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The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic tyrosine kinases, contains Src homology domains (SH2 and SH3), and catalytic kinase domain. SH3 domains are important for the targeting of signal

For the period 1420-1960 we contrasted fire events reconstructed at 14 sites distributed over a 50 km x 50 km area in the central part of the Komi Republic (European Russia) with a set of tree-ring width chronologies of Scots pine (Pinus sylvestris L.), developed for the same area. Our aim was to infer common climatic information contained in treering variables and independently dated fire events

Actin- and myosin-like immunoreactivity is found in cells located in the theca externa of the follicle wall of the human ovary, and corresponding to previously observed myoid cells. The immunocytochemical observation provides direct structural evidence that non-vascular contractile cells are also present in the follicle wall in humans. As expected, perifollicular blood vessels showed a positive im

Background: The variation in retinal nerve fibre layer thickness (RNFLT) as measured by Stratus optical coherence tomography (OCT) in healthy subjects may be reduced when the effect on RNFLT measurements of factors other than disease is corrected for, and this may improve the diagnostic accuracy in glaucoma. With this perspective we evaluated the isolated and combined effects of factors potentiall

The sodium (Na+)/iodide (I-)-symporter (NIS) is abundantly expressed and accumulates iodide in thyroid follicular cells. The NIS is also found in extrathyroidal tissues, particularly gastric mucosa. Controversies exist on the localization of extrathyroidal NIS. We have studied the presence of both NIS peptide and NIS messenger RNA (mRNA) in the digestive tract and thyroid from different mammals. T

This study investigated behaviour of male European pine sawflies, Neodiprion sertifer Geoffr. (Hym., Diprionidae), that were released downwind from pheromone traps. Releases were done at three distances; either at 5 m from one trap, or at 50 m or 200 m from five traps, placed in a line perpendicular to the current wind direction. As a control, males were released identically but without any pherom

Gases leaking from a polyethene plant and a cracker plant were visualized with the gas-correlation imaging technique. Ethene escaping from flares due to incomplete or erratic combustion was monitored. A leakage at a high-pressure reactor tank could be found and visualized by scanning the camera system over the industrial site. The image processing methods rely on the information from three simulta

It has been shown that the generally accepted assumption that hydrophobic molecules and ions repel each other in polar solvents is only valid for moderately polar solvents. When the dipole moment of the medium molecules is increased, then ions and hydrophobic particles start to attract each other. For particles with the size and dipole moment of a water molecule one can expect that the effective p

OPENLAND3 belongs to a suite of computer programs included in the POLLSCAPE simulation model. These programs make it possible to calculate estimates of pollen loadings in lake basins or bogs using vegetation data. OPENLAND3, written in Visual Basic 6, is designed to produce appropriate vegetation data files from vegetation maps stored in a Geographical Information System. It calculates percentage

In this report we consider the linear quadratic control problem under the restriction that the control variable is constant over the sampling intervals. Algorithms and flow chart for numerical solution are presented. The program can be used to design optimal control systems and to compute optimal filters and predictors for implementation on process control computers.

Wilms tumor (WT) is characterized by a nonrandom pattern of chromosome aberrations, but the clinical significance of different cytogenetic patterns is unknown. The present study describes the cytogenetic findings and the clinical course in a cohort of 39 children with WT. Samples for short-term culturing and cytogenetic analysis were obtained during a 15-year period. Clonal chromosome aberrations