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Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. Methods: Association
The National Environmental Objectives (NEOs) adopted by Swedish Parliament in 2001 and proclaimining that major environmental problems should be solved within a generation are often portrayed as good practice of a concrete yet visionary sustainability strategy. In this paper we summarize one and a half decade of the NEOs' experience for the international audience. The NEOs were based on an eclecti
Reduction in traffic-induced ground vibrations by the use of barriers is investigated. The traffic load characteristics were measured for motorway traffic. The effects of parameters on various types of barriers were examined by the use of a finite element model that was calibrated to green-field measurements. The model involved a layered soil and bedrock. The depth of a trench and the elastic modu
The concrete discs with water-cement ratios 0.4 and 0.7 were preconditioned at their early age by drying at 50`C for 2 to 4 days, followed by storage in a Laboratory atmosphere till an age of 28 or S6 days. The moisture distributions in the specimens were determined by measuring relative humidity and capillary saturation degree, and the air permeability was determined according to the Cembureau me
‘Some textbooks treat PR as though it is a branch of moral philosophy. Such an approach leaves most PR practitioners bemused and is of limited practical use.’ (Morris & Goldsworthy 2012, 41) The grand narrative of the public relations-field in the 20th and 21st century arguably is that of professionalization. The story presented by professional associations and academics alike tells of a pract
This dissertation examines contemporary politics targeting people with intellectual disabilities. Since this group first emerged, under labels such as ‘idiocy’ and ‘mental deficiency’, around the turn of the 20th century, its members have been seen as lacking the capacities necessary for citizenship and full societal belonging. For the last forty years, however, liberal democracies and internation
Noncoding RNAs control critical cellular processes, although their contribution to disease remains largely unexplored. Dyskerin associates with hundreds of H/ACA small RNAs to generate a multitude of functionally distinct ribonucleoproteins (RNPs). The DKC1 gene, encoding dyskerin, is mutated in the multisystem disorder X-linked dyskeratosis congenita (X-DC). A central question is whether DKC1 mut
Objective To determine the relative risks of prostate cancer incidence, metastasis, and mortality associated with screening by serum prostate specific antigen (PSA) levels at age 60. Design Population based cohort study. Setting General male population of Sweden taking part in a screening trial in Gothenburg or participating in a cardiovascular study, the Malmo Preventive Project. Participants The
How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthase, DKC1, is mutated in X-linked dyskeratosis congenita (X-DC) and Hoyeraal-Hreidarsson (HH) syndrome. Here, we characterize ribosomes isolated from a yeast strain in which Cbf5p, the yeast homolog of DKC1
Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfunction and increased cancer susceptibility in the human syndrome, X-linked dyskeratosis congenita (X-DC). In a mouse model for X-DC, impairments in DKC1 function affected the translation of specific mRNAs harboring internal ribosomal entry site
Defects in ribosome biogenesis and function are present in a growing list of human syndromes associated with cancer susceptibility. One example is X-linked dyskeratosis congenita (X-DC) in which the DKC1 gene, encoding for an enzyme that modifies ribosomal RNA, is found to be mutated. How ribosome dysfunction leads to cancer remains poorly understood. A critical cellular response that counteracts
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways
The aim is to explore experiences and considerations of social workers regarding irregular migrants, understood as being prone to be “collateral damage.” It is revealed that some social workers approve assistance exceeding that which can find support in the national legislation. They are hereby addressing the normative conditions for recognition and installing new frames for apprehending irregular
The literature reveals an importance of social work in relation to all phases of crisis and disaster (Desai, 2007; IASSW 2010) and a potential to strengthen its role further (UNISDR 2015; Dominelli, 2012). Yet, little is known as regards the Swedish context. Given the centrality of municipalities in the emergency system and Social Services as a central municipal assignment it could be expected to
Traditionally, design analysts are solely responsible for all computerbased design analysis (CBDA). CBDA refers to quantitative design analyses utilising computational tools in the engineering design and development of technical solutions. There are currently limited insights into and knowledge of tools and methods needed to facilitate the use of CBDA by engineering designers. In order to gather i
