The finding that alkyl 1,4-dihydro-4-oxoquinoline-3-carboxylate and N-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxamide derivatives may be high-affinity ligands at the benzodiazepine binding site of the GABAA receptor, prompted a study of 3-acyl-1,4-dihydro-4-oxoquinoline (3-acyl-4-quinolones). In general, the affinity of the 3-acyl derivatives was found to be comparable with the 3-carboxylate and th

Musculoskeletal conditions often manifest with the onset of pain and the resulting physical limitations. Musculoskeletal pain is almost inevitable in in individual's lifetime. It is one of the most common reasons for self-medication and entry into the health care system. Musculoskeletal pain affects in 4 adults and is the Most commons Source of serious long-term pain and physical disability. The M

Background The study examined client factors of relevance in the establishment of helping alliance and in the prediction of dropout from a routine psychiatric setting admitting a variety of diagnoses and staffed with a multiprofessional team. Method Newly admitted patients (n=122) and staff completed questionnaires regarding helping alliance, and the patients also completed questionnaires regardin

BACKGROUND: Riks-Stroke, the Swedish national quality register on stroke care, provides unique opportunities to evaluate stroke units in routine clinical care. METHODS: Basic patient characteristics, process indicators and outcome variables are recorded in all 85 hospitals admitting acute stroke patients. A 3-month follow-up is included. RESULTS: There are wide variations between hospitals in the

What is already known about this subject * Exercise is known to affect absorption of other inhaled substances, but so far there are no reports on the effect of exercise on the absorption of inhaled insulin in humans. What this paper adds * This report is the first to investigate the effect of exercise on the absorption of inhaled insulin. * In this study in healthy volunteers we found that exercis

Time for metamorphosis and metamorph size of moor frogs Rana arvalis and common frogs R. temporaria were measured in 22 ponds for 18 years. Environmental data in these ponds were also measured. Metamorphosis of the frogs took place from the beginning of June to the beginning of August. When both species were found in one pond, the common frogs metamorphosed up to 20 days earlier than the moor frog

This is a study of the spatial and temporal variability of total hydrocarbon (THC) emissions from vegetation and soil at a subarctic mire, northern Sweden. THCs include methane (CH4) and nonmethane volatile organic compounds (NMVOCs), both of which are atmospherically important trace gases and constitute a significant proportion of the carbon exchange between biosphere and atmosphere. Reliable cha

When an animal has to meet increased demands on its working capacity, for example, for thermoregulation or parental care, two strategies are available. The animal can reallocate energy from costly maintenance processes-such as immunological defence or DNA repair systems (compensation hypothesis)-or it may try to increase the rate of energy intake or efficiency of digestion by increasing the size o

Rheumatoid arthritis (RA) affects millions of people world wide causing considerable human suffering and large socioeconomic costs. Increased knowledge of pathological pathways involved in RA will enable development of modern drugs, with reduced side effects. The mouse models offer an attractive approach to dissect the genetic and molecular mechanisms of RA.

The conventional view, as expounded by sticky-price models, is that price adjustment determines the PPP reversion rate. This study examines the mechanism by which PPP deviations are corrected. Nominal exchange rate adjustment, not price adjustment, is shown to be the key engine governing the speed of PPP convergence. Moreover, nominal exchange rates are found to converge much more slowly than pric

Recombinant activated coagulation factor VII (rFVIIa) was developed for the treatment of patients with hemophilia who have developed inhibitors against the factor they are missing. Hemophilia is a serious bleeding disorder and patients with hemophilia develop repeated spontaneous CNS, joint and muscle bleeding. Any trauma, even mild events, may cause life-threatening bleeding, and without treatmen

Little is known about the extent of the genetic diversity and its structuring patterns in protist species living in lakes. Here, we have investigated the genetic diversity patterns within five dinoflagellate species (Peridinium aciculiferum, Peridinium cinctum, Peridiniopsis borgei, Polarella glacialis, Scrippsiella aff. hangoei) that are present in lakes and sometimes, in marine habitats located

Skin resurfacing with carbon dioxide (CO2) laser is a currently popular means of improving rhytides and scars of the face. Side effects are few, but delayed healing has been reported due to infections. A case of unexplained slow healing following CO2 laser resurfacing in a previously healthy sixty-seven year old woman is reported. Although healing was extremely delayed, it is important to emphasiz

X-linked agammaglobulinemia (XLA) is a heritable immunodeficiency disorder that is caused by a differentiation block leading to almost complete absence of B lymphocytes and plasma cells. The affected protein is a cytoplasmic protein tyrosine kinase, Bruton's agammaglobulinemia tyrosine kinase (Btk). Btk along with Tec, Itk, Bmx and Txk belong to a distinct family of protein kinases. These proteins

The models and theories of occupational therapy and occupational science to a great extent lack empirical support. We need an increased understanding of the construct of occupation and its predicting factors. The objectives of this study were to explore the construct of occupation in an ageing population, and to test the construct's relationships with underlying performance components and environm