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BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a critical role in neuronal development and neural connectivity, and has been implicated in the pathophysiology of Major Depressive Disorder (MDD). However, its predictive value for MDD onset remains unclear. This study examined whether baseline BDNF levels are associated with incident MDD in middle-aged women.MATERIAL AND METHODS: In this

Smart city control rooms are prominent components of the smart city discourse. They embody a long-­ standing dream to visualize and manage multiple urban processes in real time through the collation of data flows. Previous research has produced important insights into the design, construction and operation of these facilities. However, this research has largely overlooked the fundamental changes t

BackgroundThe purpose was to evaluate the prognostic impact of aryl hydrocarbon receptor (AHR) genotypes in relation to lifestyle and adjuvant treatments in breast cancer.MethodsAHR genotyping was performed on genomic DNA from 1701 patients included 2002–2016 in Lund, Sweden, and followed for up to 15 years. Eight AHR polymorphisms and eight haplotypes were analysed using survival and interaction

Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B (MTNR1B) is robustly associated with increased risk of T2D. This single-nucleotide polymorphism (SNP; rs10830963; G-allele) is an expression quantitative trait locus (eQTL) in human pancreatic islets, conferri

Background: Prolactin receptor (PRLR) signaling affects breastfeeding and potentially breast cancer treatment response. Methods: The prognostic impact of 20 PRLR single nucleotide polymorphisms (SNPs) in relation to adjuvant treatment groups in patients with primary breast cancer (n = 1701, 2002–2016, Sweden) was evaluated. Genomic DNA was genotyped on Illumina OncoArray, and survival analyses wit

The effects of high hydrostatic pressure (up to 8 kbar) on bacteriochlorophyll a Qy electronic absorption bands of LH2 photosynthetic antenna complexes have been studied at ambient temperature. A variety of samples were studied, including intact membranes and isolated complexes from wild type and mutant photosynthetic bacteria Rhodobacter sphaeroides, Rhodopseudomonas acidophila, and Rhodospirillu

A central function of human cognition is the ability to perceive, understand, and remember life experiences as meaningful sequences of discrete events. This process, known as event segmentation, allows individuals to spontaneously construct and update event models and has been shown to engage a distributed network of brain regions that transiently increase in activity at event boundaries (e.g., Za

We review concepts and recent work related to creating light-matter interfaces for future quantum networks based on rare-earth ion-doped crystals. More precisely, we explore their unique suitability for creating photon sources, optical quantum memories for light, and qubits that allow quantum information processing. In addition, we review the state-of-the-art of elementary quantum repeater links,

We develop a framework for categorization in games, applicable both to multistagegames of complete information and static games of incomplete information.Players use categories to form coarse beliefs about their opponents’behavior. Players best-respond given these beliefs, as in analogy-based expectationsequilibria. Categories are related to strategies via the requirementsthat categories contain a

Objective: To overview and summarise the Swedish National Guidelines on Urothelial Carcinoma 2024. Methods: A narrative review of the updated guidelines was performed, highlighting new treatment recommendations for advanced and metastasized disease. Results: Compared to the previous guideline version, the current update includes recommendations for standardised radiological reporting when urotheli

Spectral imaging allows for the simultaneous visualization of multiple different spectral bands of a scene, and is a powerful tool used in a range of contexts - from the color cameras in smart phones, to scientific imaging applications such as remote sensing and fluorescence microscopy. The progress within these fields of research is therefore intrinsically linked to the advances made for more eff

Stem cells are key to human tissue maintenance. Because tissue maintenance allows us to live and reproduce, stem cell control is fundamental for animal life and evolution. A team of researchers set out to explore the origins of transcription factors at the core of the induction and the maintenance of stemnss. They focus on the conservation of the Sry-related box 2 (Sox2) and the octamer-binding tr

Identifying patients at high risk of bone fracture is an important task. The clinical risk assessment, based on measurements of bone mass, correlates with strength but not toughness and is insufficient for reliable identification of high-risk patients. Starting from non-linear fracture mechanics, we hypothesise that reduced bone tissue fracture toughness and characteristic length, possibly in comb

Managed honey bees (Apis mellifera L.) are increasingly used worldwide to meet the growing demand for agricultural pollination services and honey production. The spillover of managed honey bees into natural habitats can strongly transform wild plant-pollinator communities, resulting in mixed consequences for plant reproduction. To effectively predict and cope with the impacts of managed honey bees

Gyalolechia fruticum, a new epiphytic species with a Mediterranean-Macaronesian distribution, is described. It differs in molecular data and in ecology from two closely related calcicolous species, G. luteococcinea and G. marmorata, both formerly called Caloplaca subochracea auct. The new species grows on coastal shrubs (rarely on wood), accompanied by species-rich communities of maritime epiphyti

We report a parametric simulation study of traveling calcium waves in two classes of cellular structures: dendrite-like processes and an idealized cell body. It is motivated by the hypothesis that calcium waves may participate in spatiotemporal sensory processing; accordingly, its objective is to elucidate the dependence of traveling wave characteristics (e.g., propagation speed and amplitude) on

Using population reconstructions from linked civil certificates for the province of Zeeland, the Netherlands, for the period 1812–1913, I study the social gradient in maternal mortality. Maternal mortality is defined as deaths in the first 42 days after the birth of a child. Among the women — mother to at least one child and followed between age 20 and 45 — maternal mortality constitutes about one

In this article, we study a susceptible–infected–recovered (SIR) epidemic model on a network of n interacting subpopulations. We analyze the transient and asymptotic behavior of the infection dynamics in each node of the network. In contrast to the classical scalar epidemic SIR model, where the infection curve is known to be unimodal (either always decreasing over time, or initially increasing unt