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Fast visual adaptation to dim light in a cavity-nesting bird

Many birds move fast into dark nest cavities forcing the visual system to adapt to low light intensities. Their visual system takes between 15 and 60 min for complete dark adaptation, but little is known about the visual performance of birds during the first seconds in low light intensities. In a forced two-choice behavioural experiment we studied how well budgerigars can discriminate stimuli of d

Analysis of visual and acoustic measures for self-evacuations in road tunnels using virtual reality

Emergency fire situations in tunnels can be especially dangerous when occurring in long underground or subsea tunnels, particularly when evacuation on foot is the only alternative. This paper presents the results from a study comparing different visual and acoustic measures to facilitate efficient and safe emergency evacuation and their effect on people's self-rescue behaviour in response to a tun

Tick chemosensation and implications for novel control strategies

Ticks pose a major threat to the health of humans and animals. The use of synthetic acaricides and repellents has raised the concerns of potential health and environmental risks and increasing resistance in ticks. This article highlights the importance of the research on tick chemosensation in developing novel control agents. It provides a review on our current understanding of tick chemosensory s

Collagen VI : Role in synaptic transmission and seizure-related excitability

Collagen VI (Col-VI) is an extracellular matrix protein primarily known for its bridging role in connective tissues that has been suggested to play a neuroprotective role. In the present study we report increased mRNA and protein expression of Col-VI in the hippocampus and cortex at a late stage of epileptogenesis in a post-status epilepticus (SE) model of epilepsy and in brain tissue from patient

Regenerative business strategies : A database and typology to inspire business experimentation towards sustainability

In a time marked by growing environmental and societal challenges, where multiple planetary boundaries are being crossed, the way we conduct business practices needs to be rethought. Regenerative business models offer a path towards a more responsible future by incorporating strategies that go beyond net zero and focus on actively restoring the natural and social systems they operate in, creating

Expanding the therapeutic potential of neuro(active)steroids : a promising strategy for hyperdopaminergic behavioral phenotypes

Imbalances in dopamine activity significantly contribute to the pathophysiology of several neuropsychiatric disorders, including addiction, ADHD, schizophrenia, impulse control disorders, and Parkinson's Disease. Neuro(active)steroids, comprising endogenous steroids that finely modulate neuronal activity, are considered crucial regulators of brain function and behavior, with implications in variou

New theory to explain the effect of lactose fines on the performance of adhesive mixtures for inhalation

A new theory for the dispersibility enhancing effect of excipient fines for adhesive mixtures for inhalation is presented in this paper, while at the same time the shortcomings of current hypotheses are discussed. The proposed mechanism, denoted the ‘viscoelastic damping effect’, states that the presence of fines particles acts to dampen the collisions between carrier particles during mixing. As a

Multi-dimensional hadron structure through the lens of gluon Wigner distribution

In this review, we present the current status of phenomenological research on constraining the multi-dimensional proton (and nucleus) structure at high energies through studies of the so-called gluon Wigner distributions. We provide a brief pedagogical introduction into the corresponding theoretical definitions and modelling of exclusive and diffractive scattering observables in terms of the Wigne

Short photoperiods end autumn migration in a naïve diurnal migrant

Many migratory animals use daylength, or photoperiod, to signal when to migrate and transition between annual phenological states. Whether animals use photoperiod as a temporal or spatial cue while migrating, however, requires additional empirical support. We used hatch-year dunnocks, Prunella modularis (a songbird), caught during their first migration in southern Sweden to elucidate whether migra

Maculopathy and adult-onset ataxia in patients with biallelic MFSD8 variants

Background: Biallelic variants in the major facilitator superfamily domain containing 8 gene (MFSD8) are associated with distinct clinical presentations that range from typical late-infantile neuronal ceroid lipofuscinosis type 7 (CLN7 disease) to isolated adult-onset retinal dystrophy. Classic late-infantile CLN7 disease is a severe, rare neurological disorder with an age of onset typically betwe

Image analysis of acoustic data and interpretation of rock stress orientations for geothermal exploration in Gothenburg borehole GE-1, SW Sweden

This study contributes to geothermal exploration in 1660–1520 Ma old, reworked bedrock in Sweden. Our primary objectives are to constrain the orientation of horizontal stresses, and to discuss implications for geothermal exploration. High-resolution acoustic televiewer image data reveal the downhole distribution of stress indicators (borehole breakouts, drilling-induced fractures and petal centrel

In-Flight Tuning of Au-Sn Nanoparticle Properties

Multimetallic nanoparticles possess a variety of beneficial properties with potential relevance for various applications. These metallic nanoparticles can consist of randomly ordered alloys, which retain the properties of the constituting elements, or ordered intermetallics, which possess extended properties. Depending on the desired application, specific alloys or intermetallic compounds are requ

Topological superconductivity in a magnetic-texture coupled Josephson junction

Topological superconductors are appealing building blocks for robust and reliable quantum information processing. Most platforms for engineering topological superconductivity rely on a combination of superconductors, materials with intrinsic strong spin-orbit coupling, and external magnetic fields, detrimental for superconductivity. We propose a setup where a conventional Josephson junction is lin

Thrombin-derived C-terminal peptides bind and form aggregates with sulfated glycosaminoglycans

Glycosaminoglycans (GAGs) such as heparin and heparan sulfate (HS) play crucial roles in inflammation and wound healing, serving as regulators of growth factors and pro-inflammatory mediators. In this study, we investigated the influence of heparin/HS on thrombin proteolysis and its interaction with the generated 11 kDa thrombin-derived C-terminal peptides (TCPs). Employing various biochemical and

The tangled warp of the Milky Way

Aims. We aim to determine the influence of the Milky Way's warp on the kinematics of stars across the disc, and therefore measure its precession rate and line of nodes under different assumptions. Methods. We applied Jeans'first equation to a model of a rigidly precessing warp. The predictions of these models were fitted to the average vertical velocities of stars with measured line-of-sight veloc

Towards a data-driven model of hadronization using normalizing flows

We introduce a model of hadronization based on invertible neural networks that faithfully reproduces a simplified version of the Lund string model for meson hadronization. Additionally, we introduce a new training method for normalizing flows, termed MAGIC, that improves the agreement between simulated and experimental distributions of high-level (macroscopic) observables by adjusting single-emiss

Exploring the viability of a pseudo-Nambu-Goldstone boson as ultralight dark matter in a mass range relevant for strong gravity applications

We study a simple extension of the Standard Model featuring a dark sector with an ultralight pseudo-Nambu-Goldstone boson as a dark matter candidate. We focus on the mass range O(10-20-10-10) eV, relevant for strong gravity applications, and explore its production and evolution in the early Universe. The model is formulated in such a way that dark matter does not couple directly to photons or othe

Elemental and Structural Characterization of Heterotopic Ossification during Achilles Tendon Healing Provides New Insights on the Formation Process

Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at

Rare manifestations and malignancies in tuberous sclerosis complex : findings from the TuberOus SClerosis registry to increAse disease awareness (TOSCA)

BACKGROUND: Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant disorder caused by pathogenic variants in either the TSC1 or TSC2 gene. Common manifestations of TSC have been grouped into major and minor clinical diagnostic criteria and assessed in clinical routine workup. However, case studies point towards the existence of rare disease manifestations and to the potential as