Swedish asthma guidelines recommend treating asthma with the lowest effective dose possible. These recommendations are both hard to follow and seldom considered enough in asthma care today. As an example, combination therapy with inhaled corticosteroids (ICS) and long acting beta agonists (LABA) should only be considered if asthma control is not achieved with low to medium dose ICS daily. However,

Business model innovation is an important lever for change to tackle pressing sustainability issues. In this paper, 'sufficiency' is proposed as a driver of business model innovation for sustainability. Sufficiency-driven business models seek to moderate overall resource consumption by curbing demand through education and consumer engagement, making products that last longer and avoiding built-in

Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we performed ribonucleic acid sequencing of flow-sorted primitive (CD34+CD38low) and

Are we using the right potential functions in the Conditional Random Field models that are popular in the Vision community? Semantic segmentation and other pixel-level labelling tasks have made significant progress recently due to the deep learning paradigm. However, most state-of-the-art structured prediction methods also include a random field model with a hand-crafted Gaussian potential to mode

Let R denote a connected region inside a simple polygon, P. By building barriers (typically straight-line segments) in P∖R, we want to separate from R part(s) of P of maximum area. All edges of the boundary of P are assumed to be already constructed or natural barriers. In this paper we introduce two versions of this problem. In the budget fence version the region R is static, and there is an uppe

Current evidence on congenital malformations in the offspring of cancer survivors is largely inconsistent. Therefore, through this study we aimed to explore the prevalence of congenital malformations in the offspring of cancer survivors. To this end, female cancer survivors were identified from the Swedish Cancer Register and were further linked to the Swedish Medical Birth Register and Hospital D

A detailed fire investigation of most fires occurring in the greater London area has been underway since 1994. The present study concerns 307 fires in non-residential buildings there between 1994 and 1997. The cause of the fire, the means of discovery, the times to detection, to arrival of the fire brigade and to extinguishing the fire, the size of fire and the process of extinguishing it are inve

the research investigates how students perceive new approaches within language teaching. The background to the project is that students enrolled in the MA program in Middle Eastern Studies had to learn Arabic quickly, to be able to do field work and operate within Arabic speaking contexts. But beyond exploring new ways for students to pick up Arabic at a fast pace, Barhoum and Avery believe that t

This article provides an analysis on how disruptive innovation is spurred by the dynamics of digital and analogue networks in the sharing economy. The analysis builds on a free guided tour company in Copenhagen. Data is collected in a bottom-up reiterative process, drawing on theories on disruptive innovation and network theory. Between 2013 and 2016, one of the free tour companies in Copenhagen w

A search for electroweak production of supersymmetric particles in scenarios with compressed mass spectra in final states with two low-momentum leptons and missing transverse momentum is presented. This search uses proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015-2016, corresponding to 36.1 fb-1 of integrated luminosity at s=13 TeV. Events with same-

We provide an approximate analytical solution for the substrate-microbial dynamics of the organic carbon cycle in natural soils under hydro-climatic variable forcing conditions. The model involves mass balance in two carbon pools: substrate and biomass. The analytical solution is based on a perturbative solution of concentrations, and can properly reproduce the numerical solutions for the full non

At the southern margin of permafrost in North America, climate change causes widespread permafrost thaw. In boreal lowlands, thawing forested permafrost peat plateaus (‘forest’) lead to expansion of permafrost‐free wetlands (‘wetland’). Expanding wetland area with saturated and warmer organic soils is expected to increase landscape methane (CH4) emissions. Here, we quantify the thaw‐induced increa

Objective: To explore the involvement of the wingless-type MMTV integration site (WNT) and bone morphogenetic protein (BMP) antagonists dickkopf-related protein 1 (DKK1), frizzled-related protein (FRZB) and gremlin 1 (GREM1) in knee injury and osteoarthritis (OA). Design: The antagonists were immunoassayed in synovial fluid from a cross-sectional cohort of nine knee healthy reference subjects, pat

REVIEW QUESTION/OBJECTIVE: The objectives of this review are to explore parents' experiences of communication with healthcare professionals and to identify the meaningfulness of communication to parents in the neonatal intensive care unit (NICU).More specifically, the objectives are to identify.

BACKGROUND: Blood group phenotype variation has been attributed to potential resistance to pathogen invasion. Variation was mapped in blood donors from Lampang (northern region) and Saraburi (central region), Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized and the data were correlated with phenotypes. The high incidence of the Vel-negative

Denna doktorsavhandling undersöker samtal om personliga problem i mötet med en specialist i radio. I synnerhet handlar studien om den dynamiska process då förståelse skapas – när upplevelser av personliga bekymmer förklaras och definieras som problem av särskilda slag. Denna meningsskapande process undersöks i detalj så som den utspelar sig i dialoger i radio och mellan programdeltagare och radiolThe dissertation examines how personal troubles are talked about in an encounter with a professional on the public arena of radio broadcasting, where the professional has to meet the challenge of making professional advice not only useful for the person seeking help, but also relevant or interesting for the radio audience. The study explores the dynamic process of shaping an understanding of probl