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Rights to water and water's rights: Plural water governances in mining contexts of Colombia and Peru

In large-scale mining contexts and the consequent generation of socio-environmental inequalities related to access to water, indigenous peoples and peasant communities demand the recognition of other ways of understanding water. In these contexts of dispute, emerge what we call plural water governances, which position diverse relationships and infrastructures of control of water in mining contexts

Människor slukar allt de älskar : till Pier Paolo Pasolinis pojkar och till deras mamma

En mor hämtar hem sin knappt vuxne son efter att ha varit ifrån honom nästan hela hans liv. Slutligen har hon lämnat bakom sig det mörker hon ständigt försökt skydda honom från. Hon skrattar, de dansar. on köper en motorcykel åt honom. Han stjäl saker från henne och säljer dem på den lokala marknaden. Hon sitter bakom honom när han kör genom staden. Hon lutar kinden mot hans ryggtavla och känner h

Characterization of the Mitochondrial Genetic Landscape in Abdominal Aortic Aneurysm

Background Abdominal aortic aneurysm (AAA) is a vascular disease with a mortality rate of >80% if ruptured. Mitochondrial dysfunction has been previously implicated in AAA pathogenesis. In this study, we aimed to characterize the mitochondrial genetic landscape in AAA. Methods and Results Whole mitochondrial genome sequencing and bioinformatics analysis were performed in comorbidity matched 48 cas

Inheriting “Difficult Histories” : National Identities, Memory Debates and Cultural Diversity

For some reason, modern European nations have traditionally presented themselves as having a lot of rich and important history, much of it portrayed as being “international” in terms of cultural impact and wider global significance. Today, much of this history appears to be far more controversial than many comfortable national-popular narratives have acknowledged. This article explores how Europe

Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays.

Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. Based on classical models of hematopoiesis in mouse, the self-renewal potential of HSCs is gradually and step-wise lost during the transition from long term (LT)-H

Gunnar Broberg in memoriam

Gunnar Broberg, professor emeritus i idé- och lärdomshistoria vid Lunds universitet, gick ur tiden lördagen den 30 april 2022 i en ålder av 79 år.

Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia

Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted duplex sequencing and NGS was applied on 20 infants and 7 children with KMT2A-r ALL, 5 longitudinal and 6 paired relapse samples. Of identified nonsynonym

Lung adenocarcinoma promotion by air pollutants

A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development1. Here we propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known

Biological variation of human aggrecan ARGS neoepitope in synovial fluid and serum in early-stage knee osteoarthritis and after knee injury

OBJECTIVE: To determine biological variation of the aggrecanase-generated aggrecan ARGS neoepitope in serum (sARGS) and synovial fluid (sfARGS) within and between patients with osteoarthritis (OA) or anterior cruciate ligament (ACL) injury.DESIGN: Matched samples of serum and synovial fluid were available, as parts of clinical trials, from i) 16 subjects with early-stage OA on 8 occasions over 1 y

Technical performance of a proximity extension assay inflammation biomarker panel with synovial fluid

The plasma proteome can provide a deeper understanding of the pathophysiology of different diseases and is a key source for detection of new biomarkers. Proximity extension assay (PEA), developed by Olink Proteomics (Uppsala, Sweden), detects proteins by using pairs of antibodies that are linked to oligonucleotides; upon target binding, the probes anneal when in proximity and the oligonucleotides