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Portal hypertension was induced in rats by partial ligation of the hepatic branches of the portal vein. After 5 days of hypertension the portal veins were taken out and mounted for isometric and quick-release experiments. Portal veins from sham-operated normal rats served as controls. The ligated veins had an increased cross-sectional area, indicating smooth-muscle hypertrophy. Although the absolu

The utility of the GHOST(3) cell assay has been evaluated for testing coreceptor use of primary human immunodeficiency virus type 1 (HIV-1) isolates. GHOST(3) cells were derived from the human osteosarcoma cell line, HOS, and have been engineered to stably express CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, Bonzo, or the orphan receptor BOB. The Indicator cell line carries

Recension av Allan A. Lund, Mumificerede moselig.

Using an atomic model with a simplified-sequence-based potential, the folding properties of several different peptides are studied. Both alpha-helical (Trp cage, F-s) and beta-sheet(GB1p, GB1m2, GB1m3, Betanova, LLM) peptides are considered. The model is able to fold these different peptides for one and the same choice of;parameters, and the melting behaviour of the peptides (folded population aga

A coupled system, consisting of a conventional ion-exchange column and a chiral column, was used for separation of the D- and L-enantiomers as constituents of an amino acid mixture. The ion-exchange column was connected to an amino acid analyser and the eluents necessary for the chiral column were delivered by an HPLC pump. With this on-line system the D- and L-forms of eight of the proteinogenic

The preliminary results of a palynological investigation of 62 samples from the southern section of a sedimentary sequence exposed at Fossilryggen in the Vestfjella mountain range in Dronning Maud Land, Antarctica are reported. The sequence, which is cut by dolerite dykes, is considered to have been deposited in a near-shore marine environment. Palynomorphs recovered show high degrees of thermal a

The purpose of this study was to examine whether the quality of measured x-ray beam data can be judged from how well the data agree with a semiempirical formula. Tissue-phantom ratios (TPR) and output factors for several accelerators in the energy range 4-25 MV were fitted to the formula, separating the dose contributions from primary and phantom-scattered photons. The former was described by expo

So-called isothermal calorimeters are often built on the heat conduction principle. This may sound as a contradiction, as heat conduction is a result of non-isothermal conditions, but most measurements with microcalorimeters and other such instruments are essentially isothermal as the temperature differences within the instruments are in the order of 10 mK. This paper presents simple methods to es

Background: Non-linearities in observed log-ratios of gene expressions, also known as intensity dependent log-ratios, can often be accounted for by global biases in the two channels being compared. Any step in a microarray process may introduce such offsets and in this article we study the biases introduced by the microarray scanner and the image analysis software. Results: By scanning the same sp

Denna rapport har sammanställts på uppdrag av Skånska Cementgjuteriet, Malmö, och behandlar teoretiska metoder (eller "modeller") för beräkning av oarmerade betong rörs böjbrottlast och ringbrottlast.

R. M. Hare skriver första gången om superveniens i boken Language of Morals (LM). Han är inte den förste som understrukit att värdeomdömen handlar om så kallade supervenienta egenskaper – dvs. egenskaper som tillfaller bäraren av värdet i kraft av alla eller några av dess övriga egenskaper. Han ståtar dock i många arbeten med att ha varit den första som gav denna speciella relation ett namn. Det s

Objectives. To assess waiting times for three groups of orthopaedic patients in Sweden and to identify factors explaining variations in waiting time. Also examined were factors associated with patients' perceptions that waiting times were too long. Design. Retrospective study. Setting and study participants. Patients from orthopaedic units at 10 Swedish hospitals participated in the study. A quest

Foam generated by vigorous stirring of a nonionic detergent, Triton X-114, was used for the recovery of recombinant cutinase expressed by Saccharomyces cerevisiae. The enzyme with a hydrophobic fusion tag, (Trp-Pro)(4), was recovered with a higher yield as compared to the wild-type cutinase, indicating the involvement of hydrophobic interactions in protein isolation with the foam. The influence of

To gain further insight into the synthesis and structure of the synovial matrix of joints, we have established cell cultures from synovial specimens and elaborated their production of hyaluronan and proteoglycans. The cultures secreted mainly the small proteoglycan decorin, but also considerable amounts of the related biglycan and the large proteoglycan versican. Only minor amounts of heparan sulf

The intratracheal (i.t.) instillation of Sephadex beads into rat induced inflammation and a 30-fold increase in the endothelin-1-like immunoreactivity (ET-1-LI) of broncho-alveolar lavage fluid. The levels were highest 24 h after the instillation and had declined significantly after 48 h. At a dose of 1 mg kg-1 i.t., the glucocorticosteroid budesonide almost abolished this response. Phosphoramidon

Various transport phenomena in conjunction with chemical reactions are strongly affected by reformer configurations and properties of involved porous catalyst layers. The considered composite duct is relevant for a methane steam reformer and consists of a porous layer for the catalytic chemical reactions, the fuel gas flow duct and solid plate. In this paper, a fully three-dimensional calculation