. From the mid-70s, the Malmoe Screening and I

Mental disorder is a cause of crime: The cornerstone of forensic psychiatry

The assumption that mental disorder is a cause of crime is the foundation of forensic psychiatry, but conceptual. epistemological. and empirical analyses show that neither mental nor crime, or the causation implied, are clear-cut concepts. "Mental" denotes heterogeneous aspects of a per-son such as inner experiences. cognitive abilities, and behaviour patterns described in a non-physical vocabular

Measurement of direct ethanol metabolites in a case of a former driving under the influence (DUI) of alcohol offender, now claiming abstinence

A 37-year-old female subject had been convicted of driving under the influence of alcohol, and 19 months later, claimed abstinence after supervised disulfiram treatment. Our aim was to elucidate the value of direct ethanol metabolites as measures of abstinence. Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE) in hair, phosphatidylethanol in whole blood and EtG and ethyl sulphate in urine

Relationships between satisfaction with occupational factors and health-related variables in schizophrenia outpatients

BACKGROUND: The purpose of this study was to explore relationships between satisfaction with occupational factors, operationalized as occupational status and the total daily occupational situation, and health-related variables among people with schizophrenia. The health-related variables included quality of life, perceived control, sense of coherence, and psychopathology. Gender differences in the

Surface structure and dynamics of block and graft copolymers having fluorinated poly(ethylene oxide) chain ends

The surface compositions of poly(styrene-b-ethylene oxide) and poly(styrene-g-ethylene oxide) films were found to be largely determined by the nature of the poly(ethylene oxide) (PEO) chain ends. Angle-dependent X-ray photoelectron spectroscopy revealed that polystyrene (PS) dominated the surfaces of the copolymers having PEO chain ends terminated by hydroxyl groups (SEO). Also, the PEO content de

Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?

Aims/hypothesis Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins. The aim of this study was to asse

Alpha-1-antitrypsin is present in the specific granules of human eosinophilic granulocytes

Eosinophils may be found at sites of inflammation, for example in asthma, allergy and helminthic infestation, but their role in human inflammatory disease is unclear. In the present study, we investigated the presence of alpha-1-antitrypsin (AAT), a serine proteinase inhibitor, in human eosinophils. When lysates of highly purified eosinophils were subjected to Western blotting, with a chemilumines