Precision cut lung slices (PCLS) are complex three-dimensional (3-D) lung tissue models, which preserve the native microenvironment, including cell diversity and cell-matrix interactions. They are an innovative ex vivo platform that allows studying disease as well as the effects of therapeutic agents or regulatory molecules [e.g., microRNA (miRNA)]. The aim of our study was to develop a protocol t

Proceeding from the assumptions that forgiveness is at least sometimes elective and that it changes the normative relations between victims and wrongdoers, this chapter argues that our practice of forgiveness is subject to an overlooked form of moral luck, forgiveness luck. Forgiveness luck is introduced via reflection on 'differential forgiveness', where, of two equally culpable and remorseful ag

This chapter reviews polarization vision in diverse crustaceans with a specific focus on work completed since the 2014 edition of this book. Almost all crustaceans are sensitive to the planar polarization of light. They commonly possess two channels of orthogonally arranged photoreceptors with intrinsically polarization-sensitive ordered microvilli. These two channels are compared to impart linear

Objectives: To evaluate the feasibility of AI-assisted reading of prostate magnetic resonance imaging (MRI) in Organized Prostate cancer Testing (OPT). Methods: Retrospective cohort study including 57 men with elevated prostate-specific antigen (PSA) levels ≥3 µg/L that performed bi-parametric MRI in OPT. The results of a CE-marked deep learning (DL) algorithm for prostate MRI lesion detection wer

We analyze the Boussinesq equation on the line with Schwartz initial data belonging to the physically relevant class of global solutions. In a recent paper, we determined ten main asymptotic sectors describing the large (x,t)-behavior of the solution, and for each of these sectors we provided the leading order asymptotics in the case when no solitons are present. In this paper, we give a formula v

In the northwest of Skåne, a peninsula stretches out and tapers off out into the ocean. This is Kullahalvön, a stronghold of contrasts that swings between the dramatic and romantic. Its edge rises from the sea like armor: shaped by weather and protective of all the landscape that rests behind it. Forests, meadows,fields and beaches overlap between the old fishing villages that have grown into town

On December 9, 2016, South Korea's National Assembly voted to impeach the country's president, Park Geun-hye, over abuse of power among other charges. Three months later, the Constitutional Court upheld the impeachment and she was dismissed from office-the first South Korean president to be removed this way. New elections were called. Park was then made the subject of a criminal investigation and

As an organic semiconductor and a prototypical acceptor molecule in organic photovoltaics, C60 has broad relevance to the world of organic thin film electronics. Although highly uniform C60 thin films are necessary to conduct spectroscopic analysis of the electronic structure of these C60-based materials, reported C60 films show a relatively low degree of order beyond a monolayer. Here, we develop

Context. Neutron-capture elements represent an important nucleosynthetic channel in the study of the Galactic chemical evolution of stellar populations. For stellar populations behind significant extinction, such as those in the Galactic centre and along the Galactic plane, abundance analyses based on near-infrared (NIR) spectra are necessary. Previously, spectral lines from the neutron-capture el

Many insects depend on high-altitude, migratory movements during part of their life cycle. The daily timing of these migratory movements is not random, e.g. many insect species show peak migratory flight activity at dawn, noon or dusk. These insects provide essential ecosystem services such as pollination but also contribute to crop damage. Quantifying the diel timing of their migratory flight and

Background: High-dose haemodiafiltration has been shown, in a randomised clinical trial, to result in a 23% lower risk of mortality for patients with kidney failure when compared with conventional high-flux haemodialysis. Nevertheless, whether treatment effects differ across subgroups, whether a dose–response relationship with convection volume exists, and the effects on cause-specific mortality r

This thesis explores the intersection of vernacular knowledge, modern technology and community engaging design to address the challenges posed by flooding and rising water levels in vulnerable areas. Initiated as a conceptual project for a flood resilient neighbourhood, the project evolved into a direct response to the specific needs of the DRCNAI community in Coloong, Valenzuela, Philippines. Thr

Differential growth is central to eukaryotic morphogenesis. We showed using cellular imaging, simulations, and perturbations that light-induced differential growth in a curved organ, the Arabidopsis thaliana apical hook, emerges from the longitudinal expansion of subepidermal cells, acting in parallel with a differential in the material properties of epidermal cell walls that resist expansion. The

Objectives: This study examined long-term changes in body composition and bone mineral characteristics among male long-distance runners from a high-profile university team, focusing on concerns about impaired musculoskeletal development due to extreme leanness and weight management practices in this population. Methods: Trajectory analyses were performed using multilevel modeling of 608 dual-energ

Introduction: The anatomical Lubinus SPII-stem is commonly used in hemi-arthroplasty for femoral neck fractures (FNF), combined with either the bipolar Variocup, the Unipolar Head (UH) and a newly introduced unipolar Modular Trauma Head (MTH). Similar constructs like the MTH are reported to have risk of corrosion and wear. This is the first publication evaluating the MTH. Aim: To describe the revi

Objectives. The aim was to demonstrate a reliable ex vivo method to test the function of the whole heart. Design. Pigs of varying sizes (44–80 kg) were exposed to dose response of adrenaline. Blood pressures and cardiac output were measured. The explanted hearts were tested in a novel ex vivo system to see if we could replicate the in vivo values at maximal adrenaline stimulation. The perfusion so

Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the

This paper explores perceived ethicality in entrepreneurial action. We extend the entrepreneurial action framework and propose that well-intended entrepreneurs evaluate a potential opportunity in terms of its feasibility, desirability, and ethicality. We advance a concept – ethical ambiguity – to capture situations where entrepreneurs perceive conflicting ethical interpretations based on utilitari