Filetype
Background: Real-World evidence on mesenchymal-epithelial transition exon 14 skipping mutations (METex14) in lung cancer remains limited. With an incidence of 3–4% across histological subtypes, METex14 is now an actionable target for MET inhibitors (METi) in advanced lung cancer, demonstrating response rates between 30–70%. Yet, its role in early stages and sensitivity to immune checkpoint inhibit
Aim: Earth observation-based estimates of land–atmosphere exchange of carbon are essential for understanding the response of the terrestrial biosphere to climatic change and other anthropogenic forcing. Temperature, soil water content and gross primary production are the main drivers of ecosystem respiration (Reco), and the main aims of this study are to develop an Reco model driven by long-term g
It is still debated whether arterial elasticity provides prognostic information for cardiovascular risk beyond blood pressure measurements in a healthy population. To investigate the association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) in men and women. In 2002–2005, 2362 individuals (men=1186, 50.2%) not taking antihypert
Background Relying on freezer stored biospecimens is preferred in epidemiolocal studies exploring environmental pregnancy exposures and later offspring health. Storage duration may increase the pre-analytical variability, potentially adding measurement uncertainty. We investigated evaporation of maternal serum after long-term biobank storage using ions (sodium, Na+; chloride, Cl-) recognized for s
This study discusses issues around the integration of Syrian refugee children into the Turkish school system by using the case study of a secondary school in the city of Gaziantep in the southeast of Turkey. Based on focus groups with teachers at the school who engage with the growing number of Syrian refugee children in their classrooms, this study highlights in particular the role of Turkish lan
Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served
Within cultural and art theory, there has been an emergence of attention placed on machine vision technologies as introducing a new regime of images and ways of seeing. This paper addresses this subject in the context of environment and nature through an inquiry into machinic ways of seeing cloudscapes. Attention is placed on how the cloud form presents a challenge to the logic of machine vision t
Citizen Science (CS) projects targeting senior citizens and persons with functional impairments are rare, and interest among citizens to become involved in such remains uncertain. There is a lack of systematic analyses as to what distinguishes citizens’ willingness to contribute, and what such involvement could lead to in terms of acquired skills or changed attitudes. Based on a Swedish CS project
In this work, we present cavity ring-down transient absorption spectroscopy (CRD-TAS) as a novel technique to temporally resolve transient signals of two-dimensional samples with an increased sensitivity. The successful detection of coherent artifact signals in transparent materials is hereby demonstrated as an initial proof of concept of the singular CRD-TAS method. These experimental results are
Neurodegenerative diseases share many features, such as inflammation. Accumulating evidence support the role of neuroinflammation in the pathogenesis and treatment of neurodegenerative diseases, and inflammatory markers are suggested important tools to identify disease risk, diagnose disease, monitor disease progression or treatment response, as well as predict clinical outcomes. In Huntington’s d
