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Personalized Approach to Severe Asthma
Two Orders of Magnitude Variation in the Star Formation Efficiency across the Premerger Galaxy NGC 2276
We present the first spatially resolved (∼0.5 kpc) measurements of the molecular gas depletion time τ depl across the disk of the interacting spiral galaxy NGC 2276, a system with an asymmetric morphology in various star formation rate (SFR) tracers. To estimate τ depl, we use new NOEMA observations of the 12CO(1-0) emission tracing the bulk molecular gas reservoir in NGC 2276, and extinction-corr
A realized vision of access to safe, affordable surgical and anaesthesia care
Scrutinizing the cut-off for “pathological” meniscal body extrusion on knee MRI
Objectives: Medial meniscal body extrusion ≥ 3 mm on MRI is often considered “pathologic.” The aims of this study were to (1) assess the adequacy of 3 mm as cut-off for “pathological” extrusion and (2) find an optimal cut-off for meniscal extrusion cross-sectionally associated with radiographic knee osteoarthritis, bone marrow lesions (BMLs), and cartilage damage. Methods: Nine hundred fifty-eight
An update on the GLOB blood group system (and former GLOB collection)
CONCLUSIONS: The main change that has occurred in the GLOB blood group system since the GLOB review published in this journal in 2013 is the addition of an antigen. The high-prevalence PX2 antigen, originally recognized as the x2 glycosphingolipid, is expressed on red blood cells of most individuals and is elevated in the rare PP1Pk-negative p blood group phenotype. P synthase, encoded by B3GALNT1
Perturbations in the carbon cycle during the carnian humid episode : Carbonate carbon isotope records from southwestern China and Northern Oman
The Carnian Humid Episode is an interval of prominent climatic changes in the Late Triassic. We studied the carbon isotope (δ13C) geochemistry of carbonates from sections in southwestern China and northern Oman. δ13C records from the Yongyue section (western Guizhou, South China) show a progressive positive shift from 1.4 to 2.8‰ in the early to middle Julian 1 substage. This positive trend is fol
Trade-off Between Antenna Efficiency and Q-Factor
The trade-off between radiation efficiency and antenna bandwidth, expressed in terms of Q-factor, for small antennas is formulated as a multi-objective optimization problem in current distributions of predefined support. Variants on the problem are constructed to demonstrate the consequences of requiring a self-resonant current as opposed to one tuned by an external reactance. The trade-offs are e
The ARC Information System: overview of a GLUE2 compliant production system
Beskrivning av NorduGRID ARC middleware information system
Dialog eller dynamit : Viktor Rydberg och August Strindberg – förtryckets fiender
Trots att Viktor Rydberg och August Strindberg tillhörde olika generationer var de verksamma samtidigt under drygt 25 års tid. För första gången får vi här en grundlig inblick i deras åsikter om varandra samt en uppfattning om de impulser de fått från varandras författarskap. Studien bygger på brevmaterial och ingående textanalyser. Under 1880-talet när motståndet mot konservatismen polariserades,
Further evidence for an impact origin of the Tsenkher structure in the Gobi-Altai, Mongolia : Geology of a 3.7 km crater with a well-preserved ejecta blanket
The Tsenkher structure in the Gobi-Altai, Mongolia is a c. 3.7 km diameter crater with a well-preserved ejecta blanket. It has been hypothesized to be either of impact or volcanic origin in our previous work. Observations during our 2007 expedition and related sample analyses give further support for an impact origin. The evidence includes the presence of a structurally uplifted near-circular rim
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion
HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed for ErbB2-induced invasion are poorly understood. Here, we link ErbB2 activation to invasion via ErbB2-induced, SUMO-directed phosphorylation of a single serine residue, S27, of the transcription factor myeloid zinc finger-1 (MZF1). Utilizing
Application of the isotope pairing technique in sediments : Use, challenges, and new directions
Determining accurate rates of benthic nitrogen (N) removal and retention pathways from diverse environments is critical to our understanding of process distribution and constructing reliable N budgets and models. The whole-core 15N isotope pairing technique (IPT) is one of the most widely used methods to determine rates of benthic nitrate-reducing processes and has provided valuable information on
Anonymous Writings and Anonymous Accusation in Imperial Chinese Law
Introduction: Uses of the Past: Sharīʿa and Gender in Legal Theory and Practice in Palestine and Israel
Policy design for the Anthropocene
Today, more than ever, ‘Spaceship Earth’ is an apt metaphor as we chart the boundaries for a safe planet1. Social scientists both analyse why society courts disaster by approaching or even overstepping these boundaries and try to design suitable policies to avoid these perils. Because the threats of transgressing planetary boundaries are global, long-run, uncertain and interconnected, they must be
"Color, Materiality, Sensory Experience and Late Bronze Age Burials in the Argolid"
One aspect of tombs and burials in the BA Aegean in general that has not received much notice is that of color (hue and shine). Were certain hues more predominant than others? Was this significant? Was the presence (or absence) of shine of importance? Following a discussion of ‘what is color?’, the study and results of the colors of the finds from Late Bronze Age tombs at three sites in the Greek
Linear Quadratic Control under Quadratic Constraints
The linear quadratic optimal control problem under quadratic constraints is an optimization problem over a generally non-convex set. Yakubovich [8] and Megretski [4] have studied this problem, and they show how it may be translated into a two-stage, convex optimization problem. In this paper we study the linear quadratic control problem under quadratic constraints for generalized first-order syste
Health-Related Quality of Life in Children and Young Adults with Marfan Syndrome
OBJECTIVE: To assess health-related quality of life (HRQOL) in a large multicenter cohort of children and young adults with Marfan syndrome participating in the Pediatric Heart Network Marfan Trial.STUDY DESIGN: The Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales were administered to 321 subjects with Marfan syndrome (5-25 years). PedsQL scores were compared with healthy popul
Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome
Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and referral for aortic surgery, we investigated the data from the Pediatric Heart Network randomized trial of atenolol versus losartan in young patients with MFS. Data were analyzed from the echocar