The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar

Wooded pasture and older forest with dead trees, about 10% of an area of 3000 ha in the central part of the parish of Stenbrohult, was inventoried for wood-living beetles in 1985-2002. In the study areas Carl Linnaeus was born in 1707, and he spent his summers there until 1728. All standard methods for finding wood-beetles were used, including many window traps and 170 wood mould samples. As a new

Objective. To examine the changes in health-related quality of life (HRQoL) in patients with coronary artery disease (CAD) in terms of age, gender, and treatment strategy in Iran. Methods and Materials. Forty-nine patients responded to the Iranian version of the 36-item short form (SF-36) questionnaire to evaluate the HRQoL at first and third year after treatment. The paired and independentWilcoxo

Prompted by persistent dissatisfaction with research and research publications in organization studies, we critically discuss the standardization of research and publications into formulaic patterns that constrain the imagination and creativity of scholars and restrict the social relevance of their work. Formulaic research involves extreme specialization, an incrementalist and ultra-cautious attit

Popular Abstract in Swedish Bakterier är små encelliga organismer som lever i nästan varje tänkbar miljö på jorden, inklusive i och på människor. Vi är kontinuerligt koloniserade av bakterier i bland annat våra luftvägar, munhålor och mag-tarmkanaler. Denna samexistens är oftast ömsesidigt fördelaktig, eller åtminstone ofarlig för oss människor, och det är känt att bakterier hjälper oss bryta ner Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to host tissue and evasion of the host innate immunity. We have shown that the NTHi virulence factor Pr

Background: Health inequality and its social determinants are well-studied, but the determinants of inequality of alcohol consumption are less well-investigated. Methods: The total differential approach of decomposition of changes in the concentration index of the probability of participation in alcohol consumption was applied to 8-year longitudinal data for Swedish women aged 28-76 in 1988/89. Re

Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38=) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the

Despite the wide diversity of available solar technologies, solar energy systems are still not considered as main stream technologies in building practice. This may be attributed to several factors such as lack of awareness and knowledge among architects, lack of tools supporting the design process, and lack of solar products designed for building integration. In order to address these issues, the

Lime–hemp concrete (LHC) is a sustainable building material that combines hemp shiv and building limes. Moisture fixation and thermal properties of LHC were determined so as to gain knowledge about the material’s behaviour in a cold, wet climate. Sorption isotherms were produced over the whole moisture range for two LHC mixes by means of glass jar tests and a pressure plate apparatus. Thermal prop

The water vapor interface of aqueous solutions of succinic acid, where pH values and bulk concentrations were varied, has been studied using surface sensitive X-ray photoelectron spectroscopy (XPS) and molecular dynamics (MD) simulations. It was found that succinic acid has a considerably higher propensity to reside in the aqueous surface region than its deprotonated form, which is effectively dep

The International Commission on Stratigraphy and the IUGS Executive Committee have recently approved a Global Standard Stratotype-section and Point (GSSP) defining the base of the second stage of the Furongian Series, Cambrian System. This stage is named the Jiangshanian Stage, after Jiangshan City, western Zhejiang Province, China, where the GSSP is located. The GSSP is exposed in a natural outcr

Experiments with birch bark samples have been carried to enable a distinction between extraction and degradation effects during pressurised hot water extraction. Two samples, E80 and El 80, contained birch bark extracts obtained after extraction at 80 and 180 degrees C for up to 45 min, respectively. Two other samples, P80 and P180, were only extracted for 5 min at the two temperatures and were th