BACKGROUND: Salivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to disease risk is currently rather unknown. The aim was to investigate the association between starch intake and AMY1 copy number and risk of cardiovascular disease (CVD) and mortality and whether there is an interaction. In addition, we aim to identify CV

BackgroundMany ultraprocessed food (UPF)-derived by-products may play a role in the development of chronic kidney disease (CKD). Although several studies have assessed the association of UPFs with kidney function decline or CKD in various countries, no evidence has been shown in China and the United Kingdom.ObjectivesThis study aims to evaluate the association between UPF consumption and risk of C

The structure of a freeze-dried material is essential for its ability to preserve and protect biologics such as proteins, cells and other sensitive structures. The structure of a typical freeze-dried matrix can be described as pores surrounded by thin walls where the walls are the encapsulating material (for e.g. cells). The objective of this investigation is to evaluate X-ray microtomography (µCT

Objectives:This thesis aims to provide an overview of the epidemiology of AAV in southern Sweden, to evaluate different classification criteria in AAV. In addition we study if infection is a risk factor for later development of AAV comparing patients with AAV with a matched population cohort and to examine the occurrence of severe infections as an outcome in AAV. Methods:All adult patients diagnos

The PRDM family of methyltransferases has been implicated in cellular proliferation and differentiation and is deregulated in human diseases, most notably in cancer. PRDMs are related to the SET domain family of methyltransferases; however, from the 19 PRDMs only a few PRDMs with defined enzymatic activities are known. PRDM15 is an uncharacterized transcriptional regulator, with significant struct

Introduction: Biomarkers for the prediction of cognitive decline in patients with amnestic mild cognitive impairment (MCI) and amnestic mild dementia are needed for both clinical practice and clinical trials. Methods: We evaluated the ability of tau-PET (positron emission tomography), cortical atrophy on magnetic resonance imaging (MRI), baseline cognition, apolipoprotein E gene (APOE) status, pla

Introduction: Research comparing levodopa/carbidopa intestinal gel (LCIG), deep brain stimulation (DBS), and continuous subcutaneous apomorphine infusion (CSAI) for advanced Parkinson’s disease (PD) is lacking. This network meta-analysis (NMA) assessed the comparative effectiveness of LCIG, DBS, CSAI and best medical therapy (BMT) in reducing off-time and improving quality of life (QoL) in patient

This study aimed to examine what it means for counsellors in end-of-life care to work closely with death and the dying. The initial hypothesis was that there is something special about being in close contact with dying people and death. A qualitative approach was taken with an initial focus group of four professionals to study this. The goal of the focus group was to acquire knowledge on how this

This chapter presents the results of a production study with twelve speakers of South Swedish. The results show that South Swedish has so-called two-peak contours in non-utterance-final nuclear accents and in phrase-initial accents (so-called initiality accents). The shape of the two-peak contours is reminiscent of contours reported from East Norway and West Sweden. These results contradict previo

Introduction: We investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess th

Både på upphovsrättens område och på formgivningsrättens område inskränks rättighetsinnehavarnas ensamrätt av regler som gör det möjligt citera ur skyddade alster. Den upphovsrättsliga citatregeln stadgas i 22 § upphovsrättslagen (1960:729). Den formgivningsrättsliga citatregeln återfinns i 7 § 3 mönsterskyddslagen (1970:485) och i artikel 20.1 c i formgivningsförordningen. I uppsatsen görs en rBoth copyright law and design law provide rules that limit the exclusive rights of the rightsholders in order to allow users to quote protected works and other protected subject matter. Such rules are prescribed in section 22 of the Swedish Copyright Act (SFS 1960:729), section 7 paragraph 3 of the Swedish Design Protection Act (SFS 1970:485) and article 20.1 c of the EU Design Regulation. The ai

For the past years, the national rhetoric in Sweden has changed. Due to the Russian actions in Ukraine and Crimea, efforts towards mobilizing military and civil preparedness increased. The concept of the ‘total defence’ was reintroduced and has led to shifting priorities in Swedish politics, serving as a happy object and remedy in times of security threat and social anxiety. The article critically

Arbetsgivarens rehabiliteringsansvar innebär, i samband med att en arbetstagare får nedsatt arbetsförmåga till följd av sjukdom, en skyldighet att utreda arbetsanpassnings- och rehabiliteringsmöjligheterna för att möjliggöra återgång i arbete. Rehabiliteringsansvaret regleras främst inom lagen om (1982:80) anställningsskydd, arbetsmiljölagen (1977:1160), socialförsäkringsbalken (2010:110) och kompThe employer's responsibility to rehabilitate is, in connection with an employee's reduced ability to work as a result of illness, an obligation to investigate work adaptation and rehabilitation possibilities to enable a return to work. The responsibility for rehabilitation is mainly regulated within the Employment Protection Act (LAS), the work environment act (AML), the social insurance

Den svenska entreprenadsektorn innehar en särställning inom obligationsrätten på så sätt att det saknas lagstiftning och att det ofta rör sig om komplexa avtalssituationer där den befintliga lagstiftningen inte är direkt tillämpbar. Entreprenaderna är ofta långa avtalsförhållanden som involverar flertalet parter och entreprenörer i flera led, samtidigt som hela entreprenaden i vissa fall kan vara The Swedish construction sector holds a special position in the law of obligations because there is no legislation and there are often complex contractual situations where the existing legislation is not directly applicable. The contracts are often long-term contractual relationships that involve several parties and contractors in several stages, while the entire contract in some cases is fully de

Den utbredda gängkriminaliteten har på senare tid blivit ett alltmer angeläget ämne i den politiska debatten i Sverige och antalet ökade dödsskjutningar i kriminella miljöer har föranlett starka reaktioner. Denna brottsutveckling har motiverat lagstiftaren till att vidta åtgärder i form av utökad lagstiftning som syftar till att möjliggöra effektivare verktyg inom den brottsbekämpande verksamhetenWidespread gang-related crimes have become an increasingly important topic of political debate in Sweden and the escalated number of shootings in criminal environments have caused strong reactions. This has motivated the legislator to extend legislation in a way that enables more effective tools within the law enforcement. A suggestion that has been presented by an investigator for such a measure

Det har länge varit känt att delar av läkares yrkesutövning är av sådan karaktär att den i objektiv mening uppfyller rekvisiten i vissa brottsbestämmelser. Eftersom sjukvården är en önskvärd verksamhet från samhällets sida finns det ett behov av en straffrättslig ansvarsfrihetsregel eller princip som motiverar tillåtligheten i läkares yrkesutövning. I denna uppsats undersöks läkares befogenheter oIt has long been recognized that the professional practice of doctors is of such a nature that in an objective sense it fulfills the requirements of certain criminal acts. Since healthcare is a desirable activity on the part of society, the professional practice of doctors needs to be covered by a discharge from liability that justifies the permissibility of medical practice. This paper examines t

BACKGROUND: There is rapid growth of older people in Low- and Middle- Income Countries (LMICs). The aim of this review was to assess the literature on prevalence of anxiety and depression in this demographic, which to our knowledge, has not yet been conducted.METHODS: Databases including Medline, PsychInfo, Embase, Scielo and African Journals Online were searched for terms including "mental disord